Compositions and methods for inhibiting and interrupting biofilm formation, and for destabilizing established biofilms are provided, the novel compositions including polymeric resins and monomeric non-polymerizable and polymerizable resins. More particularly, the compositions and methods enable the protection and removal of biofilms from surfaces in the context of medical, consumer, domestic, food service, environmental and industrial applications, where the effects constitute beneficial and desirable biofilm attenuating activity.

An intrauterine device and method of delivering and using same are provided. The intrauterine device includes a wire having a portion capable of forming a three dimensional (3D) structure. The 3D structure is elastically deformable to a partially collapsed configuration via a crush force larger than a force applied thereto by a relaxed uterine cavity. The three dimensional structure is also capable of elastically contracting and expanding in response to contraction and expansion of the uterine cavity.

An intrauterine device and method of delivering and using same are provided. The intrauterine device includes a wire having a portion capable of forming a three dimensional (3D) structure. The 3D structure is elastically deformable to a partially collapsed configuration via a crush force larger than a force applied thereto by a relaxed uterine cavity. The three dimensional structure is also capable of elastically contracting and expanding in response to contraction and expansion of the uterine cavity.

An automatic loader and packager station inserts and packages sensitive silicone vaginal rings into sealable pouches, wherein the silicone material is malleable, viscous and sticky, making it hard to accurately insert and seal the rings in a medically sealed package. The circular vaginal rings are axially elongated to reduce their width into the loading position, for accurate loading into scalable package pouches, without contamination of exterior openings of the respective package pouches into which the vaginal rings are inserted for sealed distribution. To accommodate malleable, viscous and/or sticky vaginal rings from manufacture to insertion into sealable pouches, the vaginal rings are moved upon a low friction, preferably roller-based conveyor before being loaded into the sealable pouches.

An automatic loader and packager station inserts and packages sensitive silicone vaginal rings into sealable pouches, wherein the silicone material is malleable, viscous and sticky, making it hard to accurately insert and seal the rings in a medically sealed package. The circular vaginal rings are axially elongated to reduce their width into the loading position, for accurate loading into scalable package pouches, without contamination of exterior openings of the respective package pouches into which the vaginal rings are inserted for sealed distribution. To accommodate malleable, viscous and/or sticky vaginal rings from manufacture to insertion into sealable pouches, the vaginal rings are moved upon a low friction, preferably roller-based conveyor before being loaded into the sealable pouches.

An intrauterine device (20) with a restricted movement of a knot (5) of the string (4) due to a region (3) having such differed shape and size at a distal end (12) of central vertical stem (1) and due to a trajectory for string (4) in the region (3) that the length of the string (S) is shorter than the distance (r) of the region (3); and the loop (15) of the string and therefore the knot (5) is unable to pivot around the axis (14). The lateral shift of the knot (5) is also prevented. Consequent to restricted pivoting and restricted lateral shift of the knot (5), the hanging portion (9) of the string (4) continue to project downwards and do NOT develop tendency to get retracted and thus do not curl up in the uterus (16) through the cervix (17).

The present invention provides intravaginal drug delivery devices, such as intravaginal rings, comprising active pharmaceutical ingredients (APIs) having terminal alkene, alkyne or carbonyl functionalities. The devices of the invention exhibit increased recovery of the active pharmaceutical ingredient from platinum-catalyzed silicone polymers due to the optimization of drug particle size and cure conditions. The present invention also provides methods of preventing unintended pregnancy in a female human, methods of preventing unintended pregnancy in a female human and HIV infection in a female human, and methods of preparing intravaginal drug delivery devices.

The invention relates to an inserter for an intrauterine system, comprising a handle (3) having a longitudinal opening (8) at its first end, said opening (8) having a longitudinal axis parallel to the longitudinal axis of the inserter, a first end (8a) and a second end (8b), a moveable slider (5) arranged in said longitudinal opening (8) and having a first end (5a) and a second end (5b), a plunger (2) attached to the handle (3), an insertion tube (6) arranged around the plunder (2) having a first end and a second end, with its second end attached to the slider (5), wherein the inserter further comprises locking means for reversibly locking the intrauterine system in relation to the plunder (2) via a removal string of the intrauterine system, said locking means being controllable by the slider (5) and/or the insertion tube (6).

Disclosed are two-handed IUD insertion devices for positioning an intrauterine device (IUD) in the uterus which includes a plunger, a sheath, a grip and a handle where the axial movement of the plunger is controlled via features along the length of the plunger in communication with a grip feature.

Described herein is an intravaginal drug delivery system. In an embodiment the intravaginal drug delivery system includes a progestin and estrogen compound, and releases the active ingredients in a fixed physiological ratio over a prolonged period of time to produce a contraceptive state in a female.