Patent classifications
C07D239/14
Anti-alphavbeta1 integrin inhibitors and methods of use
Provided herein, inter alia, are methods and compositions for inhibiting v1 integrin and for treating fibrosis.
Anti-alphavbeta1 integrin inhibitors and methods of use
Provided herein, inter alia, are methods and compositions for inhibiting v1 integrin and for treating fibrosis.
META-AZACYCLIC AMINO BENZOIC ACID DERIVATIVES AS PAN INTEGRIN ANTAGONISTS
The present disclosure provides pharmaceutical agents of the formula:
##STR00001##
wherein the variables are defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such pharmaceutical agents. Methods of using the pharmaceutical agents for the treatment of a variety of diseases and disorders are also provided.
META-AZACYCLIC AMINO BENZOIC ACID DERIVATIVES AS PAN INTEGRIN ANTAGONISTS
The present disclosure provides pharmaceutical agents of the formula:
##STR00001##
wherein the variables are defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such pharmaceutical agents. Methods of using the pharmaceutical agents for the treatment of a variety of diseases and disorders are also provided.
SYNTHESIS OF CYCLOCREATINE AND ANALOGS THEREOF
Provided herein is a process and intermediates for the preparation of a compound of formula (I): or a pharmaceutically acceptable salt thereof, using cyanamide in the reaction.
##STR00001##
SYNTHESIS OF CYCLOCREATINE AND ANALOGS THEREOF
Provided herein is a process and intermediates for the preparation of a compound of formula (I): or a pharmaceutically acceptable salt thereof, using cyanamide in the reaction.
##STR00001##
TETRALIN AND INDANE DERIVATIVES AND USES THEREOF
The applicaton discloses pharmaceutical compounds of formula I useful for treating CNS diseases wherein m, s, R.sup.1R.sup.5, R.sup.6 and R.sup.7 are as defined herein.
##STR00001##
TETRALIN AND INDANE DERIVATIVES AND USES THEREOF
The applicaton discloses pharmaceutical compounds of formula I useful for treating CNS diseases wherein m, s, R.sup.1R.sup.5, R.sup.6 and R.sup.7 are as defined herein.
##STR00001##
Synthesis of cyclocreatine and analogs thereof
Provided herein is a process and intermediates for the preparation of a compound of formula (I): ##STR00001##
or a pharmaceutically acceptable salt thereof, using cyanamide in the reaction.
Synthesis of cyclocreatine and analogs thereof
Provided herein is a process and intermediates for the preparation of a compound of formula (I): ##STR00001##
or a pharmaceutically acceptable salt thereof, using cyanamide in the reaction.