Patent classifications
C07D263/42
Polyfunctional compounds, methods for preparing same and uses thereof
Disclosed are polyfunctional compounds of formula: ##STR00001##
as well as methods for preparing same and the uses thereof, in particular in orthogonal or bioorthogonal processes.
Polyfunctional compounds, methods for preparing same and uses thereof
Disclosed are polyfunctional compounds of formula: ##STR00001##
as well as methods for preparing same and the uses thereof, in particular in orthogonal or bioorthogonal processes.
TARGETING OXAZOLE STRUCTURES FOR THERAPY AGAINST INFLAMMATORY DISEASES
Described herein are novel compositions, targeted therapeutic methods, and assays for neutralizing and/or inhibiting the activity of oxazole-containing (OxC) compounds, to prevent or delay the onset of epithelial barrier dysfunction and chronic inflammation associated with various disorders, such as colitis.
POLYFUNCTIONAL COMPOUNDS, METHODS FOR PREPARING SAME AND USES THEREOF
Disclosed are polyfunctional compounds of formula:
##STR00001##
as well as methods for preparing same and the uses thereof, in particular in orthogonal or bioorthogonal processes.
POLYFUNCTIONAL COMPOUNDS, METHODS FOR PREPARING SAME AND USES THEREOF
Disclosed are polyfunctional compounds of formula:
##STR00001##
as well as methods for preparing same and the uses thereof, in particular in orthogonal or bioorthogonal processes.
2-ARYL-4-HYDROXY-1,3-THIAZOLE DERIVATIVES USEFUL AS TRPM8-INHIBITORS IN TREATMENT OF NEURALGIA, PAIN, COPD AND ASTHMA
The invention relates to compounds acting as selective antagonists of Transient Receptor Potential cation channel subfamily M member 8 (TRPM8), and having formula (I).
##STR00001##
Said compounds are useful in the treatment of diseases associated with activity of TRPM8 such as pain, inflammation, ischaemia, neurodegeneration, stroke, psychiatric disorders, itch, irritable bowel diseases, cold induced and/or exacerbated respiratory disorders and urological disorders.
2-ARYL-4-HYDROXY-1,3-THIAZOLE DERIVATIVES USEFUL AS TRPM8-INHIBITORS IN TREATMENT OF NEURALGIA, PAIN, COPD AND ASTHMA
The invention relates to compounds acting as selective antagonists of Transient Receptor Potential cation channel subfamily M member 8 (TRPM8), and having formula (I).
##STR00001##
Said compounds are useful in the treatment of diseases associated with activity of TRPM8 such as pain, inflammation, ischaemia, neurodegeneration, stroke, psychiatric disorders, itch, irritable bowel diseases, cold induced and/or exacerbated respiratory disorders and urological disorders.
Monocyclic compound
The present invention relates to a compound which may be useful as an agent for the prophylaxis or treatment of cancer, hepatitis, hepatic fibrosis, fatty liver and the like.
Monocyclic compound
The present invention relates to a compound which may be useful as an agent for the prophylaxis or treatment of cancer, hepatitis, hepatic fibrosis, fatty liver and the like.
Hydrocarbon polymers having two azlactone end groups
1) Hydrocarbon polymer having two azlactone end groups ##STR00001##
F.sup.1 is formula (IIa) and F.sup.2 is formula (IIb): ##STR00002## g and d are 0, 1, 2 or 3; R.sup.14 and R.sup.15 are C.sub.1-C.sub.4 or a cyclohexyl radical; R.sup.1 to R.sup.12 represents hydrogen or alkyl with 1 to 22 carbon atoms; x and y are integers, x+y is 0 to 2; R.sup.13 is oxygen or sulphur or divalent CH.sub.2 n1, n2, m, p1 and p2 are an integer or equal to 0 and such that the molecular weight Mn of the polymer of formula (I) is between 400 and 100 000 g/mol; a process for preparation of the polymer; and use as adhesive in mixture with an amino compound with at least two amine groups.