Patent classifications
C07D209/24
INDOLE CARBOXAMIDE COMPOUND, PREPARATION THEREFOR AND USE THEREOF
The present invention relates to an indole carboxamide compound, preparation therefor and use thereof. The indole carboxamide is represented by the following general formula (I). The compound of the present invention is more stable and active and can be used for prophylaxis or treatment of nephropathy, sepsis, arthritis, pulmonary hypertension or tumor.
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INDOLE CARBOXAMIDE COMPOUND, PREPARATION THEREFOR AND USE THEREOF
The present invention relates to an indole carboxamide compound, preparation therefor and use thereof. The indole carboxamide is represented by the following general formula (I). The compound of the present invention is more stable and active and can be used for prophylaxis or treatment of nephropathy, sepsis, arthritis, pulmonary hypertension or tumor.
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PSMA-targeted NIR dyes and their uses
The present disclosure relates to prostate specific membrane antigen (PSMA) targeted compounds conjugated to near-infra red (NIR) dyes and methods for a method for synthesizing a compound of the formula: ##STR00001##
PSMA-targeted NIR dyes and their uses
The present disclosure relates to prostate specific membrane antigen (PSMA) targeted compounds conjugated to near-infra red (NIR) dyes and methods for a method for synthesizing a compound of the formula: ##STR00001##
Low-molecular-compound for improving production, maintenance and proliferation of pluripotent stem cells, composition comprising the same, and culture method
Provided herein are novel indoleacrylic acid-based compounds, and pharmaceutically acceptable salts thereof, useful for the production, maintenance and proliferation of pluripotent stem cells. Also provided are cell culture compositions comprising these compounds, and methods of using these compounds in the production and maintenance of pluripotent stem cells.
Low-molecular-compound for improving production, maintenance and proliferation of pluripotent stem cells, composition comprising the same, and culture method
Provided herein are novel indoleacrylic acid-based compounds, and pharmaceutically acceptable salts thereof, useful for the production, maintenance and proliferation of pluripotent stem cells. Also provided are cell culture compositions comprising these compounds, and methods of using these compounds in the production and maintenance of pluripotent stem cells.
ASH1L DEGRADERS AND METHODS OF TREATMENT THEREWITH
Provided herein are small molecules comprising a first domain that binds to ASH1L and a second domain that facilitates ASH1L degradation. In particular, ASH1L-targeting proteolysis targeting chimeras (PROTACs) and methods of use thereof for the treatment of disease (e.g., acute leukemia, solid cancers and other diseases dependent on activity of ASH1L) are provided.
ASH1L INHIBITORS AND METHODS OF TREATMENT THEREWITH
Provided herein are small molecules that bind to ASH1L and inhibit ASH1L activity, and methods of use thereof for the treatment of disease, including acute leukemia, solid cancers and other diseases dependent on activity of ASH1L.
ASH1L INHIBITORS AND METHODS OF TREATMENT THEREWITH
Provided herein are small molecules that bind to ASH1L and inhibit ASH1L activity, and methods of use thereof for the treatment of disease, including acute leukemia, solid cancers and other diseases dependent on activity of ASH1L.
SMALL MOLECULE N-(ALPHA-PEROXY) INDOLE COMPOUNDS AND METHODS OF USE
The invention relates to novel N-(-peroxy)indole compounds of Formula I and methods for use. (I) The N-(-peroxy)indole compounds described herein are useful for treating or preventing parastic infections, bacterial infections, and cancer in subjects. The methods include administering an N-(-peroxy)indole compound as described herein to a subject. Also described herein are methods for synthesizing N-(-peroxy)indole compounds.
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