Disclosed are compounds inhibiting ErbBs (e.g., EGFR or Her 2), especially mutant forms of ErbBs, and BTK, pharmaceutically acceptable salts, hydrates, solvates or stereoisomers thereof and pharmaceutical compositions comprising the compounds. The compound and the pharmaceutical composition can effectively treat ErbBs (especially mutant forms of ErbBs) or BTK associated diseases, including cancer.

The disclosure relates to aryl hydrocarbon receptor antagonists as well as methods of modulating aryl hydrocarbon receptor activity and expanding hematopoietic stem cells by culturing hematopoietic stem or progenitor cells in the presence of these agents. Additionally, the disclosure provides methods of treating various pathologies, such as cancer, by administration of these aryl hydrocarbon receptor antagonists. Additionally, the disclosure provides methods of treating various pathologies in a patient by administration of expanded hematopoietic stem cells. The disclosure further provides kits containing aryl hydrocarbon receptor antagonists that can be used for the expansion of hematopoietic stem cells. The disclosure further relates to pharmaceutical compositions comprising the compounds and methods of treating or preventing a disease in which aryl hydrocarbon receptor plays a role.

Compounds of formula (I) or a pharmaceutically acceptable salt thereof, and/or solvates, racemic mixtures, enantiomers, diasteromers, and tautomers thereof, wherein A, R.sub.1, R.sub.2, R.sub.3, R.sub.3′, R.sub.4, R.sub.4′, R.sub.5, R.sub.6, R.sub.7, R.sub.8, m, and n are as defined in the detailed description.

##STR00001##

Compounds of formula (I) or a pharmaceutically acceptable salt thereof, and/or solvates, racemic mixtures, enantiomers, diasteromers, and tautomers thereof, wherein A, R.sub.1, R.sub.2, R.sub.3, R.sub.3′, R.sub.4, R.sub.4′, R.sub.5, R.sub.6, R.sub.7, R.sub.8, m, and n are as defined in the detailed description.

##STR00001##

Provided are compounds useful for treating cancer and methods of treating cancer comprising administering to a subject in need thereof a compound described herein.

Provided are compounds useful for treating cancer and methods of treating cancer comprising administering to a subject in need thereof a compound described herein.

The present invention relates to diaminotriazine compounds of the formula (I) and to their use as herbicides. The present invention also relates to agrochemical compositions for crop protection and to a method for controlling unwanted vegetation. ##STR00001## wherein q is 0, 1, 2 or 3 R.sup.a is selected from the group consisting of C.sub.1-C.sub.6-haloalkoxy, C.sub.1-C.sub.6-haloalkylthio, (C.sub.1-C.sub.6-haloalkyl)sulfinyl, (C.sub.1-C.sub.6-haloalkyl)-carbonyl, etc.; R.sup.b is selected from the group consisting of halogen, OH, CN, amino, NO.sub.2, C.sub.1-C.sub.6-alkyl, C.sub.2-C.sub.6-alkenyl, C.sub.2-C.sub.6-alkynyl, C.sub.1-C.sub.6-alkoxy, etc.; R.sup.1 is selected from the group consisting of H, OH, S(O).sub.2NH.sub.2, CN, C.sub.1-C.sub.6-alkyl, C.sub.2-C.sub.6-alkenyl, C.sub.2-C.sub.6-alkynyl, (C.sub.3-C.sub.6-cycloalkyl)-C.sub.1-C.sub.4-alkyl, etc.; R.sup.2 is selected from the group consisting of H, OH, S(O).sub.2NH.sub.2, CN, C.sub.1-C.sub.6-alkyl, C.sub.2-C.sub.6-alkenyl, C.sub.2-C.sub.6-alkynyl, (C.sub.3-C.sub.6-cycloalkyl)-C.sub.1-C.sub.4-alkyl, etc.; R.sup.3 is selected from the group consisting of H, halogen, OH, CN, C.sub.1-C.sub.6-alkyl, (C.sub.1-C.sub.6-alkoxy)-C.sub.1-C.sub.6-alkyl, C.sub.3-C.sub.6-cycloalkyl, etc.; R.sup.4 is H, halogen, CN, C.sub.1-C.sub.6-alkyl, C.sub.1-C.sub.6-haloalkyl, C.sub.3-C.sub.6-cycloalkyl, C.sub.3-C.sub.6-halocycloalkyl, C.sub.1-C.sub.6-alkoxy and C.sub.1-C.sub.6-haloalkoxy; R.sup.5 is selected from the group consisting of halogen, CN, C.sub.1-C.sub.6-alkyl, C.sub.2-C.sub.6-alkenyl, C.sub.3-C.sub.6-alkynyl, C.sub.3-C.sub.6-cycloalkyl, etc.; or R.sup.4 and R.sup.5 together with the carbon atom to which they are attached form a moiety selected from the group consisting of carbonyl, C.sub.3-C.sub.6-cycloalkan-1,1-diyl, ipso-C.sub.3-C.sub.6-cycloalkendiyl, three- to six-membered saturated or partially unsaturated ipso-heterocyclodiyl; including their agriculturally acceptable salts.

The present invention relates to diaminotriazine compounds of the formula (I) and to their use as herbicides. The present invention also relates to agrochemical compositions for crop protection and to a method for controlling unwanted vegetation. ##STR00001## wherein q is 0, 1, 2 or 3 R.sup.a is selected from the group consisting of C.sub.1-C.sub.6-haloalkoxy, C.sub.1-C.sub.6-haloalkylthio, (C.sub.1-C.sub.6-haloalkyl)sulfinyl, (C.sub.1-C.sub.6-haloalkyl)-carbonyl, etc.; R.sup.b is selected from the group consisting of halogen, OH, CN, amino, NO.sub.2, C.sub.1-C.sub.6-alkyl, C.sub.2-C.sub.6-alkenyl, C.sub.2-C.sub.6-alkynyl, C.sub.1-C.sub.6-alkoxy, etc.; R.sup.1 is selected from the group consisting of H, OH, S(O).sub.2NH.sub.2, CN, C.sub.1-C.sub.6-alkyl, C.sub.2-C.sub.6-alkenyl, C.sub.2-C.sub.6-alkynyl, (C.sub.3-C.sub.6-cycloalkyl)-C.sub.1-C.sub.4-alkyl, etc.; R.sup.2 is selected from the group consisting of H, OH, S(O).sub.2NH.sub.2, CN, C.sub.1-C.sub.6-alkyl, C.sub.2-C.sub.6-alkenyl, C.sub.2-C.sub.6-alkynyl, (C.sub.3-C.sub.6-cycloalkyl)-C.sub.1-C.sub.4-alkyl, etc.; R.sup.3 is selected from the group consisting of H, halogen, OH, CN, C.sub.1-C.sub.6-alkyl, (C.sub.1-C.sub.6-alkoxy)-C.sub.1-C.sub.6-alkyl, C.sub.3-C.sub.6-cycloalkyl, etc.; R.sup.4 is H, halogen, CN, C.sub.1-C.sub.6-alkyl, C.sub.1-C.sub.6-haloalkyl, C.sub.3-C.sub.6-cycloalkyl, C.sub.3-C.sub.6-halocycloalkyl, C.sub.1-C.sub.6-alkoxy and C.sub.1-C.sub.6-haloalkoxy; R.sup.5 is selected from the group consisting of halogen, CN, C.sub.1-C.sub.6-alkyl, C.sub.2-C.sub.6-alkenyl, C.sub.3-C.sub.6-alkynyl, C.sub.3-C.sub.6-cycloalkyl, etc.; or R.sup.4 and R.sup.5 together with the carbon atom to which they are attached form a moiety selected from the group consisting of carbonyl, C.sub.3-C.sub.6-cycloalkan-1,1-diyl, ipso-C.sub.3-C.sub.6-cycloalkendiyl, three- to six-membered saturated or partially unsaturated ipso-heterocyclodiyl; including their agriculturally acceptable salts.

The present invention relates to diaminotriazine compounds of formula (I)

##STR00001##

wherein the variables are defined according to the description,
processes for preparing them, compositions comprising them, their use as herbicides or for the desiccation/defoliation of plants as well as a method for controlling unwanted vegetation.

Disclosed are compounds inhibiting ErbBs (e.g., EGFR or Her 2), especially mutant forms of ErbBs, and BTK, pharmaceutically acceptable salts, hydrates, solvates or stereoisomers thereof and pharmaceutical compositions comprising the compounds. The compound and the pharmaceutical composition can effectively treat ErbBs (especially mutant forms of ErbBs) or BTK associated diseases, including cancer.