The present invention provides a liquid crystal composition and a liquid crystal display device. The liquid crystal composition comprises at least one compound of general formula I, at least one compound of general formula II and at least one compound of general formula III. The liquid crystal composition provided in the present invention has an appropriate optical anisotropy, an appropriate clearing point, an appropriate absolute value of dielectric anisotropy, a larger K value, a smaller rotational viscosity, a shorter response time, a higher transmittance, a higher contrast rate and a longer low-temperature storage time, and a liquid crystal display device prepared thereby has excellent performances and is suitable for fast-response, high-contrast VA, IPS, NFFS display modes and the like.