Patent classifications
C07F9/58
PHOSPHOROUS DERIVATIVES AS KINASE INHIBITORS
The invention features compounds of the general formula (I) in which the variable groups are as defined herein, and to their preparation and use.
##STR00001##
PHOSPHOROUS DERIVATIVES AS KINASE INHIBITORS
The invention features compounds of the general formula (I) in which the variable groups are as defined herein, and to their preparation and use.
##STR00001##
A PROCESS FOR THE PREPARATION OF NUCLEOSIDE PHOSPHORAMIDATE
The present invention pertains to process for preparing nucleoside phosphoramidate and its intermediate. The present invention provides novel intermediate, its process for preparation and its use for the preparation of Sofosbuvir.
A PROCESS FOR THE PREPARATION OF NUCLEOSIDE PHOSPHORAMIDATE
The present invention pertains to process for preparing nucleoside phosphoramidate and its intermediate. The present invention provides novel intermediate, its process for preparation and its use for the preparation of Sofosbuvir.
N-[1-((6-chloropyridin-3-yl)methyl)pyridin-2(1H)-ylidene]-2,2,2-trifluoroacetamide for control of agricultural/horticultural pests
A compound of formula (Ie′): ##STR00001##
wherein Ar′, R.sub.1, R.sub.4e and Y are as defined herein and a method of controlling pests using the compound.
N-[1-((6-chloropyridin-3-yl)methyl)pyridin-2(1H)-ylidene]-2,2,2-trifluoroacetamide for control of agricultural/horticultural pests
A compound of formula (Ie′): ##STR00001##
wherein Ar′, R.sub.1, R.sub.4e and Y are as defined herein and a method of controlling pests using the compound.
Oxidized lipids
The present invention is directed to oxidized lipids and pharmaceutical compositions comprising the same. The present invention is also directed to methods of making an oxidized lipid of the invention and to methods of treating or preventing fibrosis or inflammatory diseases or disorders comprising an oxidized lipid of the invention.
Oxidized lipids
The present invention is directed to oxidized lipids and pharmaceutical compositions comprising the same. The present invention is also directed to methods of making an oxidized lipid of the invention and to methods of treating or preventing fibrosis or inflammatory diseases or disorders comprising an oxidized lipid of the invention.
Asymmetrical hydrogenation reaction of ketonic acid compound
The present invention relates to the technical field of organic chemistry, specifically an asymmetrical hydrogenation of an ∂-ketonic acid compound, the technical proposal being as shown by the following formula:
##STR00001##
Wherein R.sup.1 is a phenyl, a substituted phenyl, a naphthyl a substituted naphthyl, a C.sub.1-C.sub.6 alkyl or aralkyl, the substitute is a C.sub.1-C.sub.6 alkyl, a C.sub.1-C.sub.6 alkoxy, a halogen, the number of the substituents is 1-3.
M is a chiral spiro-pyridyl amido phosphine ligand iridium complex having the following structure,
##STR00002##
Wherein, R is hydrogen, 3-methyl, 4-.sup.tBu or 6-methyl
METHODS FOR THE SAFE ADMINISTRATION OF IMIDAZOLE OR IMIDAZOLIUM COMPOUNDS
Methods for the safe administration of imidazole or imidazolium compounds such as zoledronic acid, and conditions that may be treated by these methods, are described herein.