Provided herein are antibacterial compositions and methods of making and using the compositions.

The invention provides isolated, purified, recombinant receptor binding proteins Gp-6, Gp-10 and Gp-31 from mycobacterium phage L5, and methods for producing these recombinant receptor binding proteins. The invention also provides the use of recombinant receptor binding proteins, including Gp-6, Gp-10 and Gp-31, as probes for the identification and diagnosis of mycobacterium infections and conditions caused by mycobacterium. Further provided by the invention are methods of targeting mycobacteria using recombinant receptor binding proteins, including Gp-6, Gp-10 and Gp-31. Other methods provided by the invention include the use of recombinant receptor binding proteins, such as Gp-10, in diagnostic assays for diseases, such as Johne's disease, in animals, including ruminants.

A vector production system is provided. The system comprises recombinant cells designed to encode at least a first recombinase under the control of an inducible promoter and the cells include an expression vector encoding a nucleic acid of interest within the regulatory elements of the expression vector which are flanked on either side by a target sequence for at least the first recombinase. The vector production system provides an efficient one-step process for producing linear or circular covalently closed vectors that incorporate a nucleic acid sequence of interest.

The present invention relates to a method for screening for changes in the infectivity range of one or more bacteriophages due to epigenetic imprinting of the bacteriophage(s) as well as a method for screening for one or more bacteriophages with a specific infectivity range due to the epigenetic imprinting of the bacteriophages. The invention furthermore relates to compositions comprising bacteriophages identified and obtained or obtainable by these methods and their use in therapy as well as for the selective killing of bacteria.

Provided herein are antibacterial compositions and methods of making and using the compositions.

The present invention relates to novel bacteriophages specific to Klebsiella pneumoniae strains, and compositions comprising the same. Particularly, polypeptides and their coding nucleic acid molecule of the novel bacteriophages are provided. The invention also relates to applications of the novel bacteriophages and the polypeptides in the detection/treatment/prevention of infection caused by Klebsiella pneumoniae strains. Development of immunogen and vaccine on the basis of the polypeptides are also provided.

The invention relates to a method of preventing or treating pathogenic bacterial infectious diseases by providing a pharmaceutical composition comprising a LysSAP26 protein, wherein the LysSAP26 protein is a recombinant protein composed of an amino acid sequence derived from the bacteriophage genome and has the amino acid sequence set forth in SEQ ID NO: 1 as an active ingredient, and administering the pharmaceutical composition to a subject.

The present invention relates to novel bacteriophages specific to Klebsiella pneumoniae strains, and compositions comprising the same. Particularly, polypeptides and their coding nucleic acid molecule of the novel bacteriophages are provided. The invention also relates to applications of the novel bacteriophages and the polypeptides in the detection/treatment/prevention of infection caused by Klebsiella pneumoniae strains. Development of immunogen and vaccine on the basis of the polypeptides are also provided.

Provided herein are antibacterial compositions and methods of making and using the compositions.

The present invention relates to recombinant targeting peptides, compositions comprising said targeting peptides and methods of targeted delivery of therapeutics suitable for the control, improvement and/or treatment of acne. More particularly, the present invention provides engineered targeting peptides that bind specifically to the cell wall of Cutibacterium acnes, capable of providing a homing mechanism for transporting nanoparticles comprising therapeutics to C. acnes. Accordingly, the present invention also provides methods and compositions comprising the recombinant targeting peptides for localized delivery of therapeutics to C. acnes.