The present embodiments are directed to compositions of quinones and/or quinols, such as, but not limited to, ubiquinone and/or ubiquinol, vitamin E quinone and/or vitamin E quinol, vitamin K quinone and/or vitamin K quinol, menaquinones and/or menaquinols, and pyrroloquinoline quinone and/or pyrroloquinoline quinol, and methods for preparations and use thereof. The present embodiments are also directed to compositions of reduced forms of curcuminoid and methods for preparations and use thereof.

A method of stabilizing radical ethylene copolymerization reactions for approximately 5 to 10 minutes, the method including using a phenolic compound with other comonomers and performing the radical ethylene copolymerization reactions at high pressure. Also, a method of preparing an ethylene copolymer at high pressure in the presence of one or more phenolic compounds, as defined below, and one or more initiators.

A method of stabilizing radical ethylene copolymerization reactions for approximately 5 to 10 minutes, the method including using a phenolic compound with other comonomers and performing the radical ethylene copolymerization reactions at high pressure. Also, a method of preparing an ethylene copolymer at high pressure in the presence of one or more phenolic compounds, as defined below, and one or more initiators.

The present invention is directed towards the use of substituted chroman-6-ols with extended lipophilic side chains of formula (I) wherein one of the two substituents R.sup.1 and R.sup.2 is C.sub.12-21-alkyl and the other of the two substituents R.sup.1 and R.sup.2 is either hydrogen or C.sub.1-5-alkyl or (CH.sub.2).sub.n—OH with n being an integer from 1 to 5, and wherein A is CH(R.sup.3), and wherein R.sup.3, R.sup.4 and R.sup.6 are independently from each other H or C.sub.1-4-alkyl, and wherein R.sup.5 is H or OH or C.sub.1-4-alkyl or C.sub.1-4-alkoxy; with the proviso that at least two of R.sup.4, R.sup.5 and R.sup.6 are not methyl, when R.sup.3 is H and one of the substituents R.sup.1 and R.sup.2 is methyl and the other of the two substituents R.sup.1 and R.sup.2 is C.sub.12-21-alkyl, as antioxidants, especially in feed such as pet food and feed ingredients such as fish meal, insect meal and poultry meal, as well as PUFA-containing oil such as marine oil, microbial oil, fungal oil, algal oil and PUFA-containing plant oil. The present invention is further directed towards feed ingredients and feed for insects, aquatic and terrestrial animals comprising such substituted chroman-6-ols with extended lipophilic side chains of formula (I). ##STR00001##

The present invention is directed towards the use of substituted chroman-6-ols with extended lipophilic side chains of formula (I) wherein one of the two substituents R.sup.1 and R.sup.2 is C.sub.12-21-alkyl and the other of the two substituents R.sup.1 and R.sup.2 is either hydrogen or C.sub.1-5-alkyl or (CH.sub.2).sub.n—OH with n being an integer from 1 to 5, and wherein A is CH(R.sup.3), and wherein R.sup.3, R.sup.4 and R.sup.6 are independently from each other H or C.sub.1-4-alkyl, and wherein R.sup.5 is H or OH or C.sub.1-4-alkyl or C.sub.1-4-alkoxy; with the proviso that at least two of R.sup.4, R.sup.5 and R.sup.6 are not methyl, when R.sup.3 is H and one of the substituents R.sup.1 and R.sup.2 is methyl and the other of the two substituents R.sup.1 and R.sup.2 is C.sub.12-21-alkyl, as antioxidants, especially in feed such as pet food and feed ingredients such as fish meal, insect meal and poultry meal, as well as PUFA-containing oil such as marine oil, microbial oil, fungal oil, algal oil and PUFA-containing plant oil. The present invention is further directed towards feed ingredients and feed for insects, aquatic and terrestrial animals comprising such substituted chroman-6-ols with extended lipophilic side chains of formula (I). ##STR00001##

The invention discloses novel processes for production, enrichment and/or isolation of alpha-tocotrienol from source material comprising at least one non-alpha-tocotrienol, such as natural extracts comprising mixed tocotrienols.

The invention discloses novel processes for production, enrichment and/or isolation of alpha-tocotrienol from source material comprising at least one non-alpha-tocotrienol, such as natural extracts comprising mixed tocotrienols.

A stabilizer composition for producing a polymeric hollow article in a rotomolding process has stabilizing amounts of: (i) at least one chroman-based compound according to Formula (V):

##STR00001##

wherein at least one instance of R.sub.21 is OR.sub.27, R.sub.27 is COR′″ or Si(R.sub.28).sub.3, and R′″, R.sub.22, R.sub.23 R.sub.24, R.sub.25 and R.sub.26 are as defined herein; (ii) at least one phosphite or phosphonite; and (iii) a basic co-additive selected from alkali metal or alkaline metal salts of higher fatty acids. A polymeric hollow article is made by a process comprising: a) filling a mold with a polyolefin and a stabilizing amount of the stabilizer composition described herewith; b) rotating the mold around at least one axis while heating the mold in an oven, thereby fusing the composition and spreading it to the walls of the mold; c) cooling the mold; and d) opening the mold to remove the resulting polymeric hollow article.

A stabilizer composition for producing a polymeric hollow article in a rotomolding process has stabilizing amounts of: (i) at least one chroman-based compound according to Formula (V):

##STR00001##

wherein at least one instance of R.sub.21 is OR.sub.27, R.sub.27 is COR′″ or Si(R.sub.28).sub.3, and R′″, R.sub.22, R.sub.23 R.sub.24, R.sub.25 and R.sub.26 are as defined herein; (ii) at least one phosphite or phosphonite; and (iii) a basic co-additive selected from alkali metal or alkaline metal salts of higher fatty acids. A polymeric hollow article is made by a process comprising: a) filling a mold with a polyolefin and a stabilizing amount of the stabilizer composition described herewith; b) rotating the mold around at least one axis while heating the mold in an oven, thereby fusing the composition and spreading it to the walls of the mold; c) cooling the mold; and d) opening the mold to remove the resulting polymeric hollow article.

The present invention provides compounds suitable for use in the treatment of conditions where it is beneficial to halt bone loss and kill cancer cells, particularly in metastases to and primary tumours in the bone and surrounding tissues. Consequently the present invention provides compounds comprising a bisphosphonate moiety linked to a phytochemical, pharmaceutical compositions thereof and methods of treatment of bone diseases and/or proliferative disorders.