A lipid derivative in which a hydrophilic polymer is bound through a cyclic benzylidene acetal linker, and which can accurately control a hydrolysis rate in the weakly acidic environment of a living body to detach the hydrophilic polymer from a lipid membrane structure. The lipid derivative is represented by formula (1):

##STR00001##

wherein, R.sup.1 and R.sup.6 are each independently a hydrogen atom or a hydrocarbon group; R.sup.2, R.sup.3, R.sup.4 and R.sup.5 are each independently an electron-withdrawing or electron-donating substituent or a hydrogen atom; R.sup.7 is a hydrocarbon group having from 8 to 24 carbon atoms, an acyl group having from 8 to 24 carbon atoms, a cholesterol derivative, a glycerolipid, a phospholipid or a sphingolipid; P is a hydrophilic polymer; s is 1 or 2, t is 0 or 1, and s+t is 1 or 2; and Z.sup.1 and Z.sup.2 are each independently a selected divalent spacer.

The present disclosure is directed to fatty-acid glycerol ester derivative compounds containing a targeting bisphosphonate group. The disclosure further include pharmaceutical or biomedical compositions comprising these compounds, and methods of using these compounds and compositions forming microbubbles. The microbubbles have affinity for metal-containing, especially calcium-containing, bodies and/or biological targets. In certain embodiments, these compositions are useful for providing targeted placement of microbubbles capable of cavitation on application of high frequency energy.

This disclosure provides improved lipid-based compositions, including lipid nanoparticle compositions, and methods of use thereof for delivering agents in vivo including nucleic acids and proteins. These compositions are not subject to accelerated blood clearance and they have an improved toxicity profile in vivo.

A polymeric amine synergist is disclosed herein. An example of the polymeric amine synergist includes an aniline moiety, a polyethylene glycol chain, and an ether linkage attaching one end of the polyethylene glycol chain to the aniline moiety. The polymeric amine synergist may be included in a photo curable ink composition.

The invention relates to dispersants for inorganic particles, preferably for hydraulic binders, which comprises the following structural units: i) at least one triazine structural unit, ii) at least one polyalkylene glycol structural unit, and iii) at least two phosphoric ester structural units on at least one carbon atom of one or more aromatic triazine rings of the formulae (IIa) and/or (IIb):
N(CH.sub.2CH.sub.2OPO.sub.3H.sub.2).sub.2,(IIa)
and
NHCH.sub.2CH.sub.2OPO.sub.3H.sub.2.(IIb) The invention also relates to a process for preparing the dispersants, to building material mixtures comprising one or more dispersants and one or more inorganic binders. The invention relates to the use of the dispersants as a water reducing agent, as a means for reducing the viscosity and for enhancing the early strengths of aqueous inorganic binders, and also to the use as a grinding aid in the production of cement.

The present disclosure is drawn to polymeric amine synergist compositions. The polymeric amine synergist composition can include a polymeric amine synergist including an aminobenzene modified with a polyether chain connecting to the aminobenzene through an ether linkage. The polymeric amine synergist can be present in a reaction product mixture with either i) an aminophenol, or ii) a carbonate base.

A method of manufacturing cyclophosphazenes PFPE derivatives to be used in the lubrication of magnetic recording media is herein provided. The method comprises: a) a (per)fluoropolyether (PFPE) polyol [PFPE (P.sub.pol)] comprising a fluoropolyoxyalkylene chain (R.sub.f) having two chain ends, each chain end comprising at least one hydroxy group, and b) the corresponding alkoxide of perfluoropolyether (P.sub.pol) [PFPE (P.sub.alk)] wherein the equivalent concentration of PFPE (P.sub.alk) in PFPE (P.sub.pol) is lower than 30%, preferably ranging from 5% to 15%; 2) contacting mixture (M) with a perhalocyclophosphazene (CP.sub.halo) to provide a mixture (M1) containing an equivalent ratio of PFPE (P.sub.alk)/(CP.sub.halo) of at least 1; 3) allowing mixture (M1) to react until complete disappearance of PCl groups to provide a mixture (M2); 4) submitting mixture (M2) to hydrolysis to provide a mixture (M3); 5) optionally removing (P.sub.pol) from mixture (M3) to provide a mixture (M4). A method of purifying mixture (M4) is also herein provided.

This disclosure provides improved lipid-based compositions, including lipid nanoparticle compositions, and methods of use thereof for delivering agents in vivo including nucleic acids and proteins. These compositions are not subject to accelerated blood clearance and they have an improved toxicity profile in vivo.

Methods are provided for the preparation of conjugates of a variety of bioactive components, especially proteins, with water-soluble polymers (e.g., poly(ethylene glycol) and derivatives thereof), which conjugates have reduced antigenicity and immunogenicity compared to similar conjugates prepared using poly(ethylene glycol) containing a methoxyl or another alkoxyl group. The invention also provides conjugates prepared by such methods, compositions comprising such conjugates, kits containing such conjugates or compositions and methods of use of the conjugates and compositions in diagnostic and therapeutic protocols.

Compounds useful as fluorescent or colored dyes are disclosed. The compounds have the following structure (I): (I) or a stereoisomer, tautomer or salt thereof, wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, L.sup.1, L.sup.1a, L.sup.1b, L.sup.2, L.sup.3, L.sup.4, L.sup.5, L.sup.6, L.sup.7, M.sup.1, M.sup.2, m, n, q, and w are as defined herein. Methods associated with preparation and use of such compounds are also provided.