A diffractive multifocal lens is disclosed, comprising an optical element having at least one diffractive surface, the surface profile comprising a plurality of annular concentric zones. The optical thickness of the surface profile changes monotonically with radius within each zone, while a distinct step in optical thickness at the junction between adjacent zones defines a step height. The step heights for respective zones may differ from one zone to another periodically so as to tailor diffraction order efficiencies of the optical element, in one example of a trifocal lens, step heights alternate between two values, the even-numbered step heights being lower than the odd-numbered step heights. By plotting a topographical representation of the diffraction efficiencies resulting from such a surface profile, step heights may be optimized to direct a desired level of light power into the diffraction orders corresponding to near, intermediate, and distance vision, thereby optimizing the performance of the multifocal lens.

Intraocular implants and methods of making intraocular implants are disclosed. The intraocular implant can include a mask adapted to increase depth of focus. The method of manufacturing the implant can include filling an annular mask-forming trough with an opaque mask material and adding an optically transmissive optic material over the opaque mask material.

A storage/delivery device includes a first wall defining a well configured to receive a corneal tissue. The storage/delivery device includes a second wall configured to be positioned over the first wall and to seal the well. The second wall includes a recess configured to extend into the well to define a chamber between the first wall and the second wall. The chamber is configured to hold the corneal tissue when the second wall seals the well. A system may include the storage/delivery device above and a measurement system configured to measure the corneal tissue disposed in the well. In one example embodiment, the measurement system is an optical coherence tomography (OCT) system. In another example embodiment, the measurement system is a second-harmonic generation (SHG) or third-harmonic generation (THG) microscopy system.

Reversibly deformable corneal implants for replacing excised corneal tissue, the implants including an optical portion and an anchoring portion having different mechanical properties from each other.

A method of lamellar corneal graft implantation is disclosed herein. In one or more embodiments, the method includes the steps of: (i) modifying a genetic component of a lamellar cornea or other tissue of an animal so that the lamellar cornea or other tissue of the animal can be used for human transplantation; (ii) decellularizing the lamellar cornea or other tissue ex vivo using chemical means; (iii) modifying a shape of the lamellar cornea or other tissue before or after transplantation; and (iv) applying a photosensitizer and ultraviolet radiation to the lamellar cornea or other tissue so as to crosslink collagen and intercellular proteins of the lamellar cornea or other tissue, kill the cells exposed to the photosensitizer, and eliminate an immune response by a host to the implanted lamellar cornea or the tissue.

An ablatable corneal inlay for correction of refractive errors and/or presbyopia, and a method of correcting refractive errors and presbyopia in an eye of a patient using an ablatable corneal inlay is disclosed herein.

Methods for treating presbyopia in a patient's eye involve inducing spherical aberration in a central area of the pupil. In embodiments, refractive properties of an eye are measured to obtain a baseline refractive correction. A lens for wearing on the eye is provided, or an optical device is implanted in the eye, or corneal tissue is removed to create spherical aberration or a distribution of spherical aberrations beyond the baseline refractive correction in the central area of the pupil. The central area of the pupil has a diameter of between 1.5 mm and 4.0 mm and has negligible spherical aberration without the treatment.

A device for reducing the incidence of surgical debris migration within a mammalian eye comprising an anterior portion, the anterior portion with an anterior inner surface and an opposing anterior outer surface, the anterior inner surface and the anterior outer surface terminating at an anterior edge that defines an open anterior end; and a posterior portion, with a posterior inner surface and an opposing posterior outer surface, the posterior inner surface and the posterior outer surface terminating at a posterior edge, the posterior edge defining an open posterior end; and a waist connecting the anterior portion and the posterior portion, the waist comprising a waist inner surface and an opposing waist outer surface; and an aperture extending from the open anterior end, through the waist, and to the open posterior end, the aperture bounded by the anterior inner surface, the waist inner surface, and the posterior inner surface.

A device for reducing the incidence of surgical debris migration within a mammalian eye comprising an anterior portion, the anterior portion with an anterior inner surface and an opposing anterior outer surface, the anterior inner surface and the anterior outer surface terminating at an anterior edge that defines an open anterior end; and a posterior portion, with a posterior inner surface and an opposing posterior outer surface, the posterior inner surface and the posterior outer surface terminating at a posterior edge, the posterior edge defining an open posterior end; and a waist connecting the anterior portion and the posterior portion, the waist comprising a waist inner surface and an opposing waist outer surface; and an aperture extending from the open anterior end, through the waist, and to the open posterior end, the aperture bounded by the anterior inner surface, the waist inner surface, and the posterior inner surface.

The invention provides an isolated dehydrated corneal tissue, comprising a full thickness corneal stroma, and substantially all, or all, of the Bowman's membrane, wherein the stroma contains cellular material. Also provided is a method to product the tissue and uses of the tissue.