The present invention relates to novel 3-ketocoumarins with improved water compatibility, which are useful as photoinitiators and to compositions comprising said photoinitiators. The invention also relates to compositions comprising said novel 3-ketocoumarins and to a process for photopolymerizing comprising them.

The present disclosure provides a non-aqueous electrolyte including an additive for a non-aqueous electrolyte, which is represented by the following Chemical Formula 1:

##STR00001##

In Chemical Formula 1, R.sub.1 to R.sub.5 are each independently any one selected from the group consisting of H, an alkyl group having 1 to 10 carbon atoms, and an alkoxy group having 1 to 10 carbon atoms, and R may be an aliphatic unsaturated hydrocarbon group having 2 to 10 carbon atoms, or —OR′ (R′ is an aliphatic unsaturated hydrocarbon group having 2 to 10 carbon atoms).

The present disclosure provides a non-aqueous electrolyte including an additive for a non-aqueous electrolyte, which is represented by the following Chemical Formula 1:

##STR00001##

In Chemical Formula 1, R.sub.1 to R.sub.5 are each independently any one selected from the group consisting of H, an alkyl group having 1 to 10 carbon atoms, and an alkoxy group having 1 to 10 carbon atoms, and R may be an aliphatic unsaturated hydrocarbon group having 2 to 10 carbon atoms, or —OR′ (R′ is an aliphatic unsaturated hydrocarbon group having 2 to 10 carbon atoms).

Subject-matter of the present invention are novel 3-ketocoumarins, a process for their preparation and their use as photoinitiators in photopolymerization reactions, advantageously in photopolymerization reactions for inkjet printing inks. The invention also concerns a process for the photopolymerization of compositions also comprising said 3-ketocoumarins.

Subject-matter of the present invention are novel 3-ketocoumarins, a process for their preparation and their use as photoinitiators in photopolymerization reactions, advantageously in photopolymerization reactions for inkjet printing inks. The invention also concerns a process for the photopolymerization of compositions also comprising said 3-ketocoumarins.

A quaternary ammonium salt comprising a chromophore constituent, a tertiary amine cation constituent connected to the para-position of the chromophore constituent via a methylene linkage, and a borate anion constituent, wherein chromophore constituent is a 3-ketocoumarin constituent or a benzophenone constituent. Also, a photobase-redox initiating system comprising the quaternary ammonium salt and a peroxide.

A quaternary ammonium salt comprising a chromophore constituent, a tertiary amine cation constituent connected to the para-position of the chromophore constituent via a methylene linkage, and a borate anion constituent, wherein chromophore constituent is a 3-ketocoumarin constituent or a benzophenone constituent. Also, a photobase-redox initiating system comprising the quaternary ammonium salt and a peroxide.

The present disclosure provides compounds, compositions containing such compounds, and methods of designing, developing, producing and preparing compounds represented by general Formula (I), including pharmaceutically acceptable salts thereof or a synthetic intermediate thereof:

##STR00001##

The compounds act as MEK inhibitors and are capable of displaying one or more beneficial therapeutic effects, including treating cancer.

The present invention relates to a compound of the general formula I and the pharmaceutically acceptable salts thereof; where the variables are as defined in the claims and the description. The invention also relates to the compounds of formula I for use in the treatment or prophylaxis of muscle wasting conditions, of skeletal or cardial muscle atrophy, of conditions, in particular of myopathies, which are associated with an increased Muscle RING Finger 1 (MuRF1) expression and of other conditions; to the compounds of formula I for use as a medicament; to a pharmaceutical composition comprising at least one compound of formula I and to a method for treating said conditions.

##STR00001##

The present invention relates to a method for preparing coumarin compounds substituted by amidoalkyl at 3-position, and related intermediates thereof. The method includes: Step (A): reacting a compound of formula (VI) with a compound of formula (V) to give a compound of formula (VII)

##STR00001## wherein R.sub.1 and R.sub.2 are each independently selected from hydrogen, halogen, and —O(C.sub.1-8 alkyl), wherein the alkyl is optionally substituted with 1 or 2 groups selected from the group consisting of halogen, C.sub.1-8 alkyl substituted with 1-2 hydroxyl groups, —O(C.sub.1-8 alkyl); R.sub.3 is -L-C(O)NR.sub.5R.sub.6, L is C.sub.1-3 alkylene.