Provided herein are compounds, compositions, and methods useful for modulating the integrated stress response (ISR) and for treating related diseases; disorders and conditions.

The present invention belongs to the technical field of pesticides, and in particular relates to a pyridazinol compound, a derivative thereof, a preparation method therefor, a herbicidal composition and the use thereof. The pyridazinol compound is as represented by general formula I,

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wherein X represents

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and the ring is an unsubstituted or substituted aryl or unsubstituted or substituted heterocyclyl containing a carbon atom at the 1-position; Y represents haloalkyl; and Z represents halogen, cyano, hydroxy, etc. The derivative refers to an agriculturally acceptable derivative of the hydroxyl group at the 4-position of the pyridazine ring in the general formula I, including a salt, an ester, an oxime, a hydroxylamine and an ether derivative, etc. The compound, the derivative thereof and the composition thereof have good herbicidal activity and crop safety.

Disclosed are compounds of Formula (1) including all geometric and stereoisomers, N-oxides, and salts thereof, wherein W, R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5 m, n and p are as defined in the disclosure. Also disclosed are compositions containing the compounds of Formula (1) and methods for controlling plant disease caused by a fungal pathogen comprising applying an effective amount of a compound or a composition of the invention.

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Disclosed are compounds of Formula (1) including all geometric and stereoisomers, N-oxides, and salts thereof, wherein W, R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5 m, n and p are as defined in the disclosure. Also disclosed are compositions containing the compounds of Formula (1) and methods for controlling plant disease caused by a fungal pathogen comprising applying an effective amount of a compound or a composition of the invention.

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The present invention provides a method for the synthesis of an injectable composition comprising a [.sup.18F]-labelled pyridaben derivative that is advantageous over prior methods. In particular, the method of the present invention comprises a method of radiosynthesis that permits a more facile purification using solid phase extraction (SPE).

The present invention provides a method for the synthesis of an injectable composition comprising a [.sup.18F]-labelled pyridaben derivative that is advantageous over prior methods. In particular, the method of the present invention comprises a method of radiosynthesis that permits a more facile purification using solid phase extraction (SPE).

The present invention relates to esters of carboxylic acid agrochemicals comprising a labile protecting group and having formula (I). Certain of the esters of carboxylic acid agrochemicals do not undergo hydrolysis to a significant degree in the dark, but are cleaved to regenerate the parent carboxylic acid agrochemical when exposed to light. Others of the esters of carboxylic acid agrochemicals undergo hydrolysis under both light and dark conditions. The present invention further relates to methods for the controlled release of a carboxylic acid agrochemicals, and to methods of controlling unwanted plants comprising applying to the unwanted plants an ester of a carboxylic acid agrochemical.

The present invention relates to esters of carboxylic acid agrochemicals comprising a labile protecting group and having formula (I). Certain of the esters of carboxylic acid agrochemicals do not undergo hydrolysis to a significant degree in the dark, but are cleaved to regenerate the parent carboxylic acid agrochemical when exposed to light. Others of the esters of carboxylic acid agrochemicals undergo hydrolysis under both light and dark conditions. The present invention further relates to methods for the controlled release of a carboxylic acid agrochemicals, and to methods of controlling unwanted plants comprising applying to the unwanted plants an ester of a carboxylic acid agrochemical.

The present invention relates to compounds represented by formula (I) (in the formula, R.sup.1 represents, e.g., a substituted or unsubstituted C1-6 alkyl group, R.sup.2 represents a group represented by R.sup.a—CO—O—CR.sup.b.sub.2— or a group represented by R.sup.aO—CO—O—CR.sup.b.sub.2—, each R.sup.a independently represents a substituted or unsubstituted C1-6 alkyl group, each R.sup.b independently represents a hydrogen atom or a substituted or unsubstituted C1-6 alkyl group, R.sup.3 represents, e.g., a hydrogen atom, and Q represents, e.g., a substituted or unsubstituted phenyl group), or salts thereof, and herbicides comprising at least one selected therefrom as an effective component.

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The present invention relates to compounds represented by formula (I) (in the formula, R.sup.1 represents, e.g., a substituted or unsubstituted C1-6 alkyl group, R.sup.2 represents a group represented by R.sup.a—CO—O—CR.sup.b.sub.2— or a group represented by R.sup.aO—CO—O—CR.sup.b.sub.2—, each R.sup.a independently represents a substituted or unsubstituted C1-6 alkyl group, each R.sup.b independently represents a hydrogen atom or a substituted or unsubstituted C1-6 alkyl group, R.sup.3 represents, e.g., a hydrogen atom, and Q represents, e.g., a substituted or unsubstituted phenyl group), or salts thereof, and herbicides comprising at least one selected therefrom as an effective component.

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