Systems and methods can remove material of interest, including blood clots, from a body region, including but not limited to the circulatory system for the treatment of pulmonary embolism (PE), deep vein thrombosis (DVT), cerebrovascular embolism, and other vascular occlusions.

An accessory device may be used in combination with a thrombectomy catheter. The accessory device may be configured to deflect a distal portion of the thrombectomy catheter and/or disrupt a lesion in a vessel.

A distal stabilizer for use for catheter delivery in a biological lumen, the distal stabilizer comprising: a thread-like delivery member; and a locking device that extends from a distal end of the thread-like delivery member and is capable of locking onto an inner wall of the biological lumen with an expanding force. The distal stabilizer is usable in a catheter delivery operation including: releasing the locking device, which has been loaded in a first catheter while being in a reduced diameter state, from a distal end of the first catheter, thereby causing the locking device to lock onto the inner wall; and advancing a catheter including a second catheter having an inner diameter larger than the first catheter toward a distal side while the locking device remains locked on the inner wall. The distal stabilizer is configured such that after completion of the catheter delivery operation, the locking device is reduced in diameter to be resheathed into one of the catheters, and the distal stabilizer is removed out of the biological lumen.

Methods and devices are provided for protecting the cerebrovascular circulation from embolic debris released during an index procedure. An embolic protection filter is delivered in a reduced profile configuration via an access catheter, and positioned in the aorta spanning the ostia to the three great vessels leading to the cerebral circulation. An index procedure catheter is thereafter advanced through the same access catheter to conduct the index procedure. The index procedure may be a transcatheter aortic valve replacement.

A thrombus treatment device includes a support wire, a body frame portion that is disposed about an axis defined by the support wire, one or more tethers that each have a first end and a second end, and a filter element extending from the body frame portion. Each of the one or more tethers is attached at its first end to the body frame portion, and at its second end to a collar that couples the second end of each of the multiple tethers to the support wire. When the collar is positioned substantially within a region interior of the body frame portion, a rotational actuation of the support wire causes a swiveling motion of the one or more tethers.

A bristle device 8 for delivery into a body lumen comprises a longitudinally extending stem 1 and a plurality of bristles extending generally outwardly from the stem for anchoring the device in a body lumen. There may be at least two bristle segments 96 and there are flexible sections 95 between the segments 96. The flexible sections 95 articulate to enable the device to pass through a catheter placed in a tortuous anatomy or to be deployed in a curved vessel, or across a bifurcation. In some cases at least some of the bristle segments 96 are spaced-apart to accommodate bending of the bristles.

A clot removal device for removing a clot from a body vessel is presented. The device can facilitate clot retrieval by expanding in such a way as to engage the clot over a significant surface area. The clot can have at least one firm portion and at least one soft portion. At least one firm portion of the clot can be pinched by a proximal portion of the device while at least one soft portion of the clot can be retained by the distal portion of the device upon extraction. However, dislodgement and removal of the clot can cause softer portions the clot to shear or break, resulting in small floating fragments of clot in the vessel no longer attached to the main clot. This device can also capture and retain sheared or expanded distal portions of the clot upon removal of the clot from a vessel.

Embodiments of the present disclosure are directed to systems, methods and devices for providing embolic protection in a patient, and implantation of devices (and systems thereof) for enabling such functionality. In some embodiments, a device is configured for implantation in a body vessel including fluid flow. The device may assume, or be constrained to assume, an un-deployed state and a deployed state. In the un-deployed state, the device or a portion thereof is configured to reside in the lumen of a thin needle or cannula having a diameter of less than about 0.5 mm (for example). The needle may include a curved portion. In the deployed state, the device has an axis which, when implanted, is positioned approximately parallel to the fluid flow of the vessel. In some embodiments, the device comprises a thin filament body whereby in a deployed state, at least a portion of the filament takes on a helical shape. In some embodiments, at least one helix coil has height or pitch greater than the coil diameter. In some embodiments, the device has a monofilament filter portion including at least one coil whose center is off the helix axis. The device may be made of a super-elastic alloy so that the device can transition between the un-deployed and the deployed states without plastic deformation (in at least some embodiments). In some embodiments, the device is configured for transcatheter delivery.

A clot retrieval device is disclosed to remove clot from a blood vessel. The device can include a collapsed configuration and an expanded configuration. The device can include an inner expandable body with a framework of struts. The device can include an outer expandable body with a framework of struts that at least partially radially surrounding the inner expandable body. A distal portion of the outer expandable body can extend in the deployed configuration towards the outer expandable body to a greater extent than the inner expandable body, closed cells of the distal portion distally tapering and being smaller than cells proximal thereof in the outer expandable body. The plurality of closed cells of the distal portion can include a pair of axially aligned smaller diamond shaped cells formed by struts of the distal portion and positioned along upper and lower regions of the distal portion.

Clot removal from a patient's vessel, such as an artery, are described using aspiration and hydraulic forces supporting the removal process. Hydraulic forces can be generated by occluding the vessel distal to the clot and delivering liquid between the clot and the occlusive device. The aspiration catheter is positioned proximal to the clot. Catheters designed to facilitate the delivery of hydraulic forces can be based on single lumen designs or dual lumen designs. The catheters may have a fixed internal wire, or in some embodiments the catheters can ride over a wire with a valve/seal positioned to restrict flow into or out from the guide lumen such that the guide lumen can further function for balloon inflation and/or for infusion of liquid.