Patent classifications
C07D263/42
Hydrocarbon polymers having two azlactone end groups
1) Hydrocarbon polymer having two azlactone end groups ##STR00001##
F.sup.1 is formula (IIa) and F.sup.2 is formula (IIb): ##STR00002## g and d are 0, 1, 2 or 3; R.sup.14 and R.sup.15 are C.sub.1-C.sub.4 or a cyclohexyl radical; R.sup.1 to R.sup.12 represents hydrogen or alkyl with 1 to 22 carbon atoms; x and y are integers, x+y is 0 to 2; R.sup.13 is oxygen or sulphur or divalent CH.sub.2 n1, n2, m, p1 and p2 are an integer or equal to 0 and such that the molecular weight Mn of the polymer of formula (I) is between 400 and 100 000 g/mol; a process for preparation of the polymer; and use as adhesive in mixture with an amino compound with at least two amine groups.
MONOCYCLIC COMPOUND
The present invention relates to a compound which may be useful as an agent for the prophylaxis or treatment of cancer, hepatitis, hepatic fibrosis, fatty liver and the like.
MONOCYCLIC COMPOUND
The present invention relates to a compound which may be useful as an agent for the prophylaxis or treatment of cancer, hepatitis, hepatic fibrosis, fatty liver and the like.
Compound having skin-whitening, anti-oxidizing and PPAR activities and medical use thereof
Provided are a novel compound having skin-whitening, anti-oxidizing and PPAR activities and a medical use thereof, and the compound has skin-whitening activities for the suppression of tyrosinase, and accordingly, is useful for use in skin-whitening pharmaceutical composition or cosmetic products; has anti-oxidant activities, and accordingly, is useful for the prevention and treatment of skin-aging; and has PPAR activities, and in particular, PPAR and PPAR activities, and accordingly, is useful for use in pharmaceutical compositions or health foods which are effective for the prevention and treatment of obesity, metabolic disease, or cardiovascular disease.
Compound having skin-whitening, anti-oxidizing and PPAR activities and medical use thereof
Provided are a novel compound having skin-whitening, anti-oxidizing and PPAR activities and a medical use thereof, and the compound has skin-whitening activities for the suppression of tyrosinase, and accordingly, is useful for use in skin-whitening pharmaceutical composition or cosmetic products; has anti-oxidant activities, and accordingly, is useful for the prevention and treatment of skin-aging; and has PPAR activities, and in particular, PPAR and PPAR activities, and accordingly, is useful for use in pharmaceutical compositions or health foods which are effective for the prevention and treatment of obesity, metabolic disease, or cardiovascular disease.
HYDROCARBON POLYMERS HAVING TWO AZLACTONE END GROUPS
F.sup.1 is formula (IIa) and F.sup.2 is formula (IIb):
##STR00001## g and d are 0, 1, 2 or 3; R.sup.14 and R.sup.15 are C.sub.1-C.sub.4 or a cyclohexyl radical; R.sup.1 to R.sup.12 represents hydrogen or alkyl with 1 to 22 carbon atoms; x and y are integers, x+y is 0 to 2; R.sup.13 is oxygen or sulphur or divalent CH.sub.2 n1, n2, m, p1 and p2 are an integer or equal to 0 and such that the molecular weight Mn of the polymer of formula (I) is between 400 and 100 000 g/mol; a process for preparation of the polymer; and use as adhesive in mixture with an amino compound with at least two amine groups.
##STR00002##
HYDROCARBON POLYMERS HAVING TWO AZLACTONE END GROUPS
F.sup.1 is formula (IIa) and F.sup.2 is formula (IIb):
##STR00001## g and d are 0, 1, 2 or 3; R.sup.14 and R.sup.15 are C.sub.1-C.sub.4 or a cyclohexyl radical; R.sup.1 to R.sup.12 represents hydrogen or alkyl with 1 to 22 carbon atoms; x and y are integers, x+y is 0 to 2; R.sup.13 is oxygen or sulphur or divalent CH.sub.2 n1, n2, m, p1 and p2 are an integer or equal to 0 and such that the molecular weight Mn of the polymer of formula (I) is between 400 and 100 000 g/mol; a process for preparation of the polymer; and use as adhesive in mixture with an amino compound with at least two amine groups.
##STR00002##
Host material, composition, and organic electroluminescent element
To improve the emission efficiency, the driving voltage and the lifetime of an organic light-emitting device using a delayed fluorescent material. A host material for a delayed fluorescent material, containing a compound represented by the following general formula: R.sup.1 to R.sup.5 each are a substituent not containing a cyano group, n1 to n5 each are 0 to 4, Ar is a monocyclic arylene group or a monocyclic heteroarylene group. ##STR00001##
TRPM8 antagonists
The invention relates to compounds acting as selective antagonists of Transient Receptor Potential cation channel subfamily M member 8 (TRPM8), and having formula: ##STR00001## Said compounds are useful in the treatment of diseases associated with activity of TRPM8 such as pain, inflammation, ischaemia, neurodegeneration, stroke, psychiatric disorders, itch, irritable bowel diseases, cold induced and/or exacerbated respiratory disorders and urological disorders.
2-ARYL-4-HYDROXY-1,3-THIAZOLE DERIVATIVES USEFUL AS TRPM8-INHIBITORS IN TREATMENT OF NEURALGIA, PAIN, COPD AND ASTHMA
The invention relates to compounds acting as selective antagonists of Transient Receptor Potential cation channel subfamily M member 8 (TRPM8), and having formula (I).
##STR00001##
Said compounds are useful in the treatment of diseases associated with activity of TRPM8 such as pain, inflammation, ischaemia, neurodegeneration, stroke, psychiatric disorders, itch, irritable bowel diseases, cold induced and/or exacerbated respiratory disorders and urological disorders.