Apparatus for cooling an object, space, or tissues of a patient. A vacuum chamber is designed to be placed in thermal contact with the object or space to be cooled, or against a patient to be treated. A water sprayer is configured to spray water into the vacuum chamber or against a cooling wall of the chamber. A vacuum pump and control are designed to maintain vacuum below ambient pressure in the vacuum chamber sufficient to cause accelerated evaporation of the water and cooling to a temperature desired for cooling of the object, space, or patient.

A method in accordance with a particular embodiment of the present invention includes increasing a concentration of a modified or unmodified saccharide within a subject's skin, applying an applicator to the subject's skin, and cooling the subject's skin via a heat-transfer surface of the applicator. The saccharide within the subject's skin can enhance a resistance of at least some cells within the subject's skin to damage associated with the cooling. A corresponding system includes the applicator, the saccharide, and an energy-delivery device. The energy-delivery device can be configured to apply ultrasound, optical, thermal, or another type of energy to the subject's skin to drive the saccharide into the subject's skin. The system can also include a penetration enhancer configured to enhance penetration of the saccharide into the subject's skin. The penetration enhancer can be applied with the saccharide or separately.

This disclosure relates generally to a system and method for the delivery of cooled air selectably using a device with removable component which directs cooled air to a desired area at or near the hair of a subject. The device may have one or more components which may be quickly and easily removed and replaced.

A dressing system for cooling skin or a wound site on a subject comprises a dressing having a reservoir for holding a liquid. The dressing may be configured for placement proximate to a postoperative surgical wound site of the subject or on the facial area of the subject. The dressing system includes a cooling chamber external to the dressing configured to cool the liquid. The dressing system includes a pump configured to circulate the liquid between the cooling chamber and the reservoir. The dressing system may include a suction element for applying suction at, or proximate to, the dressing for removing sweat or wound drainage.

Systems and methods for generating user-specific recommendations of products or services by collaborative filtering executed and/or performed by one or more trained or untrained predictive models configured to ingest product attribute(s), product purpose(s), user location data, and/or user demographics. The predictive model(s) are leveraged to detect and determine user-specific preferences for, and preferences against, particular attributes, features, ingredients, aesthetic styles, and so on.

A device comprising a heat-generating component that comprises an alkali metal is provided. The alkali metal in the presence of water at a point of contact of the device undergoes an exothermic reaction to generate heat in situ. The amount of heat generated is proportional to and/or limited by the amount (or moles) of water at the point of contact, and the heat generated is sufficient to achieve an increase in temperature at the point of contact to achieve a therapeutic or beneficial result. In one embodiment, the device is used for reducing sweat production in a subject suffering from excessive sweating or hyperhidrosis. In other embodiments, the device is used to substantially sterilize a surface or render a surface substantially aseptic.

A transparent cover member for a skin treatment device passes light and heat to a user's skin. The transparent cover member presents a comfortable flat surface at its exterior, and includes features that couple to a heating element that surrounds a plurality of visible light LEDs. The transparent cover member can include retaining features to assist in assembling the head assembly of the skin treatment device.

A cooling device for removing heat from subcutaneous lipid-rich cells of a subject having skin is provided. The cooling device includes a plurality of cooling elements movable relative to each other to conform to the contour's of the subject's skin. The cooling elements have a plurality of controllable thermoelectric coolers. The cooling elements can be controlled to provide a time-varying cooling profile in a predetermined sequence, can be controlled to provide a spatial cooling profile in a selected pattern, or can be adjusted to maintain constant process parameters, or can be controlled to provide a combination thereof.

A skin treatment device especially for use for treating skin in terms of cleaning, exfoliating and/or massaging the skin. The device includes a housing and a skin treatment head releasably attached to the housing. The skin treatment head being rotatable around an axis element associated with the housing, wherein the housing encloses an actuator configured to rotate the skin treatment head, wherein the skin treatment head includes one or more brushes associated with a support element, wherein the device further includes a first thermally conductive element configured at a shortest distance to the one or more brushes selected from the range of 0-40 mm, and a thermoelectric element configured to heat in a first mode the first thermally conductive element to provide a hot surface.

Applicator (3) for cold treatment, comprising an applicator housing (5) with an inlet opening (18) and a leak tight tip (23). The applicator housing (5) encloses a channel body (20) extending between the inlet opening (18) and the leak tight tip (23). The applicator (3) is mounted or mountable in a releasable manner onto a pressurized dispenser (2) comprising a nozzle (7), such that the inlet opening (18) is in fluid communication with the nozzle (7). The applicator housing (5) is moveable between a rest position and a pressed position to activate the nozzle (7). The applicator housing (5) has release openings (26) which are closed in the pressed position.