Patent classifications
C07D239/14
Tetralin and indane derivatives and uses thereof
Compounds of the formula I: ##STR00001##
or pharmaceutically acceptable salts thereof,
wherein m, p, q, Ar, R.sup.1 and R.sup.2 are as defined herein. Also provided are methods for preparing, compositions comprising, and methods for using compounds of formula I.
Integrin antagonist conjugates for targeted delivery to cells expressing alpha-V-beta-3
The invention relates to compounds of formula (I): wherein R.sup.1, R.sup.2, and n are defined in the detailed description and claims. In particular, the present invention relates to the compounds of formula (I) for use in the manufacture and delivery of conjugated moieties such as small molecules, peptides, nucleic acids, fluorescent moieties, and polymers which are linked to alpha-V-beta-3 integrin antagonists to target cells expressing alpha-V-beta-3. ##STR00001##
Integrin antagonist conjugates for targeted delivery to cells expressing alpha-V-beta-3
The invention relates to compounds of formula (I): wherein R.sup.1, R.sup.2, and n are defined in the detailed description and claims. In particular, the present invention relates to the compounds of formula (I) for use in the manufacture and delivery of conjugated moieties such as small molecules, peptides, nucleic acids, fluorescent moieties, and polymers which are linked to alpha-V-beta-3 integrin antagonists to target cells expressing alpha-V-beta-3. ##STR00001##
INHIBITORS OF CREATINE TRANSPORT AND USES THEREOF
This invention relates to compounds that inhibit creatine transport and/or creatine kinase, pharmaceutical compositions including such compounds, and methods of utilizing such compounds and compositions for the treatment of cancer.
INHIBITORS OF CREATINE TRANSPORT AND USES THEREOF
This invention relates to compounds that inhibit creatine transport and/or creatine kinase, pharmaceutical compositions including such compounds, and methods of utilizing such compounds and compositions for the treatment of cancer.
Aryl hydrocarbon receptor agonists and uses thereof
The present invention relates to pharmaceutical compounds of Formula (I): ##STR00001##
as further described herein, and pharmaceutical compositions containing such compounds, as well as methods of using these compounds to modulate the activity of aryl hydrocarbon receptor (AhR) and to treat conditions comprising inflammation inside the intestinal tract and certain disorders of the central nervous system affected by the gut-brain axis, including IBD, ulcerative colitis, Crohn's disease, Huntington's disease, and multiple sclerosis.