There are provided, inter alia, compounds and methods useful for the treatment of neurological conditions, such as neurological disorders and neurodegenerative diseases, including Alzheimer's Disease.

The application describes an assay for the identification of small molecule modulators of integrin CD11b/CD18 and small molecules capable of modulating activity of this receptor. Such compounds may be used in certain embodiments for treating a disease or condition selected from inflammation, immune-related disorders, cancer, ischemia-reperfusion injury, stroke, neointimal thickening associated with vascular injury, bullous pemphigoid, neonatal obstructive nephropathy, and cardiovascular disease, or in other embodiments for the treatment of a disease or condition selected from immune deficiency, acquired immune deficiency syndrome (AIDS), myeloperoxidase deficiency, Wiskott-Aldrich syndrome, chronic granulomatous disease, hyper-IgM syndromes, leukocyte adhesion deficiency, Chediak-Higashi syndrome, and severe combined immunodeficiency.

The application describes an assay for the identification of small molecule modulators of integrin CD11b/CD18 and small molecules capable of modulating activity of this receptor. Such compounds may be used in certain embodiments for treating a disease or condition selected from inflammation, immune-related disorders, cancer, ischemia-reperfusion injury, stroke, neointimal thickening associated with vascular injury, bullous pemphigoid, neonatal obstructive nephropathy, and cardiovascular disease, or in other embodiments for the treatment of a disease or condition selected from immune deficiency, acquired immune deficiency syndrome (AIDS), myeloperoxidase deficiency, Wiskott-Aldrich syndrome, chronic granulomatous disease, hyper-IgM syndromes, leukocyte adhesion deficiency, Chediak-Higashi syndrome, and severe combined immunodeficiency.

An object of the present invention is to provide a colored photosensitive resin composition capable of forming a color filter having a higher brightness than that of the color filter formed from the conventionally known colored photosensitive resin composition. The colored photosensitive resin composition according to the present invention comprises a colorant, a resin, a polymerizable compound, and a polymerization initiator, the colorant comprising a compound represented by formula (1) and an ?-type and/or ?-type copper phthalocyanine pigment, ##STR00001##
wherein M.sup.r+ represents an r-valent metal ion; k represents the sum of the number of SO.sub.3.sup.? and the number of SO.sub.2N.sup.?SO.sub.2R.sup.f in the compound represented by formula (1); r represents an integer of 1 or more; R.sup.f represents a fluoroalkyl group having 1 to 12 carbon atoms; and the compound represented by formula (1) has at least one SO.sub.3.sup.? or SO.sub.2N.sup.?SO.sub.2R.sup.f.

Provided are, inter alia, compounds having a structure of Formulae (X) to (XVII), or a subordinate structure thereof, composition including the same and methods of use.

Provided are, inter alia, compounds having a structure of Formulae (X) to (XVII), or a subordinate structure thereof, composition including the same and methods of use.

This invention is directed to neuroprotective compositions and methods of using the same to treat neurodegenerative diseases.

The present invention is directed to compounds, their synthesis, and their use as antagonists, inverse agonists, modulators and or inhibitors of the Retinoic acid-related orphan nuclear receptor t (RORt)/ROR. The compounds of the present invention are useful for modulating RORt)/ROR activity and for treating diseases or conditions mediated by RORt)/ROR such as for example, disease states associated with immunopathology of human autoimmune diseases such as Multiple Sclerosis (MS), Rheumatoid Arthritis (RA), Inflammatory Colitis, Psoriasis, COPD, Pain, Obesity, Diabetes, Dyslipidemia, Osteoporosis, Asthma, Neurodegenerative diseases and Cancer.

The present invention is directed to compounds, their synthesis, and their use as antagonists, inverse agonists, modulators and or inhibitors of the Retinoic acid-related orphan nuclear receptor t (RORt)/ROR. The compounds of the present invention are useful for modulating RORt)/ROR activity and for treating diseases or conditions mediated by RORt)/ROR such as for example, disease states associated with immunopathology of human autoimmune diseases such as Multiple Sclerosis (MS), Rheumatoid Arthritis (RA), Inflammatory Colitis, Psoriasis, COPD, Pain, Obesity, Diabetes, Dyslipidemia, Osteoporosis, Asthma, Neurodegenerative diseases and Cancer.

This heat-sensitive recording material is configured to contain, as a color-developing compound, at least one compound represented by one of formulas (1)-(3): ##STR00001##