A water-based composition of the present disclosure includes a metal pigment, a polyoxyalkylene amine compound, and a water-based medium, in which the metal pigment is formed of a plurality of metal particles, the metal particles are surface-modified by a surface treatment agent, and a content of the polyoxyalkylene amine compound is 0.1 parts by mass or more and 50 parts by mass or less with respect to 100 parts by mass of the metal particles.

A rubber composition based at least on a reinforcing filler comprising a content of silica of greater than or equal to 80 phr and on an elastomer matrix comprising a content of a modified diene elastomer of greater than or equal to 75 phr is provided. The modified diene elastomer includes macromolecules comprising, within their structure, a linear or branched polyether block comprising, at each of the two ends of the block, a branch point to which up to three diene elastomer branches and up to three —OR groups are bonded, R representing, independently of one another, a C.sub.1-C.sub.8 alkyl substituent or a hydrogen atom

b—the. The copolymer is composed: of at least 20% of branched macromolecules comprising a polyether block to which at least three diene elastomer blocks are bonded, of at most 80% of linear macromolecules, and
d—each of the branch points includes a silicon atom.

The present invention provides an aqueous pigment dispersion liquid being such that a pigment is finely dispersed, and the viscosity, and the particle diameters of the pigment are unlikely to fluctuate, being excellent in storage stability, and enabling preparation of an emulsion-polymerized toner having properly controlled particle diameters while improving the pigment utilization rate. The aqueous pigment dispersion liquid is an aqueous pigment dispersion liquid for an emulsion-polymerized toner containing a pigment, a dispersant, and an aqueous medium. The dispersant is a polymer containing a constitutional unit (A) derived from a monomer (A) such that a group containing a (meth)acryloyloxy group or the like is bonded to one end of a particular polyethylene glycol chain or the like, and a constitutional unit (B) derived from a monomer (B) having a carboxy group or the like, the polymer has a number average molecular weight in terms of polystyrene of 4,000 to 15,000, as measured by gel permeation chromatography, the polymer is contained in a state of being not ionized substantially, and the aqueous pigment dispersion liquid has a pH of 3.0 to 8.4.

The disclosure relates to oxamate esters and formulations made therefrom, and to methods of making both the oxamate esters and the formulations.

A surface-treating agent including a component (A) which is at least one fluoropolyether group-containing compound of formula (1A) or (2A) shown below; a component (B) which is at least one fluoropolyether group-containing compound of the following formula (1B) or (2B) shown below; and a component (C) which is one or more fluorine-containing oils:

Rf.sup.1A.sub.α1—X.sup.A—R.sup.A.sub.β1  (1A)

R.sup.A.sub.γ1—X.sup.A—Rf.sup.2A—X.sup.A—R.sup.A.sub.γ1  (2A)

Rf.sup.1B.sub.α2—X.sup.B—R.sup.B.sub.β2  (1B)

R.sup.B.sub.γ2—X.sup.B—Rf.sup.2B—X.sup.B—R.sup.B.sub.γ2  (2B)

wherein formulas (1A), (2A), (1B and (2B) are as defined herein.

A PEG linker as represented by formula (I), wherein n and m are respectively an integer from 1 to 7, providing the PEG linker with 1 to 49 linking sites. A ligand drug conjugate as represented by formula (II). The conjugate uses the PEG linker to increase a drug loading capacity and drug loading diversity, thereby improving pharmaceutical efficacy.
Y1-PEG1-{R.sup.1-PEG2-{Y4}.sub.n}.sub.m  (I)
TM-{R.sup.2-PEG1-{R.sup.1-PEG2-{R.sup.3-A′-drug}.sub.n}.sub.m}.sub.l  (II)

The present disclosure generally relates to a multifunctional additive obtained from the reaction of: (a) an intermediate obtained from the reaction of maleic anhydride and a polyoxyalkylene monoamine; and (b) an amine compound comprising a primary amine group and/or a secondary amine group and its use in a variety of applications, including, but not limited to: as a corrosion inhibitor or friction modifier in aqueous and non-aqueous systems; in fuel deposit control agents; as a dispersant in pigment, asphalt and cement compositions; and as a detergent.

The compounds disclosed herein (e.g., compounds of Formula (I), (II), (III), and (IV)) comprise a lipid substructure comprising a hydrophobic moiety and a hydrophilic moiety; and two or more polymeric groups (e.g., two or more polyethylene glycol (PEG) groups). The compounds provided herein can be useful for delivery and expression of mRNA and encoded protein, e.g., as a component of liposomal delivery vehicle, and accordingly can be useful for treating various diseases, disorders and conditions, such as those associated with deficiency of one or more proteins.

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The present invention provides an aqueous pigment dispersion liquid being such that a pigment is finely dispersed, and the viscosity, and the particle diameters of the pigment are unlikely to fluctuate, being excellent in storage stability, and enabling preparation of an emulsion-polymerized toner having properly controlled particle diameters while improving the pigment utilization rate. The aqueous pigment dispersion liquid is an aqueous pigment dispersion liquid for an emulsion-polymerized toner containing a pigment, a dispersant, and an aqueous medium. The dispersant is a polymer containing a constitutional unit (A) derived from a monomer (A) such that a group containing a (meth)acryloyloxy group or the like is bonded to one end of a particular polyethylene glycol chain or the like, and a constitutional unit (B) derived from a monomer (B) having a carboxy group or the like, the polymer has a number average molecular weight in terms of polystyrene of 4,000 to 15,000, as measured by gel permeation chromatography, the polymer is contained in a state of being not ionized substantially, and the aqueous pigment dispersion liquid has a pH of 3.0 to 8.4.

Compounds of formula I: or a pharmaceutically acceptable salt, hydrate, and/or solvate thereof, wherein: R.sub.1 is a pharmaceutically acceptable polymeric moiety comprising a pharmaceutically acceptable polymer chain such that the carbonyl group is linked to R.sub.1 through an ester, amide, carbonate or carbamate bond; R.sub.2 is hydrogen, or —(C═O)Rs wherein R.sub.5 is a C.sub.1-3 straight or branched chain alkyl group; and R.sub.3 and R.sub.4 are independently selected from hydrogen, C.sub.1-3 straight or branched chain alkyl group, or —(C=0)Re wherein R.sub.6 is —(O—CH.sub.2—CH.sub.2).sub.n—OCH.sub.3 or a C1-3 straight or branched chain alkyl group, and n is 1 to 5. The compositions are useful for the treatment of Parkinson's disease when administered alone or in combination with carbidopa and/or entacapone.

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