Patent classifications
C07D307/85
SELECTIVE D3 DOPAMINE RECEPTOR AGONISTS AND METHODS OF THEIR USE
The disclosure of a compound of Formula (I) or a pharmaceutically acceptable salt thereof (I) The variables W, R.sup.1, R.sup.2, R.sup.3, and R.sup.4 are defined in the disclosure. The disclosure provides a compound or salt of Formula (I) together with a pharmaceutically acceptable carrier. The disclosure also provides methods of treating a patient for Parkinson's disease and related syndromes, dyskinesia, especially dyskinesias secondary to treating Parkinson's disease with L-DOPA, neurodegenerative disorders such as Alzheimer's disease and dementia, Huntington's disease, restless legs syndrome, bipolar disorder and depression, schizophrenia, cognitive dysfunction, or substance use disorders, the methods comprising administering a compound of Formula I or salt thereof to the patient. The disclosure provides combination methods of treatment in which the compound of Formula (I) is administered to the patient together with one or more additional active agents.
INHIBITORS OF INTEGRATED STRESS RESPONSE PATHWAY
The present disclosure relates generally to therapeutic agents that may be useful as inhibitors of Integrated Stress Response (ISR) pathway.
AMIDE DERIVATIVES, PROCESS FOR PREPARATION THEREOF AND USE THEREOF AS INSECTICIDE
A compound represented by Formula (1):
##STR00001##
The compound can be used as insecticides.
AMIDE DERIVATIVES, PROCESS FOR PREPARATION THEREOF AND USE THEREOF AS INSECTICIDE
A compound represented by Formula (1):
##STR00001##
The compound can be used as insecticides.
MODULATORS OF THE INTEGRATED STRESS PATHWAY
Provided herein are compounds, compositions, and methods useful for modulating the integrated stress response (ISR) and for treating related diseases, disorders and conditions.
MODULATORS OF THE INTEGRATED STRESS PATHWAY
Provided herein are compounds, compositions, and methods useful for modulating the integrated stress response (ISR) and for treating related diseases, disorders and conditions.
BIOACTIVE POLYMERS WITH ANTI=FOULING PROPERTIES FOR MEDICAL AND DENTAL USES
The present invention provides polymers capable of inhibiting the growth of biofilms, including biofilms of Streptococcus mutans. The invention also provides monomers for use in the preparation of such polymers.
BIOACTIVE POLYMERS WITH ANTI=FOULING PROPERTIES FOR MEDICAL AND DENTAL USES
The present invention provides polymers capable of inhibiting the growth of biofilms, including biofilms of Streptococcus mutans. The invention also provides monomers for use in the preparation of such polymers.
Amide derivatives, process for preparation thereof and use thereof as insecticide
A compound represented by Formula (1): ##STR00001## The compound can be used as insecticides.
Amide derivatives, process for preparation thereof and use thereof as insecticide
A compound represented by Formula (1): ##STR00001## The compound can be used as insecticides.