The present invention provides N-substituted indoles and other heterocycles and methods of using the compounds for treating brain disorders.

Amphiphilic compounds with tetradecahydrophenanthrene skeleton and their enantiomers, exhibiting neuroprotective effects, their use in methods of treatment of neuropsychiatric disorders associated with an imbalance in glutamatergic neurotransmitter system, such as ischemic damage of CNS, neurodegenerative changes and disorders of CNS, affective disorders, depression, post-traumatic stress disorder and diseases related to stress, anxiety, schizophrenia and psychotic disorders, pain, addiction, multiple sclerosis, epilepsy, glioma, and a pharmaceutical composition containing compound.

Therapeutic compositions comprising one or more agents that inhibit CXXC5-DVL interface, and methods of administering those therapeutic compositions to model, treat, reduce resistance to treatment, prevent, and diagnose a condition/disease associated with a metabolic disease or a related clinical condition thereof, are disclosed.

Polymorphs of 5-bromo-6-chloro-3-indoxyl caprylate characterized by the powder diffraction patterns as defined in FIG. 1 and FIG. 2.

Polymorphs of 5-bromo-6-chloro-3-indoxyl caprylate characterized by the powder diffraction patterns as defined in FIG. 1 and FIG. 2.

Disclosed is a method for preparing adrenochrome by catalytic oxidation using nitrogen-doped carbon nanotubes. The method catalyzes dissolved oxygen in an aqueous solution by the nitrogen-doped carbon nanotubes to rapidly oxidize adrenaline, which is completely transformed into adrenochrome. It is a novel preparation process of adrenochrome, which is simple, and has mild reaction conditions, high product purity, an impurity content less than 10.sup.−8%, and low subsequent processing cost, thereby having a great application prospect. The nitrogen-doped carbon tubes after use can be regenerated and recovered, and its reutilization is still able to realize the complete transformation of adrenaline. The high utilization rate of catalytic material conforms to the concept of energy conservation, minimizing the costs.

Disclosed is a method for preparing adrenochrome by catalytic oxidation using nitrogen-doped carbon nanotubes. The method catalyzes dissolved oxygen in an aqueous solution by the nitrogen-doped carbon nanotubes to rapidly oxidize adrenaline, which is completely transformed into adrenochrome. It is a novel preparation process of adrenochrome, which is simple, and has mild reaction conditions, high product purity, an impurity content less than 10.sup.−8%, and low subsequent processing cost, thereby having a great application prospect. The nitrogen-doped carbon tubes after use can be regenerated and recovered, and its reutilization is still able to realize the complete transformation of adrenaline. The high utilization rate of catalytic material conforms to the concept of energy conservation, minimizing the costs.

The present invention provides N-substituted indoles and other heterocycles and methods of using the compounds for treating brain disorders.

A compound having one of the following structures of Formula (IV) or (V): ##STR00001##
or a stereoisomer, salt, or tautomer thereof, wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5 R.sub.6, R.sub.7, R.sub.8, R.sub.10, R.sub.11a R.sub.11b, R.sub.12a R.sub.12b, X, Y, and Z are as defined herein. Pharmaceutical composition comprising the compounds, and their use in methods of treating diseases are also described.

A compound having one of the following structures of Formula (IV) or (V): ##STR00001##
or a stereoisomer, salt, or tautomer thereof, wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5 R.sub.6, R.sub.7, R.sub.8, R.sub.10, R.sub.11a R.sub.11b, R.sub.12a R.sub.12b, X, Y, and Z are as defined herein. Pharmaceutical composition comprising the compounds, and their use in methods of treating diseases are also described.