A method for treating hypertrophic cardiomyopathy (HCM) utilizes an RF ablation electrode needle system that has an RF ablation generator, and an electrode needle. The distal end of the electrode needle is introduced to puncture within myocardium after piercing through epicardium and then advanced along an intramyocardial pathway between endocardia at two lateral sides of the interventricular septum to reach a hypertrophic area of an interventricular septum. The RF ablation generator is then turned on to implement single-point or multi-point ablation on the hypertrophic area of the interventricular septum, and then the RF electrode needle is withdrawn from the patient.

Embolic material capture catheters and related devices and methods constrain a distal end portion of an embolic material capture element in an insertion configuration. A method of deploying an embolic material capture element in a blood vessel includes constraining a distal end portion of the embolic material capture element in an insertion configuration via engagement with a dilator assembly. The embolic material capture element, in the insertion configuration, is advanced through the blood vessel. A deployment cap of the dilator assembly is distally advanced relative to a dilator sheath of the dilator assembly to release the distal end portion of the embolic material capture element from engagement with the dilator assembly to reconfigure the embolic material capture element from the insertion configuration to a fully deployed configuration via self-expansion of the embolic material capture element.

A method of removing embolic material from a vessel with mechanical and aspiration assistance. The method comprises the steps of providing an aspiration catheter having a central lumen and a distal end, advancing the distal end of the aspiration catheter to obstructive material in a vessel, applying vacuum to the central lumen to draw clot into the central lumen, introducing a thrombus engagement tool into the central lumen, and manually manipulating the tip to engage clot between the tip and an inside wall of the central lumen.

An intravascular filter for blocking passage of embolic debris into the cerebral and aortic circulation upon removal of the cross clamp from the aorta during open heart surgery. The filter comprises a self expandable tubular wire frame, having a proximal end, a distal end and a lumen defined within a tubular sidewall. A tubular porous membrane is carried by the sidewall and extends across the proximal or distal end, so that debris entering the other end can be captured within the lumen, the membrane having a distribution of pore sizes. A control wire extends proximally from the filter. In use, the aorta may be cross clamped over the control wire or over the filter. Following removal of the cross clamp, blood is allowed to perfuse through the membrane in the direction of the descending aorta while retaining embolic debris therein for subsequent removal, and the filter and debris may be proximally retracted using the control wire.

Systems and methods can remove material of interest, including blood clots, from a body region, including but not limited to the circulatory system for the treatment of pulmonary embolism (PE), deep vein thrombosis (DVT), cerebrovascular embolism, and other vascular occlusions.

A thrombus engagement tool having a flexible shaft, a clot engagement tip, and a handle. The engagement tip may include one or more radially outwardly extending structures such as a helical thread. The helical thread can be advanced through a catheter to engage a clot. The handle may be configured to be rotated by hand. When the handle is rotated, the helical thread of the engagement tip can rotate in the same direction thereby allowing the helical threat to engage the clot. The helical thread can wrap around the flexible shaft at least about one, two, or four or more full revolutions, but in some cases no more than about ten or no more than about six revolutions.

Embolic protection device for insertion into an aortic arch, with a filter unit, a frame and a feed unit, wherein the filter unit is arranged at the frame and the frame provides a proximal area having a proximal shape, which is arranged in an inner area of the frame and is connected to the feed unit, wherein the proximal shape has a first part and a second part, wherein the second part is formed at one end of the first part.

Provided is an embolic protection device with dual-layer filter meshes, including an elastic base frame, a first filter mesh and a second filter mesh. The two ends of the first filter mesh are the first open end and the first closed end respectively. The distance between the first closed end and the elastic base frame is greater than the distance between the first open end and the elastic base frame. The first open end is connected with the elastic base frame, and the first filter mesh is provided with a plurality of first filtering holes. The second filter mesh is provided with a plurality of second filtering holes.

In some examples, a capture assembly configured to remove material of interest, including blood clots, from a body region, including but not limited to the circulatory system, includes a body configured to receive the material of interest. The body can be configured to axially lengthen and shorten.

Embolic material capture catheters and related devices and methods constrain a distal end portion of an embolic material capture element in an insertion configuration. A method of deploying an embolic material capture element in a blood vessel includes constraining a distal end portion of the embolic material capture element in an insertion configuration via engagement with a dilator assembly. The embolic material capture element, in the insertion configuration, is advanced through the blood vessel. A deployment cap of the dilator assembly is distally advanced relative to a dilator sheath of the dilator assembly to release the distal end portion of the embolic material capture element from engagement with the dilator assembly to reconfigure the embolic material capture element from the insertion configuration to a fully deployed configuration via self-expansion of the embolic material capture element.