The invention relates to N-hydroxysulfonamide derivatives that donate nitroxyl (HNO) under physiological conditions and are useful in treating and/or preventing the onset and/or development of diseases or conditions that are responsive to nitroxyl therapy, including heart failure and ischemia/reperfusion injury. Novel N-hydroxysulfonamide derivatives release HNO at a controlled rate under physiological conditions, and the rate of HNO release is modulated by varying the nature and location of functional groups on the N-hydroxysulfonamide derivatives.

The invention relates to novel heterocyclic compounds and pharmaceutical preparations thereof. The invention further relates to methods of treatment using the novel heterocyclic compounds of the invention.

The invention relates to novel heterocyclic compounds and pharmaceutical preparations thereof. The invention further relates to methods of treatment using the novel heterocyclic compounds of the invention.

Disclosed herein are corrosion inhibitors suitable for heavy-duty industrial lubricants and industrial lubricating compositions including such corrosion inhibitors combined with phosphonate diesters to provide good copper corrosion and roller bearing protection. The corrosion inhibitor has a high content of dialkyl dithiothiadiazole compounds configured to maintain high levels of the phosphonate diester in the lubricant.

Disclosed herein are corrosion inhibitors suitable for heavy-duty industrial lubricants and industrial lubricating compositions including such corrosion inhibitors combined with phosphonate diesters to provide good copper corrosion and roller bearing protection. The corrosion inhibitor has a high content of dialkyl dithiothiadiazole compounds configured to maintain high levels of the phosphonate diester in the lubricant.

The present invention relates to a process for the preparation of bis(dimercaptothiadiazole) (or bis-DMTD), more particularly of 5,5-dithiobis(1,3,4-thiadiazole-2-thiol), said process being carried out in a single reactor and making possible a preparation with improved yields which is more respectful of the environment.

The present invention relates to a process for the preparation of bis(dimercaptothiadiazole) (or bis-DMTD), more particularly of 5,5-dithiobis(1,3,4-thiadiazole-2-thiol), said process being carried out in a single reactor and making possible a preparation with improved yields which is more respectful of the environment.

The invention relates to N-hydroxysulfonamide derivatives that donate nitroxyl (HNO) under physiological conditions and are useful in treating and/or preventing the onset and/or development of diseases or conditions that are responsive to nitroxyl therapy, including heart failure and ischemia/reperfusion injury. Novel N-hydroxysulfonamide derivatives release HNO at a controlled rate under physiological conditions, and the rate of HNO release is modulated by varying the nature and location of functional groups on the N-hydroxysulfonamide derivatives.

The invention relates to N-hydroxysulfonamide derivatives that donate nitroxyl (HNO) under physiological conditions and are useful in treating and/or preventing the onset and/or development of diseases or conditions that are responsive to nitroxyl therapy, including heart failure and ischemia/reperfusion injury. Novel N-hydroxysulfonamide derivatives release HNO at a controlled rate under physiological conditions, and the rate of HNO release is modulated by varying the nature and location of functional groups on the N-hydroxysulfonamide derivatives.

Disclosed herein are compounds of Formula (I), methods of synthesizing compounds of Formula (I), and methods of using compounds of Formula (I) as an analgesic.