The present invention relates to novel sulfur derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals as modulators of chemokine receptors.

The present invention relates to novel sulfur derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals as modulators of chemokine receptors.

The present invention refers to a process for a catalytic aryl transfer to rearrange the backbone of aromatic C—X bonds.

The present invention relates to a benzamide compound and a preparation method, use and pharmaceutical composition thereof. The benzamide compound represented by formula (I) is a STAT3 inhibitor, and can be used to prevent and/or treat a disease related to STAT3 activity, such as a tumor, autoimmune disease, renal disease, cardiovascular disease, inflammation, metabolic/endocrine dysfunction, and neurological disease.

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The present disclosure is directed to methods for treating diseases for which cysteamine is indicated and compounds useful in such methods.

The present disclosure is directed to methods for treating diseases for which cysteamine is indicated and compounds useful in such methods.

An aqueous composition comprising (a) metal ions comprising tin ions and silver ions and (b) at least one complexing agent of formula (C1) R.sup.1X.sup.1SX.sup.21[D.sup.1-X.sup.22].sub.nSX.sup.3R.sup.2, (C2) R.sup.1X.sup.1SX.sup.31-D.sup.2-[X.sup.32S].sub.nX.sup.3R.sup.2, (C3) R.sup.3X.sup.1SX.sup.41-[D.sup.3X.sup.42].sub.nSX.sup.3R.sup.4 wherein X.sup.1, X.sup.3 are independently selected from a linear or branched C.sub.1-C.sub.12 alkanediyl, which may be unsubstituted or substituted by OH; X.sup.21, X.sup.22 are independently selected from X.sup.1, which may be further substituted by X.sup.5COOR.sup.12, X.sup.5SO.sub.2OR.sup.12, a C.sub.2 to C.sub.6 polyoxyalkylene group of formula (OCH.sub.2CHR.sup.11).sub.zOH, or a combination thereof, and X.sup.1NHCOX.sup.6CONHX.sup.1; X.sup.31, X.sup.32 are independently selected from a chemical bond and X.sup.1; X.sup.41, X.sup.42 are independently selected from X.sup.1; X.sup.5 is a linear or branched Ci to C10 alkyl; X.sup.6 is selected from X.sup.1 and a divalent 5 or 6 membered aromatic group; R.sup.1, R.sup.2 are independently selected from a monovalent 5 or 6 membered aromatic N-heterocyclic group comprising one N atom or two N atoms which are separated by at least one C atom, and its derivatives received by N-alkylation with a C.sub.1-C.sub.6-alkyl group, which may be substituted by COOR.sup.12 or SO.sub.2OR.sup.12, and which aromatic N-heterocyclic group may optionally further comprise, under the proviso that X21 is substituted by at least one OH, one S atom; R.sup.3, R.sup.4 are independently selected from a monovalent 5 or 6 membered aliphatic N-heterocyclic group comprising one N atom and one O atom; D.sup.1 is independently selected from S, O and NR.sup.10; D.sup.2 is (a) a divalent 5 or 6 membered aliphatic heterocyclic ring system comprising 1 or 2 S atoms, or (b) a 5 or 6 membered aromatic heterocyclic ring system comprising at least two N atoms and optionally one or two S atoms; D.sup.3 is independently selected from S and NR.sup.10; n is an integer of from 0 to 5; z is an integer from 1 to 50; R.sup.10 is selected from H and a linear or branched C.sub.1-C.sub.12 alkyl; R.sup.11 is selected from H and a linear or branched C.sub.1 to C.sub.6 alkyl; and R.sup.12 is selected from R10 and a cation.

2-(phenylalkyloxyalkyl)pyridine derivative or a 2-(phenylalkylthioalkyl)pyridine derivative imparts, when added to food and drink or cosmetics as an active ingredient, a flavor of natural impression thereto; and in particular, when added to food and drink, the compound imparts an umami imparting or enhancing, a saltiness enhancing a sweetness enhancing, and in particular, when added to a milk or dairy product, a food or drink product containing a milk or dairy product, or a dairy replacement product, the compound provides a milk richness enhancing.

2-(phenylalkyloxyalkyl)pyridine derivative or a 2-(phenylalkylthioalkyl)pyridine derivative imparts, when added to food and drink or cosmetics as an active ingredient, a flavor of natural impression thereto; and in particular, when added to food and drink, the compound imparts an umami imparting or enhancing, a saltiness enhancing a sweetness enhancing, and in particular, when added to a milk or dairy product, a food or drink product containing a milk or dairy product, or a dairy replacement product, the compound provides a milk richness enhancing.

2-(phenylalkyloxyalkyl)pyridine derivative or a 2-(phenylalkylthioalkyl)pyridine derivative imparts, when added to food and drink or cosmetics as an active ingredient, a flavor of natural impression thereto; and in particular, when added to food and drink, the compound imparts an umami imparting or enhancing, a saltiness enhancing a sweetness enhancing, and in particular, when added to a milk or dairy product, a food or drink product containing a milk or dairy product, or a dairy replacement product, the compound provides a milk richness enhancing.