A composition-of-matter comprising a crystallized form of a large ribosomal (50S) subunit of a pathogenic bacterium, and the atomic coordinates of the three-dimensional structure thereof are provided herein, as well as methods for crystallizing the same, and using the atomic coordinates of the same to design de novo ligands with high specificity thereto.

The present invention relates to methods for producing particles of metaxalone using dry milling processes as well as compositions comprising metaxalone, medicaments produced using metaxalone in particulate form and/or compositions, and to methods of treatment of an animal, including man, using a therapeutically effective amount of metaxalone administered by way of said medicaments.

The present invention relates to methods for producing particles of metaxalone using dry milling processes as well as compositions comprising metaxalone, medicaments produced using metaxalone in particulate form and/or compositions, and to methods of treatment of an animal, including man, using a therapeutically effective amount of metaxalone administered by way of said medicaments.

The present invention relates to oxazolidinone Compounds of Formula (I): (I) and pharmaceutically acceptable salts thereof, wherein A, E, and R1 are as defined herein. The present invention also relates to compositions which comprise at least one oxazolidinone compound of the invention. The invention also provides methods for inhibiting growth of mycobacterial cells as well as a method of treating mycobacterial infections by Mycobacterium tuberculosis comprising administering a therapeutically effective amount of an oxazolidinone of the invention and/or a pharmaceutically acceptable salt thereof, or a composition comprising such compound and/or salt. ##STR00001##

The present invention relates to therapeutic combinations of anti-bacterial agents linezolid, bedaquiline and pretomanid, and optionally with pyrazinamide, in a short-course oral dosage regimen for the treatment of tuberculosis.

The present invention relates to therapeutic combinations of anti-bacterial agents linezolid, bedaquiline and pretomanid, and optionally with pyrazinamide, in a short-course oral dosage regimen for the treatment of tuberculosis.

A composition-of-matter comprising a crystallized form of a large ribosomal (50S) subunit of a pathogenic bacterium, and the atomic coordinates of the three-dimensional structure thereof are provided herein, as well as methods for crystallizing the same, and using the atomic coordinates of the same to design de novo ligands with high specificity thereto.

A composition-of-matter comprising a crystallized form of a large ribosomal (50S) subunit of a pathogenic bacterium, and the atomic coordinates of the three-dimensional structure thereof are provided herein, as well as methods for crystallizing the same, and using the atomic coordinates of the same to design de novo ligands with high specificity thereto.

A process is provided for preparing ethylene amines of the formula NH.sub.2(C.sub.2H.sub.4NH).sub.pH wherein p is at least 2, or derivatives thereof wherein one or more units NHC.sub.2H.sub.4NH are present as a cyclic ethylene urea unit

##STR00001##

The process includes reacting an ethanolamine-functional compound OH(C.sub.2H.sub.4NH).sub.qH or HO(C.sub.2H.sub.4NH).sub.qC.sub.2H.sub.4OH wherein q is at least 1, and an amine-functional compound NH.sub.2(C.sub.2H.sub.4NH).sub.rH wherein r is at least 1, in the presence of a carbon oxide delivering agent and water, with a molar ratio of water:carbon oxide delivering agent of from about 0.01:1 to about 2:1.

A process is provided for preparing ethylene amines of the formula NH.sub.2(C.sub.2H.sub.4NH).sub.pH wherein p is at least 2, or derivatives thereof wherein one or more units NHC.sub.2H.sub.4NH are present as a cyclic ethylene urea unit

##STR00001##

The process includes reacting an ethanolamine-functional compound OH(C.sub.2H.sub.4NH).sub.qH or HO(C.sub.2H.sub.4NH).sub.qC.sub.2H.sub.4OH wherein q is at least 1, and an amine-functional compound NH.sub.2(C.sub.2H.sub.4NH).sub.rH wherein r is at least 1, in the presence of a carbon oxide delivering agent and water, with a molar ratio of water:carbon oxide delivering agent of from about 0.01:1 to about 2:1.