Patent classifications
C07D231/20
Processes for making modulators of cystic fibrosis transmembrane conductance regulator
The disclosure provides processes for preparing a compound of Formula (I). ##STR00001##
Compounds useful as modulators of TRPM8
The present invention includes compounds useful as modulators of TRPM8, such as compounds of Formulae (Ia), (Ib) and (Ic), and the subgenus and species thereof; personal products containing those compounds; and the use of those compounds and the personal products, particularly the use of increasing or inducing chemesthetic sensations, such as cooling or cold sensations. ##STR00001##
Compounds useful as modulators of TRPM8
The present invention includes compounds useful as modulators of TRPM8, such as compounds of Formulae (Ia), (Ib) and (Ic), and the subgenus and species thereof; personal products containing those compounds; and the use of those compounds and the personal products, particularly the use of increasing or inducing chemesthetic sensations, such as cooling or cold sensations. ##STR00001##
5-membered and bicyclic heterocyclic amides as inhibitors of ROCK
The present invention provides compounds of Formula (I): ##STR00001##
or stereoisomers, tautomers, or pharmaceutically-acceptable salts thereof, wherein all the variables are as defined herein. These compounds are selective ROCK inhibitors. This invention also relates to pharmaceutical compositions comprising these compounds and methods of treating cardiovascular, smooth muscle, oncologic, neuropathologic, autoimmune, fibrotic, and/or inflammatory disorders using the same.
Tetrazolinone compounds and their use as pesticides
The present invention provides a compound having an excellent efficacy for controlling pests. A tetrazolinone compound of a formula (1) [wherein Q represents a group selected from the following group: Q1, Q2, Q3 or Q4: R.sup.1, R.sup.2, R.sup.3 and R.sup.11 represent independently of each other a halogen atom, an CI-C6 alkyl group, etc.; R.sup.4 and R.sup.5 represent independently of each other a hydrogen atom, a halogen atom or an C1-C3 alkyl group, etc.; R.sup.6 represents a halogen atom, an C1-C4 alkyl group, etc.; R.sup.7, R.sup.8 and R.sup.9 represent independently of each other a hydrogen atom, a halogen atom, etc.; and R.sup.10 represents an C1-C3 alkyl group, etc.] shows an excellent controlling efficacy on pests. ##STR00001##
Tetrazolinone compounds and their use as pesticides
The present invention provides a compound having an excellent efficacy for controlling pests. A tetrazolinone compound of a formula (1) [wherein Q represents a group selected from the following group: Q1, Q2, Q3 or Q4: R.sup.1, R.sup.2, R.sup.3 and R.sup.11 represent independently of each other a halogen atom, an CI-C6 alkyl group, etc.; R.sup.4 and R.sup.5 represent independently of each other a hydrogen atom, a halogen atom or an C1-C3 alkyl group, etc.; R.sup.6 represents a halogen atom, an C1-C4 alkyl group, etc.; R.sup.7, R.sup.8 and R.sup.9 represent independently of each other a hydrogen atom, a halogen atom, etc.; and R.sup.10 represents an C1-C3 alkyl group, etc.] shows an excellent controlling efficacy on pests. ##STR00001##
IMIDAZOLE 3-OXIDE DERIVATIVE BASED ACSS2 INHIBITORS AND METHODS OF USE THEREOF
The present invention relates to novel ACSS2 inhibitors having activity as anti-cancer therapy, treatment of alcoholism, and viral infection (e.g., CMV), composition and methods of preparation thereof, and uses thereof for treating viral infection, alcoholism, alcoholic steatohepatitis (ASH), non-alcoholic steatohepatitis (NASH), obesity/weight gain, anxiety, depression, post-traumatic stress disorder, inflammatory/autoimmune conditions and cancer, including metastatic cancer, advanced cancer, and drug resistant cancer of various types.
AMIDE COMPOUND CONTAINING SUBSTITUTED ACETOPHENONE STRUCTURAL FRAGMENTS AND PREPARATION METHOD AND APPLICATION THEREOF
The present invention discloses an amide compound containing substituted acetophenone structural fragments, having a structure shown by general formula I:
##STR00001##
The definitions of substituents in the formula are shown in the description. The compound of the present invention has broad-spectrum fungal activity, and has excellent control effects on cucumber downy mildew, wheat powdery mildew, corn rust, cucumber anthracnose, cucumber botrytis and tomato botrytis.
ARYL OR HETEROARYL DERIVATIVE
A compound indicated by formula (I) or a pharmacologically acceptable salt thereof is provided as a compound that can be a therapeutic or prophylactic drug for TRPC6-related diseases, such as nephrotic syndrome, membranous nephropathy, acute renal failure, septicemia, chronic renal failure, diabetic nephropathy, pulmonary hypertension, acute lung injury, heart failure, malignant tumor, and muscular dystrophy. (In the formula, Ar.sup.1, Ar.sup.2, X.sup.1-X.sup.3, R.sup.1, R.sup.3, R.sup.7, R.sup.8, L.sup.1, and L.sup.2 are as defined in the specifications.)
##STR00001##
ARYL OR HETEROARYL DERIVATIVE
A compound indicated by formula (I) or a pharmacologically acceptable salt thereof is provided as a compound that can be a therapeutic or prophylactic drug for TRPC6-related diseases, such as nephrotic syndrome, membranous nephropathy, acute renal failure, septicemia, chronic renal failure, diabetic nephropathy, pulmonary hypertension, acute lung injury, heart failure, malignant tumor, and muscular dystrophy. (In the formula, Ar.sup.1, Ar.sup.2, X.sup.1-X.sup.3, R.sup.1, R.sup.3, R.sup.7, R.sup.8, L.sup.1, and L.sup.2 are as defined in the specifications.)
##STR00001##