Patent classifications
C07D209/24
PSMA TARGETED FLUORESCENT AGENTS FOR IMAGE GUIDED SURGERY
Compositions and methods for visualizing tissue under illumination with near-infrared radiation, including compounds comprising near-infrared, closed chain, sulfo-cyanine dyes and prostate specific membrane antigen ligands are disclosed.
PROCESS FOR THE PREPARATION OF ZAFIRLUKAST AND ANALOGS THEREOF
The present invention relates to a process for the preparation of (1-alkylindo-3-ylmethyl) benzoic acid derivatives, in particular Zafirlukast and analogs thereof. Further, this process is based on protection group free and CH bond activation strategy involving all step catalytic transformation sequence and comprises the following steps: Sonogashira coupling, indole formation by Sp.sup.3 CH activation, reductive hydrogenation and amidation.
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Small molecule N-(alpha-peroxy) indole compounds and methods of use
The invention relates to novel N-(-peroxy)indole compounds of Formula I and methods for use. (I) The N-(-peroxy)indole compounds described herein are useful for treating or preventing parastic infections, bacterial infections, and cancer in subjects. The methods include administering an N-(-peroxy)indole compound as described herein to a subject. Also described herein are methods for synthesizing N-(-peroxy)indole compounds. ##STR00001##
Small molecule N-(alpha-peroxy) indole compounds and methods of use
The invention relates to novel N-(-peroxy)indole compounds of Formula I and methods for use. (I) The N-(-peroxy)indole compounds described herein are useful for treating or preventing parastic infections, bacterial infections, and cancer in subjects. The methods include administering an N-(-peroxy)indole compound as described herein to a subject. Also described herein are methods for synthesizing N-(-peroxy)indole compounds. ##STR00001##
Compounds and methods for the synthesis of 5-(N-protected-tryptaminocarboxyamide)-2′-deoxyuridine phosphoramidite for incorporation into a nucleic acid
Modified Tryptamine, Tryptamine-2-deoxy-uridine (TrpdU) and TrpdU-phosphoramidites for oligonucleotide synthesis are provided, as well as improved methods of their synthesis and oligonucleotides comprising at least one modified TrpdU nucleotide.
Compounds and methods for the synthesis of 5-(N-protected-tryptaminocarboxyamide)-2′-deoxyuridine phosphoramidite for incorporation into a nucleic acid
Modified Tryptamine, Tryptamine-2-deoxy-uridine (TrpdU) and TrpdU-phosphoramidites for oligonucleotide synthesis are provided, as well as improved methods of their synthesis and oligonucleotides comprising at least one modified TrpdU nucleotide.
EPAC1 activators as HIV latency reversal agents (LRA)
The invention relates generally to novel EPAC1 activators, such as Formula I and the preparation thereof as well as the use of EPAC1 activators as human immunodeficiency virus (HIV) latency reversal agents (LRAs). ##STR00001##
EPAC1 activators as HIV latency reversal agents (LRA)
The invention relates generally to novel EPAC1 activators, such as Formula I and the preparation thereof as well as the use of EPAC1 activators as human immunodeficiency virus (HIV) latency reversal agents (LRAs). ##STR00001##
ASH1L inhibitors and methods of treatment therewith
Provided herein are small molecules that bind to ASH1L and inhibit ASH1L activity, and methods of use thereof for the treatment of disease, including acute leukemia, solid cancers and other diseases dependent on activity of ASH1L.
ASH1L inhibitors and methods of treatment therewith
Provided herein are small molecules that bind to ASH1L and inhibit ASH1L activity, and methods of use thereof for the treatment of disease, including acute leukemia, solid cancers and other diseases dependent on activity of ASH1L.