C07F9/5333

Ophthalmic lens material and ophthalmic lens of such material

A wetness-retaining ophthalmic lens material comprises an organic monomer, a cross-linking agent, an initiator, a salt, and a solvent. The salt dissolves in the water dissociates a plurality of anions and cations, which bind to water molecules and retard the evaporation of the water molecules, the ophthalmic lens material thus can keep wet for a long time. An ophthalmic lens made of the ophthalmic lens material is also provided.

OPHTHALMIC LENS MATERIAL AND OPHTHALMIC LENS OF SUCH MATERIAL
20180210114 · 2018-07-26 ·

A wetness-retaining ophthalmic lens material comprises an organic monomer, a cross-linking agent, an initiator, a salt, and a solvent. The salt dissolves in the water dissociates a plurality of anions and cations, which bind to water molecules and retard the evaporation of the water molecules, the ophthalmic lens material thus can keep wet for a long time. An ophthalmic lens made of the ophthalmic lens material is also provided.

APOL1 INHIBITORS AND METHODS OF USE

Provided herein are compounds of formula (II):

##STR00001##

or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing, wherein wherein m, n, p, R.sup.1, R.sup.2, R.sup.3, L.sup.1, L.sup.2, L.sup.3, R.sup.4, X.sup.1, X.sup.2, X.sup.3, and X.sup.4 are as defined herein. Also provided are methods of preparing compounds of formula (II), or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing. Also provided are methods of inhibiting APOL1 and methods of treating an APOL1-mediated disease, disorder, or condition in an individual.

Phosphorus containing flame retardants

Certain phosphonic acid salts heated at temperatures over 200 C. generate thermally stable, highly efficient flame retardant materials well suited for use as flame retardant additives in polymers. Various methods for preparing flame retardant materials from more than one phosphonic acid salts are provided, wherein each method can generate different flame retardant materials from the same mixture of starting phosphonic acids. The flame retardants of the invention can be used as the sole flame retardant in a composition or in combination with other flame retardants, synergists or adjuvants.

APOL1 inhibitors and methods of use

Provided herein are compounds of formula (II): ##STR00001## or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing, wherein wherein m, n, p, R.sup.1, R.sup.2, R.sup.3, L.sup.1, L.sup.2, L.sup.3, R.sup.4, X.sup.1, X.sup.2, X.sup.3, and X.sup.4 are as defined herein. Also provided are methods of preparing compounds of formula (II), or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing. Also provided are methods of inhibiting APOL1 and methods of treating an APOL1-mediated disease, disorder, or condition in an individual.

Heterocyclic compound and organic light-emitting device comprising same

The present specification relates to a heterocyclic compound represented by Chemical Formula 1, and an organic light emitting device including the same.

APOL1 INHIBITORS AND METHODS OF USE

Provided herein are compounds of formula (II):

##STR00001##

or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing, wherein wherein m, n, p, R.sup.1, R.sup.2, R.sup.3, L.sup.1, L.sup.2, L.sup.3, R.sup.4, X.sup.1, X.sup.2, X.sup.3, and X.sup.4 are as defined herein. Also provided are methods of preparing compounds of formula (II), or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing. Also provided are methods of inhibiting APOL1 and methods of treating an APOL1-mediated disease, disorder, or condition in an individual.

Electron injection layer for an organic light-emitting diode (OLED)

The invention relates to Organic light emitting diode comprising at least one emission layer, an electron injection layer and at least one cathode electrode, wherein: the electron injection layer comprises an organic phosphine compound, wherein the electron injection layer is free of a metal, metal salt, metal complex and metal organic compound; the cathode electrode comprises at least a first cathode electrode layer, wherein the first cathode electrode layer comprises a first zero-valent metal selected from the group comprising alkali metal, alkaline earth metal, rare earth metal and/or a group 3 transition metal; and the electron injection layer is arranged in direct contact to the first cathode electrode layer.