Described herein, inter alia, are compositions and methods for modulating mu opioid receptor activity.

Phenyl cyclohexanone based active agents, pharmaceutical preparations containing such active agents, methods of modifying cellular activity by contacting cells with such active agents, and methods of treating various conditions by administering such active agents to a patient are described.

Zwitterionic surfactant compounds and their use in connection with absorbent paper manufacture in debonder and softener formulations. An exemplary surfactant is an imidazolinium compound of formula:

##STR00001##

wherein X is SO.sub.3, R.sup.1 is a hydrocarbyl spacer group having a chain length of from 2-6 carbon atoms, R.sup.2 is a hydrocarbyl group having from 8 to 22 carbon atoms; and R.sup.3 is an alkenylamidoalkyl moiety having from 8 to 30 carbon atoms.

Zwitterionic surfactant compounds and their use in connection with absorbent paper manufacture in debonder and softener formulations. An exemplary surfactant is an imidazolinium compound of formula:

##STR00001##

wherein X is SO.sub.3, R.sup.1 is a hydrocarbyl spacer group having a chain length of from 2-6 carbon atoms, R.sup.2 is a hydrocarbyl group having from 8 to 22 carbon atoms; and R.sup.3 is an alkenylamidoalkyl moiety having from 8 to 30 carbon atoms.

Described herein, inter alia, are compositions and methods for modulating mu opioid receptor activity.

Described herein, inter alia, are compositions and methods for modulating mu opioid receptor activity.

Zwitterionic surfactant compounds and their use in connection with absorbent paper manufacture in debonder and softener formulations. An exemplary surfactant is an imidazolinium compound of formula: ##STR00001##
wherein X is SO.sub.3, R.sup.1 is a hydrocarbyl spacer group having a chain length of from 2-6 carbon atoms, R.sup.2 is a hydrocarbyl group having from 8 to 22 carbon atoms; and R.sup.3 is an alkenylamidoalkyl moiety having from 8 to 30 carbon atoms.

Zwitterionic surfactant compounds and their use in connection with absorbent paper manufacture in debonder and softener formulations. An exemplary surfactant is an imidazolinium compound of formula: ##STR00001##
wherein X is SO.sub.3, R.sup.1 is a hydrocarbyl spacer group having a chain length of from 2-6 carbon atoms, R.sup.2 is a hydrocarbyl group having from 8 to 22 carbon atoms; and R.sup.3 is an alkenylamidoalkyl moiety having from 8 to 30 carbon atoms.

Absorbent sheet is manufactured utilizing a low charge density debonder composition comprising an imidazolinium surfactant-containing constituent selected from the group consisting of: (i) cationic imidazolinium surfactants with alkylalkenylhydroxy substitution; (ii) zwitterionic imidazolinium surfactants; and (iii) an ion paired surfactant mixture including a zwitterionic imidazolinium surfactant and a cationic surfactant and, in admixture with the imidazolinium surfactant-containing constituent, (iv) a nonionic surfactant.

Absorbent sheet is manufactured utilizing a low charge density debonder composition comprising an imidazolinium surfactant-containing constituent selected from the group consisting of: (i) cationic imidazolinium surfactants with alkylalkenylhydroxy substitution; (ii) zwitterionic imidazolinium surfactants; and (iii) an ion paired surfactant mixture including a zwitterionic imidazolinium surfactant and a cationic surfactant and, in admixture with the imidazolinium surfactant-containing constituent, (iv) a nonionic surfactant.