The present invention provides an improved process for the preparation of Apremilast using novel intermediates. The present invention also relates to the novel crystalline polymorphic form of Apremilast.

Provided herein are compounds of the formula (I) as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of degenerative diseases and disorders. ##STR00001##

Provided herein are compounds of the formula (I) as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of degenerative diseases and disorders. ##STR00001##

A compound having one of the following structures of Formula (IV) or (V):

##STR00001##

or a stereoisomer, salt, or tautomer thereof, wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5 R.sub.6, R.sub.7, R.sub.8, R.sub.10, R.sub.11a R.sub.11b, R.sub.12a R.sub.12b, X, Y, and Z are as defined herein. Pharmaceutical composition comprising the compounds, and their use in methods of treating diseases are also described.

A compound having one of the following structures of Formula (IV) or (V):

##STR00001##

or a stereoisomer, salt, or tautomer thereof, wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5 R.sub.6, R.sub.7, R.sub.8, R.sub.10, R.sub.11a R.sub.11b, R.sub.12a R.sub.12b, X, Y, and Z are as defined herein. Pharmaceutical composition comprising the compounds, and their use in methods of treating diseases are also described.

Among the various aspects of the present disclosure is the provision of a transgenic organism, an artificial DNA construct, and methods for producing a transgenic organism for indigo, indirubin, and other indole-derived compound production. Another aspect of the present disclosure is the provision of a transgenic organism wherein the indole-derived compound imparts color to the transgenic organism or to a portion of the transgenic organism.

Among the various aspects of the present disclosure is the provision of a transgenic organism, an artificial DNA construct, and methods for producing a transgenic organism for indigo, indirubin, and other indole-derived compound production. Another aspect of the present disclosure is the provision of a transgenic organism wherein the indole-derived compound imparts color to the transgenic organism or to a portion of the transgenic organism.

The present invention relates to novel compounds which are capable of inhibiting certain amine oxidase enzymes. These compounds are useful for treatment of a variety of indications, e.g., fibrosis, cancer and/or angiogenesis in human subjects as well as in pets and livestock. In addition, the present invention relates to pharmaceutical compositions containing these compounds, as well as various uses thereof.

The present invention relates to novel compounds which are capable of inhibiting certain amine oxidase enzymes. These compounds are useful for treatment of a variety of indications, e.g., fibrosis, cancer and/or angiogenesis in human subjects as well as in pets and livestock. In addition, the present invention relates to pharmaceutical compositions containing these compounds, as well as various uses thereof.

The present disclosure discloses a compound of Formula I and the process of preparation thereof. The present disclosure discloses indirubin compounds of Formula I which are potent inducers of autophagy. The present disclosure also discloses a pharmaceutical composition comprising compound of Formula I and methods thereof.