The present disclosure relates to compounds of Formula (I) and (II):

##STR00001##

and to their prodrugs, pharmaceutically acceptable salts, pharmaceutical compositions, methods of use, and methods for their preparation. The compounds disclosed herein are useful for modulating H1 and 5-HT.sub.2A receptors and are to be used in the treatment of sleep disorders, such as sleep fragmentation, disturbed sleep/arousals, and arousal threshold.

The present disclosure relates to compounds of Formula (I) and (II):

##STR00001##

and to their prodrugs, pharmaceutically acceptable salts, pharmaceutical compositions, methods of use, and methods for their preparation. The compounds disclosed herein are useful for modulating H1 and 5-HT.sub.2A receptors and are to be used in the treatment of sleep disorders, such as sleep fragmentation, disturbed sleep/arousals, and arousal threshold.

The present invention relates to an OLED, comprising an anode, a cathode and one or more organic layers, and at least one of the organic layers comprising a material having the following chemical formula I or II. Since the compound having the formula (I) in the present invention has electron-withdrawing groups and electron-donating groups with high stability, stable chemical bonds exist between them, without strong conjugation. With these characteristics, the compound having the formula (I) has higher fluorescence quantum efficiency and excellent charge transport ability, and its emission spectra are closer to the international standard of dark blue, to facilitate to the realization of full-color displays with higher color purity.

##STR00001##

The presently described technology provides a novel class of prodrugs of quetiapine that can be synthesized by chemically conjugating amino acids. The present technology also provides methods of treating patients, pharmaceutical compositions and methods of synthesizing conjugates of the present technology.

A genus of arylsulfonamide derivatives of aminocycloalkanols is disclosed. The compounds are of the following genus: ##STR00001##
The compounds induce FOXO1 transcription factor translocation to the nucleus by modulating PP2A and, as a consequence, exhibit anti-proliferative effects. They are useful in the treatment of a variety of disorders, including as a monotherapy in cancer treatment, or used in combination with other drugs to restore sensitivity to chemotherapy where resistance has developed.

A genus of arylsulfonamide derivatives of aminocycloalkanols is disclosed. The compounds are of the following genus: ##STR00001##
The compounds induce FOXO1 transcription factor translocation to the nucleus by modulating PP2A and, as a consequence, exhibit anti-proliferative effects. They are useful in the treatment of a variety of disorders, including as a monotherapy in cancer treatment, or used in combination with other drugs to restore sensitivity to chemotherapy where resistance has developed.

The presently described technology provides a novel class of prodrugs of quetiapine that can be synthesized by chemically conjugating amino acids. The present technology also provides methods of treating patients, pharmaceutical compositions and methods of synthesizing conjugates of the present technology.

The presently described technology provides a novel class of prodrugs of quetiapine that can be synthesized by chemically conjugating amino acids. The present technology also provides methods of treating patients, pharmaceutical compositions and methods of synthesizing conjugates of the present technology.

The presently described technology provides a novel class of prodrugs of quetiapine that can be synthesized by chemically conjugating amino acids, such as Lysine to quetiapine. The present technology also provides methods of treating patients, pharmaceutical compositions and methods of synthesizing conjugates of the present technology.

The presently described technology provides a novel class of prodrugs of quetiapine that can be synthesized by chemically conjugating amino acids to quetiapine. The present technology also provides methods of treating patients, pharmaceutical compositions and methods of synthesizing conjugates of the present technology.