Among other things, the present disclosure provides compounds, e.g., of formula I or salts thereof. In some embodiments, the present disclosure provides methods for modulating MRGPRX4 activity. In some embodiments, the present disclosure provides methods for preventing or treating conditions, disorders or diseases, e.g., MRGPRX4-associated conditions, disorders or diseases.

The present invention relates to a method for labeling or targeting cells whose plasma membrane has lost integrity, such as dead cells, such as for discriminating between live cells and cells whose plasma membrane has lost integrity; to an embodiment of the method for determining one or more values of one or more parameters of cells of a biological sample; to use of the method in an assay for screening drugs for therapy such as cancer therapy; to use of the method to monitor and/or determine the effectiveness of a therapy; to an assay kit; to a complex; to the complex for use as a medicament; to the complex for use in treatment of cancer(s) and/or plaque(s) and/or regeneration and/or supporting the immune system; and, to a dead cell.

The present invention relates to a method for labeling or targeting cells whose plasma membrane has lost integrity, such as dead cells, such as for discriminating between live cells and cells whose plasma membrane has lost integrity; to an embodiment of the method for determining one or more values of one or more parameters of cells of a biological sample; to use of the method in an assay for screening drugs for therapy such as cancer therapy; to use of the method to monitor and/or determine the effectiveness of a therapy; to an assay kit; to a complex; to the complex for use as a medicament; to the complex for use in treatment of cancer(s) and/or plaque(s) and/or regeneration and/or supporting the immune system; and, to a dead cell.

##STR00001##

The invention relates to novel compounds having the general formula (I), wherein R.sup.1, R.sup.10, R.sup.x, R.sup.y, Y, m, and n are as described herein, composition including the compounds and methods of using the compounds.

##STR00001##

The invention relates to novel compounds having the general formula (I), wherein R.sup.1, R.sup.10, R.sup.x, R.sup.y, Y, m, and n are as described herein, composition including the compounds and methods of using the compounds.

Provided herein are small molecules that bind to ASH1L and inhibit ASH1L activity, and methods of use thereof for the treatment of disease, including acute leukemia, solid cancers and other diseases dependent on activity of ASH1L.

Provided herein are small molecules that bind to ASH1L and inhibit ASH1L activity, and methods of use thereof for the treatment of disease, including acute leukemia, solid cancers and other diseases dependent on activity of ASH1L.

A method of synthesizing a fluorophore is disclosed. The method includes the steps of converting a heptamethine dye to a keto-heptamethine dye and converting the keto-heptamethine dye to a 4-aryl heptamethine dye.

A method of synthesizing a fluorophore is disclosed. The method includes the steps of converting a heptamethine dye to a keto-heptamethine dye and converting the keto-heptamethine dye to a 4-aryl heptamethine dye.