A device comprising: a tubular anchoring element configured and dimensioned for implanting about a multifurcation zone of a body lumen dividing a main vessel into at least two branches, to anchor the device therein; a removable sleeve defined by a tubular sidewall, the removable sleeve e being dimensioned for being removably received within a lumen of the anchoring element and extending therein at least the multifurcation zone, wherein the removable sleeve is self-expandable from a radially compressed state defining a delivery configuration into the anchoring element, to a radially expanded state defining a fully expanded configuration, wherein at least a portion of the sidewall, the portion encompassing at least inlets of the at least two branches, comprises a mesh having a mesh size sufficient to allow passage of blood and to deflect the flow of embolic material exceeding a predetermined size.

Disclosed herein is a bowl-shaped neck bridge with a distal-facing concavity and a central lumen. The neck bridge is inserted and expanded within a cerebral aneurysm. The, embolic members (such as embolic coils, embolic ribbons, or string-of-pearls embolic strands) are inserted through the central lumen into the aneurysm sac.

The acute and chronic devices and methods described herein include a body lumen fluid flow modulator including an upstream flow accelerator and a downstream flow decelerator. The fluid flow modulator preferably includes one or more openings that define a gap/entrainment region that provides a pathway through which additional fluid from a branch lumen(s) is entrained into the fluid stream flowing from the upstream flow accelerator to the downstream flow decelerator. Delivery devices including a sheath and inner assembly also are provided for delivering the flow modulator to the body lumen. The delivery device may maintain the flow modulator in its collapsed, delivery state upon retraction of the sheath for ease of readjustment within the body lumen prior to full deployment of the flow modulator within the body lumen.

The acute and chronic devices and methods described herein include a body lumen fluid flow modulator including an upstream flow accelerator and a downstream flow decelerator. The fluid flow modulator preferably includes one or more openings that define a gap/entrainment region that provides a pathway through which additional fluid from a branch lumen(s) is entrained into the fluid stream flowing from the upstream flow accelerator to the downstream flow decelerator. Delivery devices including a sheath and inner assembly also are provided for delivering the flow modulator to the body lumen. The delivery device may maintain the flow modulator in its collapsed, delivery state upon retraction of the sheath for ease of readjustment within the body lumen prior to full deployment of the flow modulator within the body lumen.

Support frames and medical devices are described. An example medical device comprises an expandable support frame with first and second leaflets attached to the support frame. Each of the first and second leaflets defines a domed radius that is equal to or less than the radius of the expandable support frame when the expandable support frame is in an expanded configuration and the leaflets are subjected to fluid pressure sufficient to affect closure of the valve orifice.

Support frames and medical devices are described. An example medical device comprises an expandable support frame with first and second leaflets attached to the support frame. Each of the first and second leaflets defines a domed radius that is equal to or less than the radius of the expandable support frame when the expandable support frame is in an expanded configuration and the leaflets are subjected to fluid pressure sufficient to affect closure of the valve orifice.

A stent includes a first longitudinally extended cylinder having a C-shaped cross-section and a second longitudinally extended cylinder having a C-shaped cross-section. The first cylinder includes a plurality of first longitudinal struts and an array of first radial struts extending between the first longitudinal struts. The second cylinder includes a plurality of second longitudinal struts and an array of second radial struts extending between the second longitudinal struts. The first cylinder and the second cylinder are configured to form a dense mesh structure when assembled. When assembled, the second cylinder may be disposed in the first cylinder. The first cylinder may overlap with the second cylinder to form the dense mesh structure.

A stent includes a first longitudinally extended cylinder having a C-shaped cross-section and a second longitudinally extended cylinder having a C-shaped cross-section. The first cylinder includes a plurality of first longitudinal struts and an array of first radial struts extending between the first longitudinal struts. The second cylinder includes a plurality of second longitudinal struts and an array of second radial struts extending between the second longitudinal struts. The first cylinder and the second cylinder are configured to form a dense mesh structure when assembled. When assembled, the second cylinder may be disposed in the first cylinder. The first cylinder may overlap with the second cylinder to form the dense mesh structure.

A vascular implant, comprising a sheet comprising thin film nickel titanium (NiTi), wherein the sheet has at least one super-hydrophilic surface having a water contact angle of less than approximately 5 degrees. The sheet is configured to have a compacted form having a first internal diameter and a deployed form having a second internal diameter larger than the first internal diameter. The sheet may be delivered into a blood vessel in the compacted form and expanded to its deployed form at a treatment location within the blood vessel, wherein the stent is configured to expand onto an internal surface of the blood vessel and exert a radial force on said internal surface.

An endovascular graft is provided that includes a stent structure adapted to move between a collapsed and a deployed configuration. An endovascular graft material is mounted with respect to the stent structure. At least one lumen- or chute-forming structure is associated with the stent structure internal to the endovascular graft material. The at least one lumen- or chute-forming structure is adapted to move between a first position and a second position, wherein the at least one lumen- or chute-forming structure is rolled within itself in the first position, and wherein the at least one lumen- or chute-forming structure moves from the first position to the second position by unrolling. When in the second position, the at least one lumen- or chute-forming structure defines a passage having a greater cross-sectional area as compared to the first position. Stent-graft deployment to one or more branch arteries/vessels may be accomplished through the at least one lumen- or chute-forming structure. The present disclosure also provides advantageous methods for deploying the disclosed endovascular graft and delivery of stent-grafts to branch arteries/vessels therethrough.