The invention relates to a method for producing 2,3,5-trimethyl benzoquinone or a compound containing 2,3,5-trimethyl benzoquinone, the method comprising the following steps: Oxidation of 2,3,6-trimethylphenol with oxygen or an oxygen-containing gas in a two- or multi-phase reaction medium in the presence of a catalyst or catalyst system containing at least one copper (II)-halide to a mixture containing 2,3,5-trimethyl benzoquinone, characterized in that the reaction medium contains water and at least one secondary aliphatic acyclic alcohol having 6 or more, preferably 7 or more, carbon atoms.

The invention relates to a method for producing 2,3,5-trimethyl benzoquinone or a compound containing 2,3,5-trimethyl benzoquinone, the method comprising the following steps: Oxidation of 2,3,6-trimethylphenol with oxygen or an oxygen-containing gas in a two- or multi-phase reaction medium in the presence of a catalyst or catalyst system containing at least one copper (II)-halide to a mixture containing 2,3,5-trimethyl benzoquinone, characterized in that the reaction medium contains water and at least one secondary aliphatic acyclic alcohol having 6 or more, preferably 7 or more, carbon atoms.

The present invention relates to the use of prodrugs susceptible to nitroreductase (NTR) activation. In particular, provided herein are mitochondria-targeting prodrug compounds and probes, including profluorescent near-infrared (NIR) probes and non-fluorescent prodrugs, as well as to methods of using said prodrug compounds and probes for imaging mitochondria and for mitochondria-specific delivery of therapeutic agents.

A method of producing refined oils and/or fats whereby the content of, e.g., glycidol, can be reduced and reductions in the content of tocopherols can be inhibited, and a method for producing low-impurity tocopherols. The method includes a first distillation step of subjecting raw material oils and/or fats to thin film distillation under a first condition; a second distillation step of subjecting a first distillate fraction obtained after the first distillation step to thin film distillation under a second condition; a third distillation step of subjecting a second residual fraction obtained after the second distillation step to thin film distillation under a third condition; and a mixing step of obtaining a mixed oil by mixing a first residual fraction obtained after the first distillation step, with a third distillate fraction obtained after the third distillation step. The first, second, and third conditions include specified temperature conditions and pressure conditions.

A method of producing refined oils and/or fats whereby the content of, e.g., glycidol, can be reduced and reductions in the content of tocopherols can be inhibited, and a method for producing low-impurity tocopherols. The method includes a first distillation step of subjecting raw material oils and/or fats to thin film distillation under a first condition; a second distillation step of subjecting a first distillate fraction obtained after the first distillation step to thin film distillation under a second condition; a third distillation step of subjecting a second residual fraction obtained after the second distillation step to thin film distillation under a third condition; and a mixing step of obtaining a mixed oil by mixing a first residual fraction obtained after the first distillation step, with a third distillate fraction obtained after the third distillation step. The first, second, and third conditions include specified temperature conditions and pressure conditions.

Polyolefin compositions of a polyolefin, a chroman-based compound according to Formula (V):

##STR00001##

and a basic co-additive selected from alkali metal or alkaline metal salts of higher fatty acids are disclosed. Amounts of the chroman-based compound and the basic co-additive are selected to enhance processing stability of the polyolefin composition when subjected to extrusion, even in the absence of antistatic agents and organic phosphites and phosphonites. Masterbatch compositions of a first polyolefin, the chroman-based compound and the basic co-additive can be blended with a second polyolefin, identical to, or compatible with, the first polyolefin to form a stabilized polyolefin composition. Molded articles produced by molding the polyolefin compositions are also disclosed. R.sub.21, R.sub.22, R.sub.23, R.sub.24, R.sub.25, R.sub.26, and R.sub.27 are also described.

Polyolefin compositions of a polyolefin, a chroman-based compound according to Formula (V):

##STR00001##

and a basic co-additive selected from alkali metal or alkaline metal salts of higher fatty acids are disclosed. Amounts of the chroman-based compound and the basic co-additive are selected to enhance processing stability of the polyolefin composition when subjected to extrusion, even in the absence of antistatic agents and organic phosphites and phosphonites. Masterbatch compositions of a first polyolefin, the chroman-based compound and the basic co-additive can be blended with a second polyolefin, identical to, or compatible with, the first polyolefin to form a stabilized polyolefin composition. Molded articles produced by molding the polyolefin compositions are also disclosed. R.sub.21, R.sub.22, R.sub.23, R.sub.24, R.sub.25, R.sub.26, and R.sub.27 are also described.

The present invention relates to the (S) enantiomeric form of certain 6-chromanol derivatives for use as a medicament. Especially, the present invention relates to the (S) enantiomeric form of a 6-chromanol derivative for use as a medicament wherein said 6-chromanol derivative is chosen from the group consisting of (6-hydroxy-2,5,7,8-tetramethylchroman-2-yl)(piperazin-1-yl)methanone; N-(benzyl)-6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxamide; N-(phenyl)-6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxamide; methyl 4-(6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxamido)benzoate; (6-hydroxy-2,5,7,8-tetramethylchroman-2-yl)(morpholino)methanone, and pharmaceutically acceptable salts or bases thereof and pharmaceutically acceptable salts thereof.

The present invention relates to a novel synthetic pathway for alpha-tocopherol. The invention discloses different reactions yielding some new intermediates in a very high yield and stereoselectivity.

The present invention relates to a novel synthetic pathway for alpha-tocopherol. The invention discloses different reactions yielding some new intermediates in a very high yield and stereoselectivity.