A system for geographic mobile customer relations management, using a mobile customer relations management system manager connected to at least one mobile-capable network-connected computing device configured to graphically identify, manage and update customer relations management data in a geographic context and configured to organize customer relations management data based on at least one specific real-time queried variable using a selective graphical encapsulating function and/or graphical query mode to yield optimal routes to location-based customers, with an option to optimize schedules and appointments based on real-time customer relations management data available in a customer relations management system.

The present invention relates to: a method for converting a hydroxyl group of an alcohol; and a catalyst which makes the method possible. A method for converting a hydroxyl group of an alcohol according to the present invention is characterized by producing a compound represented by CH(R.sup.1)(R.sup.2)Nu (wherein R.sup.1, R.sup.2 and Nu are as defined below) by reacting an alcohol represented by CH(R.sup.1)(R.sup.2)OH (wherein each of R.sup.1 and R.sup.2 represents a hydrogen atom, an optionally substituted alkyl group, or the like) and a compound having an active proton, which is represented by H-Nu (wherein Nu represents a group represented by —CHX.sup.1-EWG.sup.1 or —NR.sup.3R.sup.4; X.sup.1 represents a hydrogen atom or the like; EWG.sup.1 represents an electron-withdrawing group; and each of R.sup.3 and R.sup.4 represents a hydrogen atom, an optionally substituted alkyl group, or the like), with each other in the presence of a complex of a group 7-11 metal of the periodic table and at least one solid base that is selected from the group consisting of layered double hydroxides, composite oxides and calcium hydroxide.

The present invention relates to: a method for converting a hydroxyl group of an alcohol; and a catalyst which makes the method possible. A method for converting a hydroxyl group of an alcohol according to the present invention is characterized by producing a compound represented by CH(R.sup.1)(R.sup.2)Nu (wherein R.sup.1, R.sup.2 and Nu are as defined below) by reacting an alcohol represented by CH(R.sup.1)(R.sup.2)OH (wherein each of R.sup.1 and R.sup.2 represents a hydrogen atom, an optionally substituted alkyl group, or the like) and a compound having an active proton, which is represented by H-Nu (wherein Nu represents a group represented by —CHX.sup.1-EWG.sup.1 or —NR.sup.3R.sup.4; X.sup.1 represents a hydrogen atom or the like; EWG.sup.1 represents an electron-withdrawing group; and each of R.sup.3 and R.sup.4 represents a hydrogen atom, an optionally substituted alkyl group, or the like), with each other in the presence of a complex of a group 7-11 metal of the periodic table and at least one solid base that is selected from the group consisting of layered double hydroxides, composite oxides and calcium hydroxide.

The present invention relates to: a method for converting a hydroxyl group of an alcohol; and a catalyst which makes the method possible. A method for converting a hydroxyl group of an alcohol according to the present invention is characterized by producing a compound represented by CH(R.sup.1)(R.sup.2)Nu (wherein R.sup.1, R.sup.2 and Nu are as defined below) by reacting an alcohol represented by CH(R.sup.1)(R.sup.2)OH (wherein each of R.sup.1 and R.sup.2 represents a hydrogen atom, an optionally substituted alkyl group, or the like) and a compound having an active proton, which is represented by H-Nu (wherein Nu represents a group represented by —CHX.sup.1-EWG.sup.1 or —NR.sup.3R.sup.4; X.sup.1 represents a hydrogen atom or the like; EWG.sup.1 represents an electron-withdrawing group; and each of R.sup.3 and R.sup.4 represents a hydrogen atom, an optionally substituted alkyl group, or the like), with each other in the presence of a complex of a group 7-11 metal of the periodic table and at least one solid base that is selected from the group consisting of layered double hydroxides, composite oxides and calcium hydroxide.

A method for forming a desired hydrocarbon fuel product from a mixed oxygenate feedstock by utilizing chemical processes to form ketones from the oxygenate feed, upgrade the ketones, recycle selected upgraded ketones through the upgrading process to obtain a desired intermediate and hydrogenating the desired intermediate to obtain the desired hydrocarbon fuel product. In various alternative configurations and embodiments this can be accomplished in a number of ways, and originate in a number of different positions and occasions.

A method for forming a desired hydrocarbon fuel product from a mixed oxygenate feedstock by utilizing chemical processes to form ketones from the oxygenate feed, upgrade the ketones, recycle selected upgraded ketones through the upgrading process to obtain a desired intermediate and hydrogenating the desired intermediate to obtain the desired hydrocarbon fuel product. In various alternative configurations and embodiments this can be accomplished in a number of ways, and originate in a number of different positions and occasions.

The present application provides methods for the synthesis of intermediates in the synthesis of Safinamide or a pharmaceutically acceptable salt thereof herein Safinamide Mesylate, that is substantially free of impurities.

The present application provides methods for the synthesis of intermediates in the synthesis of Safinamide or a pharmaceutically acceptable salt thereof herein Safinamide Mesylate, that is substantially free of impurities.

The present application provides methods for the synthesis of intermediates in the synthesis of Safinamide or a pharmaceutically acceptable salt thereof herein Safinamide Mesylate, that is substantially free of impurities.

The present invention discloses a nicotinyl alcohol ether derivative, a preparation method therefor, and a pharmaceutical composition and uses thereof. Specifically, the invention relates to nicotinyl alcohol ether derivatives represented by formula (I), a pharmaceutically-acceptable salt thereof, a stereoisomer thereof, a preparation method therefor, a pharmaceutical composition containing the one or more compounds, and uses of the compounds in treating diseases related to PD-1/PD-L1 signal channels, such as cancers, infectious diseases and autoimmune diseases.

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