Disclosed is a local cooling anesthesia device for spraying a coolant on a treatment site. The local cooling anesthesia device includes a housing which forms an outward form and from which the coolant is sprayed and a spraying unit installed in the housing to spray the coolant. The device also includes a cooling temperature regulator connected to the spraying unit to apply thermal energy to the sprayed coolant for temperature regulation and a control unit connected to the cooling temperature regulator to control the cooling temperature regulator. The cooling anesthesia device has functions of measuring and regulating the temperature of the coolant, and thus can apply the coolant to the treatment site within a safe temperature range according to the purpose of treatment, thereby enabling a desired treatment purpose such as local anesthesia to be safely and rapidly accomplished without side effects such as cytoclasis.

Methods, devices, and systems employ cryolysis of oropharyngeal adipose tissues to selectively remove fat cells from the tissues causing obstructive sleep apnea. In various embodiments, a chilled liquid—e.g., a liquid or air—is applied to the target tissue at a temperature and for a duration sufficient to cause cryolysis.

This application relates to a hand-held cooling device for supplying a cryogen to a target region for cryotherapy. The device can include a cryogen transfer unit configured to receive a first cryogen from an external cryogen reservoir, the first cryogen including i) a first amount of a liquid phase cryogen and ii) at least one of a first solid phase cryogen and a first gas phase cryogen. The device can also include a nozzle configured to spray a first modified cryogen to the target region. The device can further include a cryogen liquefier disposed between the cryogen container and the nozzle and configured to cool the first cryogen received from the cryogen transfer unit and output the first modified cryogen to the nozzle, the first modified cryogen including at least a second amount of the liquid phase cryogen more than the first amount of the liquid phase cryogen.

A cooling sheet is provided. The cooling sheet according to one embodiment of the present invention includes a moisture storage layer which stores therein moisture, an absorbing layer which is fused to one surface of the moisture storage layer to absorb the moisture and is applied with microcapsules containing a functional material, and a water repellent layer which is fused to the other surface of the moisture storage layer to be in contact with skin, prevents the moisture from escaping and absorbs air from outside. Accordingly, it is possible to provide a cooling sensation using heat of evaporation when in contact with skin while preventing moisture from escaping to the outside along seam lines.

Methods of treating viral infections. At least one example embodiment is a method including: measuring a core temperature of a human patient; testing the human for the presence of a virus that causes disease; responsive to the human having both fever and presence of the virus, submerging at least a trunk and legs of the human in water comprising a surfactant, the human at least partially submerged in the water for a treatment period of at least three hours; and controlling a temperature of the water during the treatment period.

A control unit system. The system includes a control unit which includes a control unit charging interface, at least one magnet located proximate to the control unit charging interface, at least one actuator, a detachable manifold including at least one magnet, fluidly coupled to the at least one actuator, a pump connected to the at least one actuator for causing actuation thereof, and a control system for controlling the pump, wherein the control system controls the pump to actuate the at least one actuator at least in response to a signal received by the control system. The system also includes a recharging device configured to receive the control unit, the recharging device including a reed switch, wherein when the magnet in the control unit is located proximate to the reed switch, the switch is activated.

The present invention involves the use of a small profile device for preparation and/or delivery of cold slurry into the human body. The cold slurry can be generated within the device itself or within a separate small chamber, both of which produce a cold slurry using a cooling source and an injectable fluid. The delivery device provides continued agitation to the fluid/slurry through rotation and/or vibration of blades within the device. The fluid/cold slurry is cooled/kept cool through the use of an external cooling device, such as a cooling sleeve, that at least partially surrounds the delivery device. The cooling sleeve can cool or maintain the temperature of the cold slurry through a number of mechanisms. The cold slurry can be delivered using a device in accordance with the present invention to any tissue inside the body, including subcutaneous fat, visceral fat, and brown fat.

Exemplary embodiments of the present disclosure provide method and apparatus for effecting (e.g., lightening) an appearance of skin by cooling or freezing small separated surface regions of the skin to produce regions of local hypopigmentation. The width of the regions can be, for example, smaller than about 1 mm or 0.5 mm, and a distance between these frozen regions can be greater than about 3 times the width of the regions. An exemplary apparatus can be provided that includes a plurality of spatially-separated thermally conductive arrangements that can be affixed or otherwise coupled to a base. For example, the conductive arrangements can be regions of conductive material provided in or proximal to a thermal insulator, or thermally conductive protrusions affixed to the base. The conductive arrangements can be cooled and then contacted with the skin surface to produce the small regions of hypopigmentation.

This application relates to a hand-held cooling device for supplying a cryogen to a target region for cryotherapy. The device can include a cryogen container configured to contain a first cryogen having a first temperature and a nozzle configured to spray a first modified cryogen to the target region, the first modified cryogen having a second temperature higher than the first temperature. The device can also include a cryogen temperature regulator configured to receive the first cryogen and output the first modified cryogen to the nozzle, the cryogen temperature regulator disposed closer to the nozzle than the cryogen container. The cryogen temperature regulator can include a holder tube, a porous structure disposed inside a holder tube and a heater disposed around the holder tube and heating the holder tube so as to increase the first temperature to the second temperature while the first cryogen passes through the porous structure.

Methods for at least partially eradicating a target tissue by apoptosis may include reducing the temperature of a device shaft on a tissue eradication device to a target temperature, vibrating the device shaft and inducing apoptosis in the target tissue by contacting the target tissue with the device shaft or injecting a cold fluid from the cannulated device shaft of the tissue eradication device into the target tissue. Tissue eradication systems are also disclosed.