Patent classifications
C07D333/40
Dual mechanism inhibitors for the treatment of disease
Provided are compounds that are inhibitors of both rho kinase and of a monoamine transporter (MAT) act to improve the disease state or condition. Further provided are compositions comprising the compounds. Further provided are methods for treating diseases or conditions, the methods comprising administering compounds according to the invention. One such disease may be glaucoma for which, among other beneficial effects, a marked reduction in intraocular pressure (IOP) may be achieved.
Dual mechanism inhibitors for the treatment of disease
Provided are compounds that are inhibitors of both rho kinase and of a monoamine transporter (MAT) act to improve the disease state or condition. Further provided are compositions comprising the compounds. Further provided are methods for treating diseases or conditions, the methods comprising administering compounds according to the invention. One such disease may be glaucoma for which, among other beneficial effects, a marked reduction in intraocular pressure (IOP) may be achieved.
FABP4/5 INHIBITORS, METHODS OF USE AND METHODS OF MAKING
Disclosed herein are FABP4 and FABP5 inhibitor compounds and their use in pharmaceutical compositions for treating diseases relating to fatty acid metabolism, including cancer. Also disclosed herein are methods for preparing the disclosed compounds.
FABP4/5 INHIBITORS, METHODS OF USE AND METHODS OF MAKING
Disclosed herein are FABP4 and FABP5 inhibitor compounds and their use in pharmaceutical compositions for treating diseases relating to fatty acid metabolism, including cancer. Also disclosed herein are methods for preparing the disclosed compounds.
SALT, ACID GENERATOR, RESIST COMPOSITION AND METHOD FOR PRODUCING RESIST PATTERN
Disclosed are a salt represented by formula (I), an acid generator, and a resist composition including the same:
##STR00001##
wherein R.sup.4 to R.sup.9 each represent a halogen atom, a haloalkyl group, etc., A.sup.1, A.sup.2 and A.sup.3 each represent a hydrocarbon group, the group may have a substituent, —CH.sub.2— in the group may be replaced by —O—, —CO—, —S—, etc., X.sup.4, X.sup.5 and X.sup.6 each represent —O— or —S—, m1 represents an integer of 1 to 5, m2, m3, m8 and m9 represent an integer of 0 to 5, m4, m5 and m6 represent an integer of 0 to 3, m7 represents an integer of 0 to 4, 1≤m1+m7≤5, 0≤m2+m8≤5, 0≤m3+m9≤5, and AI.sup.− represents an organic anion.
SALT, ACID GENERATOR, RESIST COMPOSITION AND METHOD FOR PRODUCING RESIST PATTERN
Disclosed are a salt represented by formula (I), an acid generator, and a resist composition including the same:
##STR00001##
wherein R.sup.4 to R.sup.9 each represent a halogen atom, a haloalkyl group, etc., A.sup.1, A.sup.2 and A.sup.3 each represent a hydrocarbon group, the group may have a substituent, —CH.sub.2— in the group may be replaced by —O—, —CO—, —S—, etc., X.sup.4, X.sup.5 and X.sup.6 each represent —O— or —S—, m1 represents an integer of 1 to 5, m2, m3, m8 and m9 represent an integer of 0 to 5, m4, m5 and m6 represent an integer of 0 to 3, m7 represents an integer of 0 to 4, 1≤m1+m7≤5, 0≤m2+m8≤5, 0≤m3+m9≤5, and AI.sup.− represents an organic anion.
Compounds as chloride channel blocking agent
Disclosed is a novel compound to function as a calcium-dependent chloride channel blocking agent.
Compounds as chloride channel blocking agent
Disclosed is a novel compound to function as a calcium-dependent chloride channel blocking agent.
INSECT REPELLENT COMPOUNDS AND COMPOSITIONS, AND METHODS THEREOF
The present invention relates to monoterpenoid and phenylpropanoid containing derivative compounds, methods of making the compounds, compositions comprising the compounds, and methods of repelling pests using the compounds and/or compositions.
INSECT REPELLENT COMPOUNDS AND COMPOSITIONS, AND METHODS THEREOF
The present invention relates to monoterpenoid and phenylpropanoid containing derivative compounds, methods of making the compounds, compositions comprising the compounds, and methods of repelling pests using the compounds and/or compositions.