Medical devices, systems, and methods for pain management and other applications may apply cooling with at least one probe inserted through an exposed skin surface of skin. The cooling may remodel one or more target tissues so as to effect a desired change in composition of the target tissue and/or a change in its behavior, often to interfere with transmission of pain signals along sensory nerves. Alternative embodiments may interfere with the function of motor nerves, the function of contractile muscles, and/or some other tissue included in the contractile function chain so as to inhibit muscle contraction and thereby alleviate associated pain. In some embodiments, other sources of pain such as components of the spine (optionally including herniated disks) may be treated.

A medical device providing a combination of thermal and DVT therapies to a patient. The components, arrangement of components, function of the device as a whole, and methods of use of the device are all devised to maximize therapeutic effectiveness. Effectiveness in this context is measured by the ability to provide a controlled application of the recommended thermal treatment including time, temperature, compression, and number of cycles with specified cycle duration.

A therapeutic sleeve and techniques for using it are provided. A therapeutic sleeve may house a conduit carrying a constant stream of a chilled or heated working fluid throughout the sleeve. A heating element may evenly distribute heat throughout the sleeve. The sleeve may provide a precise temperature-controlled pocket that significantly improves treatment of pain or discomfort in the user's feet, head, or other body parts. A software application may enable a user to set or adjust a temperature, set timers, record sleep patterns, and view analytics or other data.

The invention is directed to a mouth piece for cooling of oral tissue of a patient during chemotherapy treatment. The mouth piece includes a cooling medium contained within the top element and the bottom element and able to retain a cooling environment within the mouth sufficient to reduce capillary blood flow to the patient's mouth.

The invention relates to a device for use in the thermal therapy treatment of a selected region of the body of a human or of an animal, in particular for use in the treatment of tissue damage after surgical interventions, of injuries, of inflammations and of chronic diseases of the rheumatic type, and in particular for assisting chemotherapeutic treatments, comprising a temperature control device which is provided in order to control a temperature of a temperature control fluid, and a heat transfer device which is arranged to transfer heat to the selected region of the body, wherein the temperature control device is connected, in a fluid conducting manner, to the heat transfer device, and is further arranged to temper the heat transfer device with a heat transferring temperature control fluid flowing through the heat transfer device, and with a control device which is connected to the temperature control device and to the heat transfer device, wherein the control device is arranged to control the temperature control device, in order to cause the heat transfer device to be at least partially at an approximately uniform temperature in the region of a contact surface between the heat transfer device and the selected region of the body to be temperature controlled. The invention further relates to a method of operating the device.

A fat-reducing treatment device and a freezing fat-reducing instrument are disclosed. The fat-reducing treatment device includes at least two concave cups (100), each concave cup (100) having a trough-shaped body (110) and a connecting end (120). The at least two concave cups (100) are coupled together at the connecting ends (120) such as to rotatable about a first axis (A). The trough-shaped bodies (110) of the at least two concave cups (100) are brought into communication with each other at the connecting ends (120). The first axis (A) is oriented in a first direction, and the trough-shaped bodies (110) extend in a second direction (B) and are open in a third direction. With this arrangement, the trough-shaped bodies (110) can accommodate the placement of a larger abdomen or waist portion of a human body. In this way, the trough-shaped bodies (110) can adapt to waist and abdomen portions with different contours and curvatures and provide a large fat reduction treatment area, resulting in a simpler treatment procedure, a shorter treatment time, higher fat reduction efficiency, improved fat reduction outcomes and enhanced user experiences and satisfaction.

The described apparatuses, devices, and mechanisms are configured to measure the temperature of one or more Abreu brain thermal tunnel (ABTT) terminuses. In addition, some embodiments are configured to provide treatment for the diagnosed conditions and diseases.

A system for cooling or heating a body part includes at least one bladder, a pump, a heat exchanger, a first fluid line in fluid communication with the heat exchanger and the at least one bladder, a second fluid line in fluid communication with the at least one bladder and the heat exchanger, a main reservoir and a separator. The heat exchanger is in fluid communication with the pump. The first fluid line is located downstream from the heat exchanger and the second fluid line is located downstream from the at least one bladder when the system is operating to cool or heat the body part. The separator is in fluid communication with the main reservoir and the pump and is located below the main reservoir to receive fluid under the influence of gravity from the main reservoir and to deliver fluid to the pump via gravity.

Disclosed are methods of obtaining zero vergence ultrasound waves for providing sonodynamic therapy with ultrasound waves. The method includes coupling a sonodynamic therapy device with an array of flat piezoelectric transducers to a skin surface. A controller is configured to generate an electrical drive signal at a frequency, modulate the drive signal, and drive the transducer with the modulated drive signal at the frequency to produce a zero vergence ultrasound wave to produce an average acoustic intensity sufficient to activate a sonosensitizer in a treatment region without damaging healthy cells in the treatment region.

Methods of treating tumors by administering compounds to a patient are provided. Compounds such as pro drugs, e.g., 5-aminolevulinic acid (5-ALA), may be administered to the patient orally, by injection, intravenously, or topically, which then accumulate preferentially as compounds such as protoporphyrin IX (PpIX) in tumor cells. After such accumulation, compounds such as PpIX are then activated in various aspects to treat tumors cells, thereby treating cancer. Cancers such as glioblastoma may be treated.