The present invention relates to an indole compound of Formula (I) or pharmaceutically acceptable salt thereof, and process for the preparation thereof. The present invention also relates to a pharmaceutical composition of indole compound of Formula (I) or pharmaceutically acceptable salt thereof for treating mycobacterial infection or antimalarial infection or antifungal infection in a subject in need thereof. ##STR00001##

A catalyzed hydroformylation process of an alkenyl-functional organosilicon compound with carbon monoxide and hydrogen produces an aldehyde-functional organosilicon compound.

The present application relates to a preparation method for a pyrrolopyrimidine compound, comprising: obtaining a compound 3 from a compound 2, obtaining a compound 4P2 from the compound 3, and obtaining a pyrrolopyrimidine compound of formula I by removing a protecting group from the compound 4P2. The preparation method of the present application has the advantages of simple operation, mild reaction conditions and high yield, avoids the problems of low yield and a large amount of impurities and difficult separation of same in original routes, reduces production costs, and is suitable for industrial production. Furthermore, the product yield of each step is high, and basically reaches about 80%, and even the yield of some steps can reach 90% or more.

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The present invention relates to a process for preparing alectinib, or a pharmaceutically acceptable salt thereof, and to related intermediates.

A thermally activated delayed fluorescent monomolecular white light material, a method of synthesizing thereof, and an organic electroluminescent device. The material includes a raw material containing a first group, a raw material containing a second group, and 3,3′-dibromo-1,5,1′,5′-tetramethyl-1,2,4,5-homotetradecene. The thermally activated delayed fluorescent monomolecular white light material synthesis method comprises: a first mixed solution preparation step, a first extraction step, a second mixed solution preparation step, and a second extraction step. A light emitting layer of the organic electroluminescent device includes the thermally activated delayed fluorescent monomolecular white light material.

A method of preparing a hydrogel product including crosslinked glycosaminoglycan molecules, said method including: i) providing a glycosaminoglycan crosslinked by amide bonds, wherein the crosslinked glycosaminoglycans include residual amine groups; and ii) acylating residual amine groups of the crosslinked glycosaminoglycans provided in i) to form acylated crosslinked glycosaminoglycans.

The invention relates to a hydrogel product comprising glycosaminoglycan molecules as the swellable polymer, wherein the glycosaminoglycan molecules are covalently crosslinked via crosslinks comprising a spacer group selected from the group consisting of di-, tri-, tetra-, and oligosaccharides.

This disclosure provides modulators of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR), pharmaceutical compositions containing at least one such modulator, methods of treatment of cystic fibrosis using such modulators and pharmaceutical compositions, and processes for making such modulators.

Disclosed herein, inter alia, are silicon containing detectable compounds and methods of use thereof.

The present invention relates to a chain transfer agent including an organozinc compound, a preparation method thereof, and a method for preparing a block copolymer using the same. A chain transfer agent prepared by a preparation method including preparing a Grignard reagent containing styrene residues, and reacting the prepared Grignard reagent with alkyl zinc alkoxide, which is a zinc compound, has not catalyst poison and by-products, and contains 96 wt % or more of a target compound. A block copolymer polymerized using the chain transfer agent and a resin composition including the block copolymer have excellent mechanical properties.