The invention relates to compositions and methods for inhibiting Krüppel-like Factor 10 (KLF10) for modulation of T regulatory cells and cancer immunotherapy.

The invention relates to compositions and methods for inhibiting Krüppel-like Factor 10 (KLF10) for modulation of T regulatory cells and cancer immunotherapy.

The present disclosure provides a novel process for the continuous extraction, purification and production of a flavan-3-ol extract from early harvested whole grape clusters. The final product from this process is particularly rich in monomeric and oligomeric flavan-3-ols and with an unusually high conversion of the final product into flavan-3-ol subunits under acid catalysis conditions. The oligomers and polymers in the final product are frequently referred to as proanthocyanidins in the field of polyphenol chemistry. The disclosure provides a novel process for the production of the final product via a continuous extraction process and with a final product having a unique composition.

The present invention relates to the technical field of bioengineering and provides a method for efficient extraction of plant anthocyanidin. The method comprises steps of: hydrolyzing anthocyanin; using one of sodium bicarbonate or potassium bicarbonate NaHCO.sub.3/KHCO.sub.3 to neutralize an aqueous solution obtained after the anthocyanin hydrolysis to pH 7; using a saturated aqueous solution of sodium chloride or potassium chloride NaCl/Kcl to perform salting out for suspended separation of a conjugate of an anthocyanidin sodium salt or potassium salt and a fatty acid or fatty acid ester; allowing aqueous hydrochloric acid to react with the anthocyanidin sodium salt or potassium salt; and filtering and separating an anthocyanidin aqueous solution. The present invention is applied to the extraction of natural plant anthocyanidin.

The present invention relates to the technical field of bioengineering and provides a method for efficient extraction of plant anthocyanidin. The method comprises steps of: hydrolyzing anthocyanin; using one of sodium bicarbonate or potassium bicarbonate NaHCO.sub.3/KHCO.sub.3 to neutralize an aqueous solution obtained after the anthocyanin hydrolysis to pH 7; using a saturated aqueous solution of sodium chloride or potassium chloride NaCl/Kcl to perform salting out for suspended separation of a conjugate of an anthocyanidin sodium salt or potassium salt and a fatty acid or fatty acid ester; allowing aqueous hydrochloric acid to react with the anthocyanidin sodium salt or potassium salt; and filtering and separating an anthocyanidin aqueous solution. The present invention is applied to the extraction of natural plant anthocyanidin.

The present document describes apple peel polyphenolic extract comprising a proanthocyanidin content of at least 15000 μg/g of dry weight, comprising about 30% to about 35% epicatechin content, and pharmaceutical composition comprising the apple peel polyphenolic extract. The present document also describes methods and use of the apple peel polyphenolic extract for preventing or treating conditions such as oxidative stress, inflammation and mitochondrial dysfunction of the liver, insulin resistance, intestinal endothelial tissue injury, non-alcoholic fatty liver disease, non-alcoholic steatohepatitis (NASH), liver fibrosis, liver cirrhosis, and/or inhibition of de novo lipogenesis and β-oxidation of free fatty acids for preventing accumulation thereof in the liver. The present document also describes a process for extraction of at least a polyphenol content from dry apple peel powder.

Methods for converting mixtures of anthocyanins occurring in fruit or vegetable juice or extract into particular anthocyanin molecules having desirable colorant properties are provided herein. The method of the present disclosure can be employed to increase the amount of particular anthocyanin molecules, while lowering the total number of anthocyanin molecules present in the natural juice and/or extract. The disclosure is also directed to anthocyanin molecules prepared by the methods of present disclosure and to enzymes capable of catalyzing reactions that provide such effects.

Disclosed herein are active agents, compositions containing them, unit dosage forms containing them, and methods of their use, e.g., for treating a metabolic disorder or nonalcoholic fatty liver disease or for modulating a metabolic marker or nonalcoholic fatty liver disease marker.

[PROBLEM] To provide a novel method for synthesising a polyphenol. [SOLUTION] A polyphenol production method including the reaction of catechin in the presence of a catalyst and an oxidising agent, said catalyst comprising a metal oxide and/or a composite that comprises: a substrate which has an inorganic material on the surface thereof; and metal nanoparticles of a particle diameter of 0.5-100 nm attached to the surface of the inorganic material.

The present disclosure generally provides a class of flavanone derivatives and their use as sweetness enhancers. In some aspects, the disclosure provides certain compositions that include such flavanone derivatives, such as compositions that include such flavanone derivatives and one or more other sweeteners. In some other aspects, the disclosure provides methods of reducing the caloric content of a sweetened article, such as a sweetened food or beverage product.