A hyperthermia implant 20 for hyperthermia treatment of tissue 30 of a human or animal body. The implant comprises at least one piece of a large Barkhausen jump material (LBJ) and a magnetic field may be applied to the implant to heat the surrounding tissue. The implant may also be deployed to mark a tissue site in the body for subsequent surgery, thereby providing a combined system for locating an implant and treating the surrounding area. The system includes a handheld probe 14 to excite the implant below the switching field for bistable switching causing a harmonic response to be generated in a sub-bistable mode that allows the implant to be detected and localised.

A cold compress circulation device and a cold compress circulation system are disclosed. The cold compress circulation device includes a casing, a water reservoir, a cooler, an outlet pipe, a return pipe and an ice box. Both the water reservoir and the cooler are arranged in the casing, and at least part of the ice box is detachably arranged in the water reservoir. Both the outlet pipe and the return pipe are brought into fluidic communication with the water reservoir, and the cooler is arranged on the outlet pipe and/or the return pipe. In this arrangement, the detachable ice box serves as a means for accelerated cooling and can be conveniently replaced by a user. Moreover, the ice box does not lead to an increased amount of water to be circulated or release small ice piece when heated, which may lead to reduced cooling efficiency. Thus, both enhanced cooling efficiency and increased convenience of use are achieved for the user.

Methods of treating tumors by administering compounds to a patient are provided. Compounds such as pro drugs, e.g., 5-aminolevulinic acid (5-ALA), may be administered to the patient orally, by injection, intravenously, or topically, which then accumulate preferentially as compounds such as protoporphyrin IX (PpIX) in tumor cells. After such accumulation, compounds such as PpIX are then activated in various aspects to treat tumors cells, thereby treating cancer. Cancers such as glioblastoma may be treated.

Embodiments include a cryogenic device for alleviating pain by cryogenically treating a nerve, the cryogenic device including a handpiece; a needle coupled to a distal end of the handpiece, the needle including a needle lumen, the needle being configured for insertion into a skin of a patient along an insertion axis at a site laterally displaced from a treatment zone proximate to the nerve. The needle is configured to resiliently bend after insertion away from the insertion axis, such that at least a portion of the needle is adapted to traverse a skin layer laterally toward the treatment zone. The device includes a cooling fluid supply tube extending distally into the needle lumen; and a cooling fluid source, wherein the cooling fluid source is coupled to the cooling fluid supply tube to direct cooling fluid into the needle lumen.

A temperature management system controls a temperature of a body of a patient and determines a value indicative of a thermoregulatory activity of the patient. The system includes a heat exchange system configured to exchange heat with a body of a patient and to record operational data while controlling the temperature of the body of the patient. The temperature management system receives temperature data from a sensor, controls the heat exchange system to maintain the temperature of the body of the patient within a target temperature range, receives, in response to the controlling, operational data, determines, based on the temperature data and the operational data, a value indicative of a thermoregulatory activity of the patient, and generates, based on the value, an alert through the user interface indicating the thermoregulatory activity of the patient.

A bed for therapeutic and recreational applications, comprises a frame structure, a mattress provided on the frame structure of the bed, a plurality of Light Emitting Diodes (LEDs) configured to emit electromagnetic radiation, an infrared heater assembly provided within the frame structure, the infrared heater assembly including a plurality of flexible heating elements connected with a power source, a plurality of temperature sensors provided at a plurality of locations on the frame structure and the mattress in order to generate signals in correlation with temperature values at the plurality of locations. Further, the frame structure includes a plurality of frame segments adapted to rotate to respective predetermined angles. Also, the mattress is made from at least partially transparent material and includes a fluid that is at least partially transparent.

A seating assembly for athletes includes seats having a back and seat portion, a base, an adjustable element, a user interface device, and a controller. The back portion includes a back heating member that provides heat to a user's torso. The seat portion includes a lower limb heating member that provides heat to the user's lower limbs. The base supports each seat. The adjustable element is coupled to the base and one of the seats and adjusts height of the seat. The user interface device receives an input regarding a desired temperature of the back heating member and the lower limb heating member. The controller receives the input and adjusts an operation of the back heating member and the lower limb heating member to achieve the desired temperature. The user interface device receives a second input to adjust the a height of the seat relative to the floor surface.

A disposable housing including a single-use thermal exchange component can be configured to be mechanically, removably coupled to a receptacle on a cuff positionable around a joint to provide temperature-based therapy to the joint.

A method and apparatus for manipulating a temperature set-point of a human or homeothermic-animal for increasing or decreasing the body temperature above or below the prevailing body temperature for therapeutic purposes. The method includes the steps of warming or cooling sphenoid sinuses externally resulting in manipulation of the temperature of the pituitary gland which in turn results in manipulation of the body-temperature set-point and the body temperature manipulates accordingly to the new temperature set-point. A heat exchange medium can be used to warm or cool sphenoid sinuses and thus the pituitary gland. The heat exchange fluid can be liquid, or gas maintained at a predetermined temperature. Alternatively, a temperature-controlled probe can be used that upon contact with the sphenoid sinuses provides for the heat exchange.

The present invention provides a device for rejuvenating a region of skin or mucosal tissue, comprising: a pulsed electromagnetic frequency generator; a plurality of electrodes in communication with the pulsed electromagnetic frequency generator and an RF tissue diathermy device. The electrodes apply the pulsed electromagnetic power and the RF tissue diathermy to the tissue, heating it such that one portion of the region of mucosal tissue is maintained at a predetermined temperature range T.sub.1 while another portion of the region of mucosal tissue is at least temporarily maintained at predetermined temperature range T.sub.2.