An improved medical pad for contact thermal exchange with a patient includes a fluid circulation layer for containing a thermal exchange fluid circulatable therethrough, a first port and a second port for circulating the thermal exchange fluid in to and out of the fluid circulation layer, and a hydrogel layer interconnected to and extending across one side of the fluid circulation layer to define an adhesive surface for adherence to a patient's skin. The hydrogel layer can include an ultraviolet light-cured composition with a cross-linking copolymer, water, and glycerol. The hydrogel layer is provided to have a thermal conductivity of at least about 1.9 ca//hr-cm-° C.

A therapeutic cooling and/or compression system, configured to cool a body portion, comprises a conformal covering for covering the body portion configured to extract heat energy from the body portion, a sensor device within the conformal covering for sensing a parameter of the body portion, an actuator configured for changing an amount of heat energy extracted from the body portion, and a control unit configured for regulating the actuator responsive to control input from the sensor device. The system may be portable, enabling a patient to walk while undergoing treatment.

Devices, systems, and methods herein relate to cooling a head of a patient. These systems and methods may comprise a cooling cap assembly comprising a heat exchanger configured to be wrapped around a head of a patient and a compression assembly releasably coupled to the heat exchanger. The compression assembly may comprise an enclosure and an inflatable member coupled to an internal surface of the enclosure. When coupled, the inflatable member may be positioned between the enclosure and the heat exchanger. The heat exchanger may be separate from and moveable relative to the inflatable member.

A mobile, self-contained cold therapy device having a container including an internal liquid or ice water tank, air and water pumps for driving air and water to a cold therapy pad with internal air and water bladders, wherein the pad is worn on an injured region of a user. The device includes an electronic controller for controlling air and water flow to and from the bladders, and a holder for supporting the container and worn on the user's body for portable, hands-free mobility while receiving cold therapy. Nipples are incorporated into a thermal conduction surface of the pad and reciprocated into the user's injured region by an air bladder to further reduce edema.

A cold compress circulation device and a cold compress circulation system are disclosed. The cold compress circulation device includes a casing, a water reservoir, a cooler, an outlet pipe, a return pipe and an ice box. Both the water reservoir and the cooler are arranged in the casing, and at least part of the ice box is detachably arranged in the water reservoir. Both the outlet pipe and the return pipe are brought into fluidic communication with the water reservoir, and the cooler is arranged on the outlet pipe and/or the return pipe. In this arrangement, the detachable ice box serves as a means for accelerated cooling and can be conveniently replaced by a user. Moreover, the ice box does not lead to an increased amount of water to be circulated or release small ice piece when heated, which may lead to reduced cooling efficiency. Thus, both enhanced cooling efficiency and increased convenience of use are achieved for the user.

An intravital cooling device is for cooling a target site in a living body and includes: a heat exchange part having a flow channel through which a refrigerant passes; and a flexible heat conduction sheet that is directly or indirectly connected to the heat exchange part and arranged to cover the target site, wherein the heat conduction sheet includes a living-body surface, which is a surface on the side that makes contact with the target site, and an outer surface, which is a surface opposite from the living-body surface.

A method is provided for in-situ cooling of biological tissue within the body, the biological tissue being selected from the group consisting of organ tissue, blood vessel tissue and combinations thereof. The method comprises establishing a heat-conducting contact between a heat absorption zone of a cooling unit of a device for in-situ cooling of biological tissue and the biological tissue within the body, transporting thermal energy from the heat absorption zone of the cooling unit via a substance for transporting thermal energy, which is arranged within a hollow tube of the device for in-situ cooling of biological tissue, to a cooling device of the device for in-situ cooling of biological tissue, and releasing the thermal energy via the cooling device. The method allows protecting biological tissue within the body in a location-selective manner from cancer-therapy-caused damage during cancer therapy in a simple, cost-effective and low-risk manner.

In an example, a cryotherapy device includes an elongated shaft, and a cryotherapy delivery member coupled to a distal end of the elongated shaft. The cryotherapy delivery member is configured to apply, from a fixed position in a nasal cavity, thermal energy to at least one of a plurality of nerves in the nasal cavity or a plurality of branches of a nerve in the nasal cavity.

Methods of treating tumors by administering compounds to a patient are provided. Compounds such as pro drugs, e.g., 5-aminolevulinic acid (5-ALA), may be administered to the patient orally, by injection, intravenously, or topically, which then accumulate preferentially as compounds such as protoporphyrin IX (PpIX) in tumor cells. After such accumulation, compounds such as PpIX are then activated in various aspects to treat tumors cells, thereby treating cancer. Cancers such as glioblastoma may be treated.

A temperature management system controls a temperature of a body of a patient and determines a value indicative of a thermoregulatory activity of the patient. The system includes a heat exchange system configured to exchange heat with a body of a patient and to record operational data while controlling the temperature of the body of the patient. The temperature management system receives temperature data from a sensor, controls the heat exchange system to maintain the temperature of the body of the patient within a target temperature range, receives, in response to the controlling, operational data, determines, based on the temperature data and the operational data, a value indicative of a thermoregulatory activity of the patient, and generates, based on the value, an alert through the user interface indicating the thermoregulatory activity of the patient.