Radiation curable phase change solutions (PCM) and said solutions as a thermoset thermal energy gels (a radiation cured polymeric network) has a hydrophobic PCM, a polybutadiene urethane acrylate oligomer soluble in the hydrophobic PCM and present as 7% wt/wt to 25% wt/wt of the gel, a photoinitiator soluble in the hydrophobic PCM and present as 0.01% wt/wt to 0.5% wt/wt of the gel, a mono-functional or di-functional crosslinker soluble in the hydrophobic PCM and present as 0% wt/wt to 10% wt/wt of the gel, and a hydrogenated styrenic block copolymer as a secondary resin as 0% to 20% wt/wt of the gel and optionally a tertiary resin as 0% to 5% wt/wt of the gel, wherein the tertiary resin is a hydrogenated styrenic block copolymer that is different than the secondary resin. The solution or gel is sealed in a container, e.g., a sachet, to form a cold pack.

An oral device includes an intraoral bolus simulator having an exterior surface and an interior volume fillable with a fluid. An extraoral user interface extends from the bolus simulator, and can be used to locate or position the intraoral bolus simulator. In various embodiments, the fluid may be a gas or a liquid, or combinations thereof. In other embodiments, an oral device includes an extraoral handle, a shield connected to the handle, a tether extending from the shield, and a bolus simulator connected to the tether.

Exemplary embodiments of the present disclosure provide method and apparatus for effecting (e.g., lightening) an appearance of skin by cooling or freezing small separated surface regions of the skin to produce regions of local hypopigmentation. The width of the regions can be, for example, smaller than about 1 mm or 0.5 mm, and a distance between these frozen regions can be greater than about 3 times the width of the regions. An exemplary apparatus can be provided that includes a plurality of spatially-separated thermally conductive arrangements that can be affixed or otherwise coupled to a base. For example, the conductive arrangements can be regions of conductive material provided in or proximal to a thermal insulator, or thermally conductive protrusions affixed to the base. The conductive arrangements can be cooled and then contacted with the skin surface to produce the small regions of hypopigmentation.

Dry eye treatment apparatus and methods are described herein which generally comprise a patch or strip affixed to the skin of the upper and/or lower eyelids to deliver heat or other forms of energy, pressure, drugs, moisture, etc. (alone or in combination) to the one or more meibomian glands contained within the underlying skin. The treatment strip or strips include one or more strips configured to adhere to an underlying region of skin in proximity to one or both eyes of a subject such that the one or more strips allow for the subject to blink naturally without restriction from the one or more patches. Moreover, the one or more strips may be configured to emit energy to the underlying region of skin and where the one or more strips are shaped to follow a location of one or more meibomiam glands contained within the underlying region of skin.

There is described an apparatus for heating or cooling a material to be heated or to be cooled. The apparatus includes: a first compartment for containing the material to be heated or to be cooled; and a second compartment containing a phase change material, wherein the phase change material is either for generating heat to heat the first compartment or absorbing heat to cool the first compartment when undergoing a phase change. There are further described various different activating arrangements for activating a change of phase of the phase change material.

This invention provides a flexible and dynamic energy storage and transfer device for safe storage and transport of temperature sensitive products and for therapeutic uses. The portable device includes interactive chambers containing energy receptor materials with thermal holding capacity for cooling and heating purposes. Various chambers may be included to provide varying temperature zones. According to yet another aspect of the invention, a secondary layer is used to respond to environmental temperatures including ambient and exhaustive storage temperatures to extend the energy exchange period and sustain a thermal therapeutic dose toward targeted area.

Method, systems and devices for treating insomnia by non-invasive hypothermic treatment are described. In general, these devices, systems and method enable cooling of the frontal cortex prior to and/or during sleep to enhance sleep, which may be particularly beneficial to treat insomnia.

Methods of making a thermoset thermal energy gels, such as one having a radiation cured polymeric network, are disclosed. The methods include providing a hydrophobic PCM in its liquid state, adding a polybutadiene urethane acrylate oligomer and a mono-functional or di-functional crosslinker soluble in the hydrophobic PCM to the hydrophobic PCM while maintaining the liquid state of the hydrophobic phase change material to form a liquid homogenous mixture, then adding a photoinitiator, which is soluble in the hydrophobic PCM, with mixing to form a final mixture. Next, curing the final mixture occurs by exposure to radiation to form the thermoset thermal energy gel.

The device provides a portable means of lowering human core body temperature by cooling the blood that circulates through glabrous skin. The device is fundamentally comprised of a container and a non-toxic, organic, phase-change material, such as oleic acid, selected because it transitions from a solid to liquid phase between 8 and 20 C., and preferably between 10 to 15 C. This phase-change material acts as a heatsink when placed in contact with glabrous skin thereby allowing the device to absorb heat from the circulating blood. The cooled blood then circulates through the body, lowering core body temperature. The status of the phase-change can be observed, often through transparent container walls, and the device is thermally recharged as needed.

Provided is a spine immobilization device that is able to suppress the sense of discomfort felt when worn to a low level. A spine immobilization device is an immobilization device that immobilizes a person's spine and is provided with a sheet part and a core part. The sheet part has a sheet-like shape and is configured to be stuck to the body surface. The core part is fastened to the back surface of the sheet part. The core part is configured to extend along a spine. In this state, the core part laterally supports the spine.