Inhibitors of SARS-COV-2 (COVID), pharmaceutical compositions comprising same; and methods of treating a severe acute respiratory syndrome.

Inhibitors of SARS-COV-2 (COVID), pharmaceutical compositions comprising same; and methods of treating a severe acute respiratory syndrome.

Inhibitors of SARS-CoV-2 (COVID), pharmaceutical compositions comprising same; and methods of treating a severe acute respiratory syndrome.

Inhibitors of SARS-CoV-2 (COVID), pharmaceutical compositions comprising same; and methods of treating a severe acute respiratory syndrome.

Benzenesulfonamide derivatives of formula (I), the pharmaceutically acceptable addition salts thereof, the hydrates and/or solvates thereof, and the use of same as inverse agonist of retinoid-related orphan receptor gamma (RORt) are described. A pharmaceutical composition including such compounds, as well as the use thereof for the topical and/or oral treatment of RORt receptor-medicated inflammatory diseases, in particular acne, psoriasis and/or atopic dermatitis are also described.

Benzenesulfonamide derivatives of formula (I), the pharmaceutically acceptable addition salts thereof, the hydrates and/or solvates thereof, and the use of same as inverse agonist of retinoid-related orphan receptor gamma (RORt) are described. A pharmaceutical composition including such compounds, as well as the use thereof for the topical and/or oral treatment of RORt receptor-medicated inflammatory diseases, in particular acne, psoriasis and/or atopic dermatitis are also described.

Provided are methods of treating a cancer characterized by the presence of a mutant allele of IDH1/2 comprising administering to a subject in need thereof a compound described here.

Provided are methods of treating a cancer characterized by the presence of a mutant allele of IDH1/2 comprising administering to a subject in need thereof a compound described here.

Disclosed are compounds of Formula 1, including all N-oxides, stereoisomers, and salts thereof, ##STR00001##
wherein Q.sup.1, Q.sup.2, R.sup.1, R.sup.2, Y, J and R.sup.7 are as defined in the disclosure. Also disclosed are compositions containing the compounds of Formula 1 and methods for controlling undesired vegetation comprising contacting the undesired vegetation or its environment with an effective amount of a compound or a composition of the invention.

The present invention relates to a new process for preparing brivaracetam. (Ib) ##STR00001##