A stent configured to change in length while maintaining a constant inner diameter is disclosed. The stent includes an elongated tubular member comprising at least one knitted filament forming a plurality of twisted knit stitches with rungs extending circumferentially between adjacent twisted knit stitches, wherein each twisted knit stitch is interconnected with a longitudinally adjacent twisted knit stitch forming a series of linked stitches. The tubular member is configured to be stretched from a first length to a second length while in a radially expanded configuration without substantially changing the inner and/or outer diameter of the tubular member.

A luminal endoprosthesis assembly (1) at least partially delimits a prosthesis lumen (2), for implantation in an anatomical structure (3) that at least partially defines at least one cavity (4) and includes at least one pathological portion (13). The luminal endoprosthesis (1) has two or more layers (5, 6, 7). At least one layer (5, 6, 7) includes a threadlike element (8) forming an armor (9). The luminal endoprosthesis (1) includes an anchoring portion (10) for anchoring to an anatomical portion (11) of the walls of the cavity (4) of the anatomical structure (3), and a working portion (12) for facing the pathological portion (13) of the anatomical structure (3). The two or more layers (5, 6, 7) are separated from each other in the working portion (12) of the luminal endoprosthesis (1), avoiding connecting elements between one layer (5, 6, 7) and at least one adjacent layer.

A luminal endoprosthesis assembly (1) at least partially delimits a prosthesis lumen (2), for implantation in an anatomical structure (3) that at least partially defines at least one cavity (4) and includes at least one pathological portion (13). The luminal endoprosthesis (1) has two or more layers (5, 6, 7). At least one layer (5, 6, 7) includes a threadlike element (8) forming an armor (9). The luminal endoprosthesis (1) includes an anchoring portion (10) for anchoring to an anatomical portion (11) of the walls of the cavity (4) of the anatomical structure (3), and a working portion (12) for facing the pathological portion (13) of the anatomical structure (3). The two or more layers (5, 6, 7) are separated from each other in the working portion (12) of the luminal endoprosthesis (1), avoiding connecting elements between one layer (5, 6, 7) and at least one adjacent layer.

A device comprising: a tubular anchoring element configured and dimensioned for implanting about a multifurcation zone of a body lumen dividing a main vessel into at least two branches, to anchor the device therein; a removable sleeve defined by a tubular sidewall, the removable sleeve e being dimensioned for being removably received within a lumen of the anchoring element and extending therein at least the multifurcation zone, wherein the removable sleeve is self-expandable from a radially compressed state defining a delivery configuration into the anchoring element, to a radially expanded state defining a fully expanded configuration, wherein at least a portion of the sidewall, the portion encompassing at least inlets of the at least two branches, comprises a mesh having a mesh size sufficient to allow passage of blood and to deflect the flow of embolic material exceeding a predetermined size.

A device comprising: a tubular anchoring element configured and dimensioned for implanting about a multifurcation zone of a body lumen dividing a main vessel into at least two branches, to anchor the device therein; a removable sleeve defined by a tubular sidewall, the removable sleeve e being dimensioned for being removably received within a lumen of the anchoring element and extending therein at least the multifurcation zone, wherein the removable sleeve is self-expandable from a radially compressed state defining a delivery configuration into the anchoring element, to a radially expanded state defining a fully expanded configuration, wherein at least a portion of the sidewall, the portion encompassing at least inlets of the at least two branches, comprises a mesh having a mesh size sufficient to allow passage of blood and to deflect the flow of embolic material exceeding a predetermined size.

Disclosed are a stent delivery and release device and a stent delivery and release system. The stent delivery and release device (20) includes a stent proximal end release assembly provided at a proximal end of the stent delivery and release device, a guide head provided at a distal end of the stent delivery and release device, and a control member, wherein an external stent is configured to be loaded between the guide head and the stent proximal end release assembly; a proximal end of the control member is connected to the stent proximal end release assembly, and at least part of a distal end of the control member is wound around the stent and is detachably connected to the guide head; and the stent proximal end release assembly folds or releases the stent by controlling the axial length of the control member.

Disclosed are a stent delivery and release device and a stent delivery and release system. The stent delivery and release device (20) includes a stent proximal end release assembly provided at a proximal end of the stent delivery and release device, a guide head provided at a distal end of the stent delivery and release device, and a control member, wherein an external stent is configured to be loaded between the guide head and the stent proximal end release assembly; a proximal end of the control member is connected to the stent proximal end release assembly, and at least part of a distal end of the control member is wound around the stent and is detachably connected to the guide head; and the stent proximal end release assembly folds or releases the stent by controlling the axial length of the control member.

Delivery systems for expandable elements, such as stents or scaffolds having spikes, flails, or other protruding features for penetrating target tissue and/or delivering drugs within a human patient are described along with associated methods for using such systems. The delivery systems can be provided with a stent that is positioned over an inflatable balloon for expansion and delivery of the stent to a target delivery location. By positioning the stent over and about the inflatable balloon, the stent is ready to be expanded by the balloon immediately upon unsheathing with respect to the outer shaft. Additionally or alternatively, a stent can be positioned in an axially offset arrangement with respect to a balloon to reduce the need for space required by overlapping components.

A method for implanting a prosthesis centrally within a curved lumen includes loading a prosthesis into a delivery sheath, advancing the sheath in a patient towards the curved lumen to place at least the proximal end of the prosthesis within the curved lumen, and centering the proximal end of the prosthesis and/or the distal end of the sheath within the curved lumen. In a first advancing step, the outer catheter containing the inner sheath is advanced together towards the curved lumen to a location proximal of the curved lumen and, in a second advancing step, the inner sheath containing the prosthesis is advanced into the curved lumen to place at least the proximal end within the curved lumen while the outer catheter substantially remains at the location. After centering, the proximal end of the prosthesis is deployed centered within the curved lumen.

A transcatheter atrio-ventricular valve prosthesis for functional replacement of an atrio-ventricular heart valve in a connection channel, the prosthesis comprising a radially expandable tubular body extending along an axis, and a valve arranged within and attached to the tubular body. The tubular body is provided with an outer circumferential groove which is open to the radial outside of the tubular body, whereby the tubular body is separated by the outer circumferential groove into first and second body sections. The tubular body is provided with a first plurality of projections which extend from the first or second body section in an axial direction of the tubular body and each of which has a free end arranged to overlap the outer circumferential groove. An elongate outer member may be disposed at the exterior of the connection channel wall structure at a level of the circumferential groove.