Patent classifications
C
CHEMISTRY; METALLURGY
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C07
ORGANIC CHEMISTRY
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C07D
HETEROCYCLIC COMPOUNDS
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239/00
Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
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C07D239/70
condensed with carbocyclic rings or ring systems
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C07D239/72
Quinazolines; Hydrogenated quinazolines
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C07D239/78
with hetero atoms directly attached in position 2
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C07D239/82
with an aryl radical attached in position 4
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C07D239/82

Substituted pyrrolo[3,4-b]pyridines as PI3K-α inhibitors
12581252 · 2026-03-17 · ·

The present disclosure relates to novel compounds and pharmaceutical compositions thereof, and methods for inhibiting the activity of PI3K enzymes with the compounds and compositions of formula I-1. The present disclosure further relates to, but is not limited to, methods for treating disorders associated with PI3K signaling with the compounds and compositions of formula I-1. ##STR00001##