Patent classifications
C07D213/73
MANUFACTURING PROCESS FOR AMIFAMPRIDINE PHOSPHATE
The present invention relates to a crystalline form of amifampridine phosphate having an irregular or plate-like, not needle-like crystal habit and to a process for its manufacture.
MANUFACTURING PROCESS FOR AMIFAMPRIDINE PHOSPHATE
The present invention relates to a crystalline form of amifampridine phosphate having an irregular or plate-like, not needle-like crystal habit and to a process for its manufacture.
METHOD AND COMPOUND USEFUL IN PREPARATION OF OREXIN-2 RECEPTOR ANTAGONIST, AND LEMBOREXANT HAVING FEW IMPURITIES
The present application discloses a method and a compound that are useful for preparation of a compound of Formula (XI). Furthermore, the present application discloses the compound of Formula (XI) comprising a small amount of impurities.
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INERT NANOCAPSULES
Compounds are presented having the formula [M.sub.4L.sub.6].X.sub.n, where M is a transition metal ion having 6 d-shell valence electrons, X is a counter ion and n is the number of counterions such that the total charge of the compound of formula (I) is zero, and wherein L is a 5-(5-bipyridin-2,2′-yl)-2,2′-bipyridine or derivative thereof. Methods of preparing the compounds and uses of the compounds to retain radiolabels are also presented.
INERT NANOCAPSULES
Compounds are presented having the formula [M.sub.4L.sub.6].X.sub.n, where M is a transition metal ion having 6 d-shell valence electrons, X is a counter ion and n is the number of counterions such that the total charge of the compound of formula (I) is zero, and wherein L is a 5-(5-bipyridin-2,2′-yl)-2,2′-bipyridine or derivative thereof. Methods of preparing the compounds and uses of the compounds to retain radiolabels are also presented.
COMPOUNDS FOR THE TREATMENT OF ONCOVIRUS INDUCED CANCER AND METHODS OF USE THEREOF
The present invention relates to new inhibitors of Notch signalling pathway and its use in the treatment and/or prevention of cancers.
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COMPOUNDS FOR THE TREATMENT OF ONCOVIRUS INDUCED CANCER AND METHODS OF USE THEREOF
The present invention relates to new inhibitors of Notch signalling pathway and its use in the treatment and/or prevention of cancers.
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SYNTHESIS OF 4-AMINO-5-METHYL-1H-PYRIDIN-2(1H)-ON (INTERMEDIATE COMPOUND FOR THE SYNTHESIS OF THE MR ANTAGONIST FINERENONE) FROM 2-CHLORO-5-METHYL-4-NITRO-PYRIDINE-1-OXIDE USING THE INTERMEDIATE COMPOUND 2-CHLORO-5-METHYL-4-PYRIDINAMINE
The present invention relates to a novel and improved method for preparing 4-amino-5-methylpyridone of the formula (I)
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which is an intermediate in the preparation of the MR antagonist finerenone.
SYNTHESIS OF 4-AMINO-5-METHYL-1H-PYRIDIN-2(1H)-ON (INTERMEDIATE COMPOUND FOR THE SYNTHESIS OF THE MR ANTAGONIST FINERENONE) FROM 2-CHLORO-5-METHYL-4-NITRO-PYRIDINE-1-OXIDE USING THE INTERMEDIATE COMPOUND 2-CHLORO-5-METHYL-4-PYRIDINAMINE
The present invention relates to a novel and improved method for preparing 4-amino-5-methylpyridone of the formula (I)
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which is an intermediate in the preparation of the MR antagonist finerenone.
PROCESS FOR PREPARING 4-AMINO-5-METHYLPYRIDONE
The present invention provides a method for preparing the process intermediate 4-amino-5-methylpyridone of the formula (I), characterized in that the intermediate 4-hydroxy-5-methyl-1H-pyridin-2-one of the formula (III) is reacted with ammonia in an autoclave with addition of an ammonium bromide salt.