Described are polymerizable high energy light absorbing compounds. The compounds absorb various wavelengths of ultraviolet and/or high energy visible light and are suitable for incorporation in various products, such as biomedical devices and ophthalmic devices.

A new class of pH sensitive fluorescent dyes and assays relating thereto are described. The dyes and assays are particularly suited for biological applications including phagocytosis and monitoring intracellular processes. The pH sensitive fluorescent dyes of the present invention include compounds of Formula I:

##STR00001## wherein the variables are described throughout the application.

A new class of pH sensitive fluorescent dyes and assays relating thereto are described. The dyes and assays are particularly suited for biological applications including phagocytosis and monitoring intracellular processes. The pH sensitive fluorescent dyes of the present invention include compounds of Formula I:

##STR00001## wherein the variables are described throughout the application.

A fluorescent probe can be used to detect and visualize carboxypeptidase activity with high sensitivity. The fluorescent probe has, as a base nucleus, a fluorescent skeleton that functions in the visible light region, and makes carboxypeptidase activity detectable and visible, for example, within a cell or clinical specimen, with high sensitivity.

A fluorescent probe can be used to detect and visualize carboxypeptidase activity with high sensitivity. The fluorescent probe has, as a base nucleus, a fluorescent skeleton that functions in the visible light region, and makes carboxypeptidase activity detectable and visible, for example, within a cell or clinical specimen, with high sensitivity.

Described are polymerizable high energy light absorbing compounds. The compounds absorb various wavelengths of ultraviolet and/or high energy visible light and are suitable for incorporation in various products, such as biomedical devices and ophthalmic devices.

The present disclosure relates to compounds that are useful as near-infrared fluorescence probes, wherein the compounds include i) a ligand that binds to the active site of carbonic anhydrase, ii) a dye molecule, and iii) a linker molecule that comprises an amino acid, amide, ureido, or polyethylene glycol derivative thereof. The disclosure further describes methods and compositions for making and using the compounds, methods incorporating the compounds, and kits incorporating the compounds.

The present disclosure relates to compounds that are useful as near-infrared fluorescence probes, wherein the compounds include i) a ligand that binds to the active site of carbonic anhydrase, ii) a dye molecule, and iii) a linker molecule that comprises an amino acid, amide, ureido, or polyethylene glycol derivative thereof. The disclosure further describes methods and compositions for making and using the compounds, methods incorporating the compounds, and kits incorporating the compounds.

Described are polymerizable fused tricyclic compounds of formula I:

##STR00001##

wherein R.sup.1, R.sup.2, R.sup.3, m, n, t, and rings B, C, and D are as defined herein. The compounds absorb various wavelengths of ultraviolet and/or visible light (such as high energy visible light) and are suitable for incorporation in a variety of products, such as biomedical devices and ophthalmic devices.

An organic electroluminescent device contains an anode, a cathode, and an organic layer containing at least one luminous layer. The organic layer is disposed between the anode and the cathode. At least one luminous layer contains a -conjugated compound exhibiting no overlap between the electron density distributions of the HOMO and the LUMO in the molecule, such that electron transition between the HOMO and the LUMO occurs by a through-space interaction in the molecule. The -conjugated compound has a -conjugated aromatic ring at a moiety on which at least one of the HOMO and the LUMO is localized.