The present invention concerns substituted indoline derivatives, methods to prevent or treat dengue viral infections by using said compounds and also relates to said compounds for use as a medicine, more preferably for use as a medicine to treat or prevent dengue viral infections. The present invention furthermore relates to pharmaceutical compositions or combination preparations of the compounds, to the compositions or preparations for use as a medicine, more preferably for the prevention or treatment of dengue viral infections. The invention also relates to processes for preparation of the compounds.

##STR00001##

The present invention concerns substituted indoline derivatives, methods to prevent or treat dengue viral infections by using said compounds and also relates to said compounds for use as a medicine, more preferably for use as a medicine to treat or prevent dengue viral infections. The present invention furthermore relates to pharmaceutical compositions or combination preparations of the compounds, to the compositions or preparations for use as a medicine, more preferably for the prevention or treatment of dengue viral infections. The invention also relates to processes for preparation of the compounds.

##STR00001##

A method for separating one or more amino acids from a whole stillage byproduct produced in a corn dry milling process for making alcohol and system therefore is disclosed. In one embodiment, the method includes separating the whole stillage byproduct into an insoluble solids portion and a thin stillage portion, which include protein and amino acids. Thereafter, the thin stillage portion can be separated into a water soluble solids portion and a protein and amino acids portion. The resulting protein and amino acids portion can be separated into an amino acid(s) portion and a protein portion, both of which may be optionally dried, utilizing microfiltration, ultrafiltration, electrophoresis techniques/devices, or combinations thereof. The amino acid(s) in the resulting amino acid(s) portion may be further processed to be sold and/or used as or in, for example, nutritional supplements, flavor enhancers, animal feed additives, pharmaceuticals, industrial usage, fertilizers, herbicides, or as a feed source for other processing systems.

A method for separating one or more amino acids from a whole stillage byproduct produced in a corn dry milling process for making alcohol and system therefore is disclosed. In one embodiment, the method includes separating the whole stillage byproduct into an insoluble solids portion and a thin stillage portion, which include protein and amino acids. Thereafter, the thin stillage portion can be separated into a water soluble solids portion and a protein and amino acids portion. The resulting protein and amino acids portion can be separated into an amino acid(s) portion and a protein portion, both of which may be optionally dried, utilizing microfiltration, ultrafiltration, electrophoresis techniques/devices, or combinations thereof. The amino acid(s) in the resulting amino acid(s) portion may be further processed to be sold and/or used as or in, for example, nutritional supplements, flavor enhancers, animal feed additives, pharmaceuticals, industrial usage, fertilizers, herbicides, or as a feed source for other processing systems.

The invention relates to novel N-(-peroxy)indole compounds of Formula I and methods for use. (I) The N-(-peroxy)indole compounds described herein are useful for treating or preventing parastic infections, bacterial infections, and cancer in subjects. The methods include administering an N-(-peroxy)indole compound as described herein to a subject. Also described herein are methods for synthesizing N-(-peroxy)indole compounds. ##STR00001##

The invention relates to novel N-(-peroxy)indole compounds of Formula I and methods for use. (I) The N-(-peroxy)indole compounds described herein are useful for treating or preventing parastic infections, bacterial infections, and cancer in subjects. The methods include administering an N-(-peroxy)indole compound as described herein to a subject. Also described herein are methods for synthesizing N-(-peroxy)indole compounds. ##STR00001##

The present disclosure relates to compounds that are capable of inhibiting the mitochondrial pyruvate carrier and promoting hair growth. The disclosure further relates to methods of promoting hair growth or treating conditions or disorders affecting hair growth, such as baldness or alopecia.

Disclosed herein is a process for making a compound of formula (2) by (hetero)aromatic CH hydroxylation of a compound of formula (1): catalyzed by palladium(II) and a bidentate ligand in the presence of O.sub.2. The process is useful for instance, in the late-stage modification of medicinally important heterocycles.

##STR00001##

Disclosed herein is a process for making a compound of formula (2) by (hetero)aromatic CH hydroxylation of a compound of formula (1): catalyzed by palladium(II) and a bidentate ligand in the presence of O.sub.2. The process is useful for instance, in the late-stage modification of medicinally important heterocycles.

##STR00001##

The present disclosure relates to indole compounds and pharmaceutical compositions thereof, and their use in stimulating the immune system of patients in need thereof and in treating cancer.