The present disclosure provides compounds and methods for inhibiting or degrading the N-terminal domain of the androgen receptor, as well as methods for treating cancers such as prostate cancer.

A fluorine-containing ether compound represented by Formula (1) is provided;

R.sup.1R.sup.2CH.sub.2R.sup.3CH.sub.2R.sup.4R.sup.5(1)

(In Formula (1), R.sup.1 and R.sup.5 may be the same as or different from each other and each represents an alkenyl group having 2 to 8 carbon atoms or an alkynyl group having 3 to 8 carbon atoms, R.sup.2 and R.sup.4 may be the same as or different from each other and each represents a divalent linking group having a polar group, and R.sup.3 represents a perfluoropolyether chain, with a proviso that R.sup.1 and R.sup.2 are, and R.sup.4 and R.sup.5 are divided due to the presence of an atom other than the carbon atom such as an oxygen atom).

Synthetic methods for the preparation of ligands and metal-ligand complexes are disclosed.

The present invention relates to a fluorine-containing ether compound represented by Formula (1),

R.sup.1R.sup.2CH.sub.2R.sup.3CH.sub.2R.sup.4(1).

(In Formula (1), R.sup.1 is an end group including an organic group having at least one double bond or triple bond, R.sup.2 is a divalent linking group bonded to R.sup.1 by etheric oxygen, R.sup.3 is a perfluoropolyether chain, R.sup.4 is an end group having two or three polar groups with each polar group being bonded to different carbon atoms, and the carbon atoms, to which the polar groups are bonded, being bonded to each other via a linking group including carbon atoms to which the polar groups are not bonded.)

The present disclosure provides compounds of Formula (VIIb) and methods for inhibiting or degrading the N-terminal domain of the androgen receptor, as well as methods for treating cancers such as prostate cancer. ##STR00001##

The present invention relates to brominated polyether polyols, processes for the production as well as intermediates useful in the production of the same and to processes for the preparation of flame-retardant blends, premixes as well as polyurethane foams.

Compounds [compounds (L)] comprising at least one monocyclic, polycyclic or polycondensed aromatic moiety [moiety (A*)], wherein: at least one carbon atom of moiety (A*) is substituted with a fluoropolyoxyalkene chain [chain (R.sub.f)], said chain (R.sub.f) comprising: a) a fluorocarbon segment having ether linkages in the main chain and b) at least one hydroxyl group and wherein: at least one other carbon atom of moiety (A*) is substituted with an electron-withdrawing group and mixtures thereof are herein disclosed. Disclosed are also a process for manufacturing compounds (L), a method for lubricating MRM comprising using compounds (L), a lubricant composition comprising one or more compounds (L) and a method for manufacturing a composition (C).

To provide a method capable of separating a monofunctional species, bifunctional species, etc. of a fluorinated ether compound having a polyfluoropolyether chain and a predetermined functional group in good yield and with high separation performance. A separation method for separating a compound represented by the formula (1) and a compound represented by the formula (2) from a mixture containing them by chromatography using a stationary phase and a mobile phase, wherein the mobile phase contains at least one type of specific solvent selected from a hydrofluoroolefin, a hydrochlorofluoroolefin, a chlorofluoroolefin, a cyclic hydrofluoroolefin, a cyclic hydrochlorofluoroolefin, a cyclic chlorofluoroolefin, a cyclic hydrofluorocarbon, a cyclic hydrochlorofluorocarbon, a cyclic chlorofluorocarbon and a perfluoroketone:
A-(OX).sub.mOZ(R).sub.n1Formula (1)
(R).sub.n2Z(OX).sub.mOZ(R).sub.n3Formula (2)

To provide a method capable of separating a monofunctional species, bifunctional species, etc. of a fluorinated ether compound having a polyfluoropolyether chain and a predetermined functional group in good yield and with high separation performance. A separation method for separating a compound represented by the formula (1) and a compound represented by the formula (2) from a mixture containing them by chromatography using a stationary phase and a mobile phase, wherein the mobile phase contains at least one type of specific solvent selected from a hydrofluoroolefin, a hydrochlorofluoroolefin, a chlorofluoroolefin, a cyclic hydrofluoroolefin, a cyclic hydrochlorofluoroolefin, a cyclic chlorofluoroolefin, a cyclic hydrofluorocarbon, a cyclic hydrochlorofluorocarbon, a cyclic chlorofluorocarbon and a perfluoroketone:
A-(OX).sub.mOZ(R).sub.n1Formula (1)
(R).sub.n2Z(OX).sub.mOZ(R).sub.n3Formula (2)